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  • Losartan Potassium
    9 Drugs classified under this active ingredient


    All the Active Ingredient Drugs

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    Losardex 12.5, 50, 100 mg
    Dexcel
    RX
    partial basket chart
    Losardex 12.5, 50, 100 mg

    Angiotensin II Antagonist. Losartan Potassium 12.5 mg, 50 mg, 100 mg.
    TABS./CAPLET.: 30.
    Hypertens.: Init. & mainten. dose is 50
    mg ×1/ d. for most pts. The max.
    antihypertens. effect is attained 3-6
    wks. after init. of ther. Some pts. may
    receive an addt. benefit by incr.the
    dose to 100 mg ×1/ d. (in the morn.). May be admin. alone or with other
    antihypertens. agents, especial. with
    diuret. (e.g. hydrochlorothiazide).
    Renal protect. in Type-2 diab. pts. with
    proteinuria: Init. is 50 mg ×1/d. The
    dose may be incr. to 100 mg×1/d.
    based on blood press. response from
    one month onwards after initiat. of
    ther. May be admin. with other
    antihypertens. agents (e.g. diuretics,
    CCBs, α or β-block., and central. act.
    agents) as well as with insulin and
    other common. used hypoglycem.
    agents (e.g. sulfonylureas, glitazones
    and glucosidase inhib.).
    HF: usual init. dose of losartan in pts.
    with HF is 12.5 mg×1/d. The dose
    should general. be titrated at wkly.
    interv. (i.e. 12.5 mg dly., 25 mg dly.,50
    mg dly., 100 mg dly., up to a max. dose
    of 150 mg ×1/d ) as tolerated by the pt.
    Reduct. in the risk of cardiovasc.
    morbid., mortal. in hypertens. pts. with
    left ventric. hypertroph.: init. 50 mg of
    ×1/d. A low dose of
    hydrochlorothiazide should be added
    and/or the dose of losartan should be
    incr.to 100 mg ×1/d based on blood
    pres. response.
    Pts. with intravasc. volume depletion:
    (e.g. those treated with high-dose
    diuretics), init. dose of 25 mg×1/d
    should be considered.
    Pts. with renal impair. and
    haemodialysis pts.: No init. dosage
    adjust. is necessary.
    Pts. with hep. impair. : A lower dose
    should be consid.
    Elderly: initiat. ther. with 25 mg in pts.
    over 75 yrs. of age, dosage adjust. is
    not usually necessary for the elder. See
    lit.
    12.5 mg: tmt. of HF, when tmt. with an
    ACE inhib. is no longer consid. approp.
    Switch. pts. with HF who are stable on an
    ACE inhib. to this drug is not recom.
    50, 100 mg: Tmt. of hypertens.,
    HF: Tmt. of HF, usual.in addit. to diuret.
    and/or digitalis, if use of an ACE inhib. is
    not approp. Switch. pts. with HF who are
    stable on an ACE inhib. to this drug is not
    recom.
    Ren. protect. in Type-2 diab. pts. with
    proteinuria: delays the progress.of ren.
    dis. as measured by a reduct. in the
    combin. incidence of doubl. of serum Cr.,
    end stage ren. dis. (need for dialysis/ ren.
    transplant.) or death; and to reduce
    proteinuria. Reduct. in the risk of
    cardiovasc. morbid. & mortal. in
    hypertens. pts. with left ventr.
    hypertroph.
    Reduces the risk of cardiovasc. morbid.
    &mortal. as measured by the combin.
    incidence of cardiovasc. death, stroke,
    and MI in hypertens. pts. with left ventr.
    hypertroph.. The benefit of the drug on
    the prim. deposit endpoint was largely
    driven by reduct. in the risk of stroke.
    C/I: Hypersens. 2nd, 3rd trim. of preg.
    Sev. hep. impair. Concom. use with aliskiren, in pts. with diab.mell. or ren. impair. (GFR < 60 ml/min/1.73 m²). See lit.

    Losardex Plus
    Dexcel
    RX
    partial basket chart
    Multiple ingredients
    Losardex Plus

    Angiotensin II Antagonist, Thiazide Diuretic. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg.
    TABS.: 30. Hypertens. : The usual maint. dose: 1tab.×1/d. For pts. who do not respond adequate. to the drug, the dosage may be incr. to 2 tab.×1/d. The max. dose: 2 tab.×1/d In general, the antihypertens.
    effect is attain. within 3-4 to wks. after
    initiat. of ther. Reduction in the risk of stroke in patients with hypertension and left ventric. hypertrophy. The usual init. dose is 50mg ×1/d. If goal blood pressure is not reached with losartan 50 mg, ther. should be titrat. using a comb. of losartan and a low dose of HCTZ (12.5 mg) and, if
    needed, the dose should then be incr.
    to losartan 100 mg and HCTZ 12.5 mg
    ×1/d. If necessary, the dose should be
    incr. to losartan 100 mg and HCTZ 25
    mg ×1/d.
    Pts. with renal impair. and
    haemodialysis pts.: No init. dosage
    adjust. is necessary in pts. with moder.
    renal impair. (i.e.Cr Cl 30-50 ml/min).
    Losartan/ HCTZ are not recomm.for
    haemodialysis pts. The drug suitable
    alternative formul. in pts. who would
    otherwise be treated concom. with
    losartan 50 mg plus HCTZ 12.5 mg.
    Volume and /or sodium deplet. should
    be corrected prior to admin. of this
    drug.; See lit.
    Tmt. of hypertens., for pts. in whom
    combin. ther. is appropriate.
    Reduct. the risk of stroke in pts. with
    hypertens. and left ventric. hypertrop.
    C/I: Hypersens. to losartan,
    sulphonamide-derived substances (as
    hydrochlorothiazide). Ther. resistant
    hypokalaemia or hypercalcaemia.
    Sev. hep. impair. ; cholestasis & biliary
    obstruct. disord.
    Refractory hyponatraemia
    Symtom. hyperuricaemia/gout;
    2nd, 3rd trimmest.of preg.;
    Sev. renal impair. (i.e. CrCl <30 ml/min)
    Anuria The concom. use with aliskirencontain.
    products in pts. with diabetes
    mellitus/ renal impair. (GFR < 60 ml/
    min/1.73 m²).

    Losarta 50
    CTS
    RX
    partial basket chart
    Losarta 50

    Angiotensin II Antagonist. Losartan Potassium 50 mg.
    TABS: 30. Hypertens: Init. & maint: 50
    mg 1 x dly. Max. effect. aft. 3-6 wks.
    May incr. to 100 mg 1 x dly. Pts. with IV
    vol. deplet: Initial 25 mg 1 x dly. Elderly,
    pts. with ren. impair, incl. pts. on dialys: No initial dose adjust. necess. Hepat.
    impair: Consider lower dose. Heart fail:
    Init: 12.5 mg 1 x dly. Titrate wkly
    intervals to maint. of 50 mg 1 x dly.
    Reduct. risk CV morbid/mortal. in
    hypertens. pts with left ventric.
    hypertrophy: Initial: 50 mg 1 x dly. Add
    low dose HCTZ or incr. dose losartan to
    100 mg 1 x dly based on pt response.
    Type-2 diabet. with proteinuria: Initial:
    50 mg 1 x dly, may increase to 100 mg
    1 x dly depend. on BP. See lit.
    C/I: Hypersens. Pregn, lact: See lit.

    Losarta Plus
    CTS
    RX
    partial basket chart
    Multiple ingredients
    Losarta Plus

    Angiotensin II Antagonist, Thiazide. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg.
    TABS: 30. Admin. with/out food, may
    admin. with other antihypertensives.
    Hypertens: Initial: 1 tab 1 x dly. Max: 2
    tabs 1 x dly. Effect within 3 wks. No
    adjust. elderly pts. Reduct. stroke risk
    in hypertens. pts with left ventric.
    hypertrophy: Initial: 1 tab 1 x dly. If
    goal BP not reached, incr. to 2 tabs 1 x
    dly.
    Tmt. hypertens., for pts. in whom comb.
    ther. is appropr. Reduce risk of stroke in pts.
    with hypertens. and left ventric.
    hypertrophy.
    C/I: Known hypersens., also to
    sulfonamide-derivs, pts with anuria,
    pregn 2nd, 3rd trimests.

    Lotan
    Unipharm
    RX
    partial basket chart
    Lotan

    Angiotensin II Antagonist. Losartan Potassium 12.5 mg, 50 mg, 100 mg.
    TABS: 7 x 12.5 mg, 30 x 50 mg, 100 mg.
    Hypertens: 1 x 50 mg dly; Heart fail:
    1 x 12.5 or 50 mg dly.
    Hypertens., heart fail., reduct. risk CV
    morbidity and mortality in hypertens. pts
    with left ventric. hypertrophy, ren.
    protect. in type 2 diabet. pts. with
    proteinur, diabet. nephropathy.
    C/I: Hypersens., pregn.

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