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  • Biguanide
    14 Drugs classified under this drug class


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    Competact Tablets
    Abic
    RX
    not in the basket chart
    Multiple ingredients
    Competact Tablets

    Biguanide, Thiazolidinediones. Pioglitazone (as HCl) 15 mg, Metformin Hydrochloride 850 mg.
    F.C. TABS. 56. 1 tab twice dly. Dose titrat. with pioglitazone should be consid. Not
    recommend. for pts. under 18 yrs. old.
    2nd line tmt. of type 2 diab. mell. adult
    pts., particul. overweight pts., who are
    unable to achieve suffic. glyc. control at
    their maxim. tolerated dose of oral
    metformin alone. After initiat. of ther. w/
    pioglitazone, review. pts after 3- 6 mnths
    to assess adeq. response to tmt. (e.g.
    reduct. in HbA1c). In pts. who fail adeq.
    response, pioglitazone should be discount.
    In light of potent. risks w/prolong. ther.,
    confirm at subseq. routine reviews that the
    benefit of pioglitazone is maintained.
    C/I: Hypersens. ,Card. fail., hist. of card. fail.
    (NYHA stages I to IV). Current/ hist blad.
    cancer, Uninvestigated macroscop.
    haematur., Acute or chron. dis. which may
    cause tissue hypox. (E.G. card. or resp. fail.,
    recent MI, shock), hep. impair., acute
    alcohol intox., alcoholism, diab.
    ketoacidosis or diabetic precoma, ren. fail.,
    ren. dysfunc. (CrCl <60 ml/min),Acute
    cond. with the potent. to alter ren. func.
    (such as: dehydr., severe infec., shock,
    intravasc. administ. of iod. contrast ag.),
    lact.

    Eucreas
    Novartis
    RX
    not in the basket chart
    Multiple ingredients
    Eucreas

    Biguanide, DPP-4 Inhibitor. Vildagliptin 50 mg, Metformin Hydrochloride 500, 850, 1000 mg.
    F.C. TABS: 60 x Vildagliptin 50 mg/
    Metformin 500 mg; 60 x
    Vildagliptin 50 mg/Metformin 850 mg;
    Vildagliptin 50 mg/Metformin 1,000 mg.
    Based on the pt. current dose of
    Metformin, tmt. may be init. at either
    50 mg /500 mg or 50 mg/850 mg or 50
    mg/1000 mg tab. strength BID, one
    tab. in the morning and evening. Pts
    already receiving metformin +
    vildagliptin from separate tabs: switch
    to the equivalent combined tab. Daily
    doses >100 mg of vildagliptin are not
    recommend. See lit.
    Tmt. type 2 diabetes mellitus in adult pts.
    insuffic. controlled with max. tolerat.
    dose Metformin alone or already treat.
    with vildaliptin and Metformin as
    separate tabs. In comb. with a
    sulfonylurea as an adjunct to diet and
    exercise in adult pts. inadeq. controlled
    with metformin and a sulfonylurea. In
    triple comb. ther. with insulin as an
    adjunct to diet and exercise to improve
    glycaemic control in adult pts.when
    insulin at a stable dose and Metformin
    alone do not provide adeq. glycaemic
    control.
    C/I: Hypersens., Diab. ketoacid., diabet.
    pre-coma. Ren. fail. ,ren,dysfunc, (CrCl<
    60 ml/min) dehydr., sev. infec., shock.
    Intravasc. admin. of iod. contrast ag. Acute/ chron. dis. which may cause
    tissue hypox., (e.g: Card. fail.). Resp. fail.,
    recent MI, Hep. impair. Acute alcohol
    intox., alcoholism. Lact.

    Glucomin
    Dexcel
    RX
    full basket chart
    Glucomin

    Biguanide. Metformin Hydrochloride 850 mg.
    CAPLETS: 30
    Adult: 1 caplet twice a day, with/aft.
    meals; can adjust gradually up to 3
    caplets daily taken as divided doses.
    Elderly: not indicated when renal
    function is impaired. See lit.
    Diet-failed, non-insulin dependent
    diabetic patients, especially if
    overweight, either alone as initial
    therapy or in combination with a
    sulfonylurea. Occasionally, as adjuvant
    therapy in insulin-dependent diabetic
    patients particularly who are usually
    obese and not well controlled with
    insulin.
    C/I: Hypersens. moder.- sev.renal fail. or
    renal dysfunc., renal dis.which may also
    result from cond. such as cardiovasc.
    collapse (shock), acute dis.
    e.g.dehydration (diarrhea, vomit., fever),
    severe infect. and/or hypoxic states
    (septicemia, urin.infec., pneumopathy),
    hypoxic states: cardiovasc.collapse
    (shock) from whatever cause, acute
    congest. heart fail. acute MI, other cond.
    characterized by hypoxemia (any sev.
    resp. disturb.), hep. fail., since sev. hep. dysfunc. has been assoc. with some
    cases of lactic acidosis. Pts. with clin. or
    lab. evidence of hep. dis. Should be
    tempor. withheld in pts. undergoing rad.
    studies involv. paren. admin. of
    iodinated contrast materials except for
    fluorescein photoretinog. which does
    not necessitate metformin withhold.
    Exces. alcohol intake, acute or chronic.
    Acute or chronic metab. acidosis, includ.
    diabetic ketoacidosis, with or without
    coma. 2 days before elective major
    surgery, and for 2 days follow. surg. or
    any traum. cond. Hist. of lact. acidosis.
    Lacta.Uncontrol. diabetes, with e.g.
    severe hyperglyc., nausea, vom.,
    dehydration, rapid weight loss. Impair.
    func. of the heart or recent heart attack,
    stroke. Blood clot in the lungs. Pancreas
    inflam. Pts. over 80 yrs. old and not yet
    passed kidney funct. assess. See lit..

    Glucophage Caplets
    Abic
    RX
    full basket chart
    Glucophage Caplets

    Biguanide. Metformin Hydrochloride 850 mg.
    CAPLETS: 30. 2 tabs. dly. in 2 div. doses,
    with meals. See lit.
    NIDDM espec. if overweight, alone or in
    comb. with sulfonylurea; occass. in IDDM
    who are obese and no well controlled with
    insulin.

    Januet 50/1,000 mg
    MSD
    RX
    not in the basket chart
    Multiple ingredients
    Januet 50/1,000 mg

    Biguanide, DDP-4 Inhibitor. Metformin Hydrochloride 1,000 mg, Sitagliptin 50 mg.
    TABS: 56. 2 x dly with meals. Graduate
    dosage to avoid GI side effects. Max.
    dly dose: 100 mg sitagliptin/2,000 mg
    metformin HCl.
    Adjunct to diet/excercise to improve
    glycemic control in type 2 diabetes
    mellitus, when tmt. with both sitagliptin
    and metformin approp. Not to be used in
    type 1 diabetes or tmt. diabet.
    ketoacidos. Not studied in history
    pancreatit. See lit.
    C/I: Ren. dis./dysfunct.; acute/chron.
    metabol. acidos. (incl. diabet. acidos.)
    with/out coma, hypersens., discont.
    when undergoing radiolog. studies
    involving IV admin. or iodinated contrast
    materials.

    Januet 50/500 mg
    MSD
    RX
    not in the basket chart
    Multiple ingredients
    Januet 50/500 mg

    Biguanide, DPP-4 Inhibitor. Metformin Hydrochloride 500 mg, Sitagliptin 50 mg.
    TABS: 56. 2 x dly with meals. Graduate
    dosage to avoid GI side effects. Max.
    dly dose: 100 mg sitagliptin/2,000 mg
    metformin HCl.
    Adjunct to diet/excercise to improve
    glycemic control in type 2 diabetes
    mellitus, when tmt. with both sitagliptin
    and metformin approp. Not to be used in
    type 1 diabetes or tmt. diabet.
    ketoacidos. Not studied in history
    pancreatit. See lit.
    C/I: Ren. dis./dysfunct.; acute/chron.
    metabol. acidos. (incl. diabet. acidos.)
    with/out coma, hypersens., discont.
    when undergoing radiolog. studies
    involving IV admin. or iodinated contrast
    materials.

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