All the Active Ingredient Drugs
Angiotensin II Antagonist, Diuretics. Candesartan Cilexetil 16 mg, Hydrochlorothiazide 12.5 mg. TABS: 28. 1 tab x dly with or without
food. Elderly: No special dosage. Use
in pts with impair. ren. fusal: see lit.
Not recommend. for child.
Antihypertens. effect usually attained
within 4 wks.
Essent. hypertens. where monother. with
candesartan cilexetil or HCTZ is not
suffic.
C/I: Hypersens., severe ren. impair.,
severe hepat. impair and / or cholestas.,
gout.
Angiotensin II Antagonist, Thiazide. Candesartan Cilexetil 16 mg, Hydrochlorothiazide 12.5 mg. TABS: 30. Adults, elderly: 1 tab. 1 x dly
with/out food. Pts. with intravasc. vol.
deplet: Dose titrat. of candesartan
cilexetil is recommend. (init. 4 mg dose of
candesartan cilexetil may be considered).
Impair. ren. funct: Dose titrat. of
candesartan cilexetil is recommend.
when creatinine clear. ≥ 30 ml/min/1.73
m2 BSA (recommend. dose candesartan
cilexetil 4 mg in pts/ with mild-mod. ren.
impair.). Not to be used in pts with severe
ren. impair. creatinine clear. < 30 ml/
min/1.73 m2 BSA). Impair. hepat. funct:
Dose titrat. is recommend. in mild-mod.
impair. (recommend. start. dose is 2 mg).
Not to be used in pts. with severe hep.
impairm./cholestas. Safety, effic. not
estab. in child.
Essent. hypertens. where monother. with
candesartan cilexetil or
hydrochlorothiazide not. suffic.
C/I: Hypersens. to prod./sulfonamide
derived drugs, pregn., lact., severe ren.
impair., severe hepat. impair./cholestas.,
refractory hypokalem., hypocalcem.,
gout.
Angiotensin II Antagonist, Diuretics. Candesartan Cilexetil 16 mg, Hydrochlorothiazide 12.5 mg. TABS: 28. 1 tab dly. See lit.
Essent. HTN, where monother. with
candesartan cilexetil or HCTZ is not
sufficient.
C/I: Hypersens. to ingredients/
sulfonamide derived drugs, pregn., lact.,
severe ren. impair., severe hepat. impair./
cholestas., hypokalem., hypocalcem.,
gout, tmt. with aliskiren in diabetic pts.
or pts. with impair. renal func.
ACE Inhibitor, Thiazide. Cilazapril 5 mg, Hydrochlorothiazide 12.5 mg. TABS: 28. 1 tab dly.
Essential hypertens. in patients who
have been stabilized on individual
components given in the same
proportions.
C/I: Pregn., lact.
Angiotensin II Antagonist, Thiazide. Valsartan 80 mg, 160 mg, Hydrochlorothiazide 12.5 mg, 25 mg. CO-DIOVAN 80: F.C. TABS: 28. 1 tab dly. Max. effect within 2-4 wks.
Hypertens. when comb. ther. appropriate.
CO-DIOVAN 160: F.C. TABS: 28. 1 tab dly.
Hypertens., when blood pressure not adequat. controlled by monother. To be used as second-line ther.
C/I: Hypersens. Hypersens. to sulfonamide-derived med. products. 2nd & 3rd trim. of preg. Biliary cirrhos. and cholestasis. Pts. with anuria. Refractor. hypokalaemia, hyponatraemia, hypercalcaemia, and symptomat. hyperuricaemia. Concom. use with aliskiren-contain. products in pts. with diab. mell. or renal impair. (GFR <60 mL/min/1.73m²).
Thiazide Diuretic. Hydrochlorothiazide 25 mg. TABS: 30.
High Blood Pressure: The initial dose is
12.5 - 25 mg HCTZ/day. The long-term
dose is usually 12.5 mg HCTZ/day.
Cardiac/hepatic/renal edema: The initial
dose is 25 mg or 50 mg HCTZ/day. The
long-term dose is usually 25 - 100 mg
HCTZ/day.
Patients with impaired cardiac/liver/
kidney function: Dose should be
adjusted. Elderly (above 65 years old):
Attention should be paid to possible
restrictions to kidney function. See lit.
Hypertens., edema.
C/I: Hypersensitivity to HCTZ or to any of
the medicine’s ingredients, other
thiazides, other products which are
based on sulfonamide; severe
disturbances to kidney function (renal
insufficiency with oliguria or anuria);
glomerulonephritis; severe liver
impairment like liver failure with
impaired consciousness (coma and
hepatic precoma); hypokalaemia;
hyponatraemia; hypovolaemia;
hypercalcaemia; high uric acid levels in
the blood which are causing symptoms
(patients with gout in the history); gout;
breastfeeding. See lit.
