Losartan Potassium

9 Drugs classified under this active ingredient

Angiotensin II Antagonist. Losartan Potassium 12.5 mg, 50 mg, 100 mg.
TABS./CAPLET.: 30.
Hypertens.: Init. & mainten. dose is 50
mg ×1/ d. for most pts. The max.
antihypertens. effect is attained 3-6
wks. after init. of ther. Some pts. may
receive an addt. benefit by incr.the
dose to 100 mg ×1/ d. (in the morn.). May be admin. alone or with other
antihypertens. agents, especial. with
diuret. (e.g. hydrochlorothiazide).
Renal protect. in Type-2 diab. pts. with
proteinuria: Init. is 50 mg ×1/d. The
dose may be incr. to 100 mg×1/d.
based on blood press. response from
one month onwards after initiat. of
ther. May be admin. with other
antihypertens. agents (e.g. diuretics,
CCBs, α or β-block., and central. act.
agents) as well as with insulin and
other common. used hypoglycem.
agents (e.g. sulfonylureas, glitazones
and glucosidase inhib.).
HF: usual init. dose of losartan in pts.
with HF is 12.5 mg×1/d. The dose
should general. be titrated at wkly.
interv. (i.e. 12.5 mg dly., 25 mg dly.,50
mg dly., 100 mg dly., up to a max. dose
of 150 mg ×1/d ) as tolerated by the pt.
Reduct. in the risk of cardiovasc.
morbid., mortal. in hypertens. pts. with
left ventric. hypertroph.: init. 50 mg of
×1/d. A low dose of
hydrochlorothiazide should be added
and/or the dose of losartan should be
incr.to 100 mg ×1/d based on blood
pres. response.
Pts. with intravasc. volume depletion:
(e.g. those treated with high-dose
diuretics), init. dose of 25 mg×1/d
should be considered.
Pts. with renal impair. and
haemodialysis pts.: No init. dosage
adjust. is necessary.
Pts. with hep. impair. : A lower dose
should be consid.
Elderly: initiat. ther. with 25 mg in pts.
over 75 yrs. of age, dosage adjust. is
not usually necessary for the elder. See
lit.
12.5 mg: tmt. of HF, when tmt. with an
ACE inhib. is no longer consid. approp.
Switch. pts. with HF who are stable on an
ACE inhib. to this drug is not recom.
50, 100 mg: Tmt. of hypertens.,
HF: Tmt. of HF, usual.in addit. to diuret.
and/or digitalis, if use of an ACE inhib. is
not approp. Switch. pts. with HF who are
stable on an ACE inhib. to this drug is not
recom.
Ren. protect. in Type-2 diab. pts. with
proteinuria: delays the progress.of ren.
dis. as measured by a reduct. in the
combin. incidence of doubl. of serum Cr.,
end stage ren. dis. (need for dialysis/ ren.
transplant.) or death; and to reduce
proteinuria. Reduct. in the risk of
cardiovasc. morbid. & mortal. in
hypertens. pts. with left ventr.
hypertroph.
Reduces the risk of cardiovasc. morbid.
&mortal. as measured by the combin.
incidence of cardiovasc. death, stroke,
and MI in hypertens. pts. with left ventr.
hypertroph.. The benefit of the drug on
the prim. deposit endpoint was largely
driven by reduct. in the risk of stroke.
C/I: Hypersens. 2nd, 3rd trim. of preg.
Sev. hep. impair. Concom. use with aliskiren, in pts. with diab.mell. or ren. impair. (GFR < 60 ml/min/1.73 m²). See lit.

Angiotensin II Antagonist, Thiazide Diuretic. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg.
TABS.: 30. Hypertens. : The usual maint. dose: 1tab.×1/d. For pts. who do not respond adequate. to the drug, the dosage may be incr. to 2 tab.×1/d. The max. dose: 2 tab.×1/d In general, the antihypertens.
effect is attain. within 3-4 to wks. after
initiat. of ther. Reduction in the risk of stroke in patients with hypertension and left ventric. hypertrophy. The usual init. dose is 50mg ×1/d. If goal blood pressure is not reached with losartan 50 mg, ther. should be titrat. using a comb. of losartan and a low dose of HCTZ (12.5 mg) and, if
needed, the dose should then be incr.
to losartan 100 mg and HCTZ 12.5 mg
×1/d. If necessary, the dose should be
incr. to losartan 100 mg and HCTZ 25
mg ×1/d.
Pts. with renal impair. and
haemodialysis pts.: No init. dosage
adjust. is necessary in pts. with moder.
renal impair. (i.e.Cr Cl 30-50 ml/min).
Losartan/ HCTZ are not recomm.for
haemodialysis pts. The drug suitable
alternative formul. in pts. who would
otherwise be treated concom. with
losartan 50 mg plus HCTZ 12.5 mg.
Volume and /or sodium deplet. should
be corrected prior to admin. of this
drug.; See lit.
Tmt. of hypertens., for pts. in whom
combin. ther. is appropriate.
Reduct. the risk of stroke in pts. with
hypertens. and left ventric. hypertrop.
C/I: Hypersens. to losartan,
sulphonamide-derived substances (as
hydrochlorothiazide). Ther. resistant
hypokalaemia or hypercalcaemia.
Sev. hep. impair. ; cholestasis & biliary
obstruct. disord.
Refractory hyponatraemia
Symtom. hyperuricaemia/gout;
2nd, 3rd trimmest.of preg.;
Sev. renal impair. (i.e. CrCl <30 ml/min)
Anuria The concom. use with aliskirencontain.
products in pts. with diabetes
mellitus/ renal impair. (GFR < 60 ml/
min/1.73 m²).

Angiotensin II Antagonist. Losartan Potassium 50 mg.
TABS: 30. Hypertens: Init. & maint: 50
mg 1 x dly. Max. effect. aft. 3-6 wks.
May incr. to 100 mg 1 x dly. Pts. with IV
vol. deplet: Initial 25 mg 1 x dly. Elderly,
pts. with ren. impair, incl. pts. on dialys: No initial dose adjust. necess. Hepat.
impair: Consider lower dose. Heart fail:
Init: 12.5 mg 1 x dly. Titrate wkly
intervals to maint. of 50 mg 1 x dly.
Reduct. risk CV morbid/mortal. in
hypertens. pts with left ventric.
hypertrophy: Initial: 50 mg 1 x dly. Add
low dose HCTZ or incr. dose losartan to
100 mg 1 x dly based on pt response.
Type-2 diabet. with proteinuria: Initial:
50 mg 1 x dly, may increase to 100 mg
1 x dly depend. on BP. See lit.
C/I: Hypersens. Pregn, lact: See lit.

Angiotensin II Antagonist, Thiazide. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg.
TABS: 30. Admin. with/out food, may
admin. with other antihypertensives.
Hypertens: Initial: 1 tab 1 x dly. Max: 2
tabs 1 x dly. Effect within 3 wks. No
adjust. elderly pts. Reduct. stroke risk
in hypertens. pts with left ventric.
hypertrophy: Initial: 1 tab 1 x dly. If
goal BP not reached, incr. to 2 tabs 1 x
dly.
Tmt. hypertens., for pts. in whom comb.
ther. is appropr. Reduce risk of stroke in pts.
with hypertens. and left ventric.
hypertrophy.
C/I: Known hypersens., also to
sulfonamide-derivs, pts with anuria,
pregn 2nd, 3rd trimests.

Angiotensin II Antagonist. Losartan Potassium 12.5 mg, 50 mg, 100 mg.
TABS: 7 x 12.5 mg, 30 x 50 mg, 100 mg.
Hypertens: 1 x 50 mg dly; Heart fail:
1 x 12.5 or 50 mg dly.
Hypertens., heart fail., reduct. risk CV
morbidity and mortality in hypertens. pts
with left ventric. hypertrophy, ren.
protect. in type 2 diabet. pts. with
proteinur, diabet. nephropathy.
C/I: Hypersens., pregn.