All the Active Ingredient Drugs
Biguanide, DPP-4 Inhibitor. Vildagliptin 50 mg, Metformin Hydrochloride 500, 850, 1000 mg. F.C. TABS: 60 x Vildagliptin 50 mg/
Metformin 500 mg; 60 x
Vildagliptin 50 mg/Metformin 850 mg;
Vildagliptin 50 mg/Metformin 1,000 mg.
Based on the pt. current dose of
Metformin, tmt. may be init. at either
50 mg /500 mg or 50 mg/850 mg or 50
mg/1000 mg tab. strength BID, one
tab. in the morning and evening. Pts
already receiving metformin +
vildagliptin from separate tabs: switch
to the equivalent combined tab. Daily
doses >100 mg of vildagliptin are not
recommend. See lit.
Tmt. type 2 diabetes mellitus in adult pts.
insuffic. controlled with max. tolerat.
dose Metformin alone or already treat.
with vildaliptin and Metformin as
separate tabs. In comb. with a
sulfonylurea as an adjunct to diet and
exercise in adult pts. inadeq. controlled
with metformin and a sulfonylurea. In
triple comb. ther. with insulin as an
adjunct to diet and exercise to improve
glycaemic control in adult pts.when
insulin at a stable dose and Metformin
alone do not provide adeq. glycaemic
control.
C/I: Hypersens., Diab. ketoacid., diabet.
pre-coma. Ren. fail. ,ren,dysfunc, (CrCl<
60 ml/min) dehydr., sev. infec., shock.
Intravasc. admin. of iod. contrast ag. Acute/ chron. dis. which may cause
tissue hypox., (e.g: Card. fail.). Resp. fail.,
recent MI, Hep. impair. Acute alcohol
intox., alcoholism. Lact.
DPP-4 Inhibitor. Vildagliptin 50 mg. TABS: 7, 14, 28, 56.
Dosage must be indivi. ajust. for each pt.
Monotherpy: 50 mg x1 dly in the
morning or 50 mg x 2 dly (morn.,even.).
In combin. with other antidiabetics:
see lit. Max 100 mg dly, with/out food.
As adjunct to diet, exercise in type 2
diabetes mellitus: As monother. if diet,
exercise insuffic., or in combinat. with
metformin or sulfonylurea if tmt. with
these offers insuffic. control blood
glucose. As triple ther. in combinat. with
a sulphonylurea and metformin when
diet, exercise plus dual therapy do not
provide adequate glycaemic control.
Comb. use with insulin (with/ without
metformin) when diet, exercise plus a
stable dose of insulin do not provide
adequate glycaemic control. As an
adjunct to diet and exercise in pts. with
type 2 diabetes mellitus.In comb. with a
thiazolidinedione, in pts. with insuffic.
glycaemic control and for whom the use
of a thiazolidinedione is appropriate.
C/I: Hypesens.
