All the Drug Class Drugs
Thiazide Diuretic. Hydrochlorothiazide 25 mg. TABS: 30.
High Blood Pressure: The initial dose is
12.5 - 25 mg HCTZ/day. The long-term
dose is usually 12.5 mg HCTZ/day.
Cardiac/hepatic/renal edema: The initial
dose is 25 mg or 50 mg HCTZ/day. The
long-term dose is usually 25 - 100 mg
Patients with impaired cardiac/liver/
kidney function: Dose should be
adjusted. Elderly (above 65 years old):
Attention should be paid to possible
restrictions to kidney function. See lit.
C/I: Hypersensitivity to HCTZ or to any of
the medicine’s ingredients, other
thiazides, other products which are
based on sulfonamide; severe
disturbances to kidney function (renal
insufficiency with oliguria or anuria);
glomerulonephritis; severe liver
impairment like liver failure with
impaired consciousness (coma and
hepatic precoma); hypokalaemia;
hypercalcaemia; high uric acid levels in
the blood which are causing symptoms
(patients with gout in the history); gout;
breastfeeding. See lit.
K+ Sparing Diuretic, Thiazide Diuretic. Amiloride HCl 5 mg, Hydrochlorothiazide 50 mg. TABS: 30. Ed: 1-2 tabs. dly. Hypertens: 1
tab. dly. as single dose or in div. doses.
Not to exceed 2 tabs. dly.
Ed: ed. assoc. with congest. card. fail.
hepat. cirrh. Hypertens: as sole ther.
agent or to enhance effectiveness of
other antihypertens. drugs.
C/I: Anuria, severe progress. renal dis.,
acute renal fail., elevated serum potass.
levels, hypersens. to any of compon.
Angiotensin II Antagonist, Thiazide Diuretic. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg. TABS.: 30. Hypertens. : The usual maint. dose: 1tab.×1/d. For pts. who do not respond adequate. to the drug, the dosage may be incr. to 2 tab.×1/d. The max. dose: 2 tab.×1/d In general, the antihypertens.
effect is attain. within 3-4 to wks. after
initiat. of ther. Reduction in the risk of stroke in patients with hypertension and left ventric. hypertrophy. The usual init. dose is 50mg ×1/d. If goal blood pressure is not reached with losartan 50 mg, ther. should be titrat. using a comb. of losartan and a low dose of HCTZ (12.5 mg) and, if
needed, the dose should then be incr.
to losartan 100 mg and HCTZ 12.5 mg
×1/d. If necessary, the dose should be
incr. to losartan 100 mg and HCTZ 25
Pts. with renal impair. and
haemodialysis pts.: No init. dosage
adjust. is necessary in pts. with moder.
renal impair. (i.e.Cr Cl 30-50 ml/min).
Losartan/ HCTZ are not recomm.for
haemodialysis pts. The drug suitable
alternative formul. in pts. who would
otherwise be treated concom. with
losartan 50 mg plus HCTZ 12.5 mg.
Volume and /or sodium deplet. should
be corrected prior to admin. of this
drug.; See lit.
Tmt. of hypertens., for pts. in whom
combin. ther. is appropriate.
Reduct. the risk of stroke in pts. with
hypertens. and left ventric. hypertrop.
C/I: Hypersens. to losartan,
sulphonamide-derived substances (as
hydrochlorothiazide). Ther. resistant
hypokalaemia or hypercalcaemia.
Sev. hep. impair. ; cholestasis & biliary
2nd, 3rd trimmest.of preg.;
Sev. renal impair. (i.e. CrCl <30 ml/min)
Anuria The concom. use with aliskirencontain.
products in pts. with diabetes
mellitus/ renal impair. (GFR < 60 ml/
Angiotensin II Antagonist, Thiazide Diuretic. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg. TABS: 30. 1 tab dly. Max: 2 tabs dly.
May administer with other
Hypertens. when comb. ther.
C/I: Hypersens. to compon., hypersens.
to sulfonamide derived drugs, anuria,
pregn., severe renal impair., intravasc.
Thiazide Diuretic. Indapamide 2.5 mg. TABS: 30 x 2.5 mg. Hypertens: Initial:
1.25 mg dly in the morn. Aft. 4 wks. if no
response, incr. to 2.5 mg dly. Aft. further
4 wks. may incr. to 5 mg dly. If on
combin. ther., dose of other agent to be
reduced by 50%. Oed: 2.5 mg dly in
morn. Aft. 1 wk. may incr. dose to 5 mg
Hypertens., fluid retent.