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  • Thiazolidinediones
    2 Drugs classified under this drug class


    All the Drug Class Drugs

    Actos
    Abic
    RX
    partial basket chart
    Actos

    Thiazolidinediones. Pioglitazone 15, 30, 45 mg.
    TABS.: 15 mg, 30 mg, 45
    mg x 28.
    Once dly with or w/o food. Initial treat.:
    15 mg or 30 mg once dly; may be
    increased up to 45 mg once dly. May
    be used in combination with insulin.
    See lit. Elderly: No dose adjustment is
    necessary. Renal impair.ent: No dose
    adjustment is necessary in pts. with
    impaired renal func. (CLcr > 4 ml/min) Not to be used in dialysed pts. Hepatic
    impair.ent: should not be used in pts.
    With hepatic impair.ent Paediatric: Not
    to be used in children and adolescents
    under 18 yrs of age.
    As second or third line treatment of type 2
    diabetes mellitus: as monotherapy: in
    adult patients (particularly overweight
    patients) inadequately controlled by diet
    and exercise for whom metformin is
    inappropriate because of
    contraindications or intolerance as dual
    oral therapy in combination with
    metformin, in adult patients (particularly
    overweight patients) with insufficient
    glycaemic control despite maximal
    tolerated dose of monotherapy with
    metformin; with a sulphonylurea, only in
    adult patients who show intolerance to
    metformin or for whom metformin is
    contraindicated, with insufficient
    glycaemic control despite maximal
    tolerated dose of monotherapy with a
    sulphonylurea. As triple oral therapy in
    combination with: metformin and a
    sulphonylurea, in adult patients
    (particularly overweight patients) with
    insufficient glycaemic control despite dual
    oral therapy.Pioglitazone is also indicated
    for combination with insulin in type 2
    diabetes mellitus adult patients with
    insufficient glycaemic control on insulin
    for whom metformin is inappropriate
    because of contraindications or
    intolerance.After initiation of therapy with
    pioglitazone, patients should be reviewed
    after 3 to 6 months to assess adequacy of
    response to treatment (e.g. reduction in
    HbA1c). In patients who fail to show an
    adequate response, pioglitazone should
    be discontinued. In light of potential risks
    with prolonged therapy, prescribers should
    confirm at subsequent routine reviews
    that the benefit of pioglitazone is
    maintained.
    C/I: Hypersens. to product; cardiac
    failure or history of cardiac failure (NYHA
    stages I to IV); hepatic impair.ent;
    diabetic ketoacidosis; current bladder
    cancer or a history of bladder cancer;
    uninvestigated macroscopic haematuria.

    Competact Tablets
    Abic
    RX
    not in the basket chart
    Multiple ingredients
    Competact Tablets

    Biguanide, Thiazolidinediones. Pioglitazone (as HCl) 15 mg, Metformin Hydrochloride 850 mg.
    F.C. TABS.: 56. Adult. with normal renal funct. (GFR ≥ 90 mL/min): The recomm. dose of Competact is 30 mg/day pioglitazone plus 1,700 mg/day of metformin HCl (this dose is achievable with 1 tab. of 15 mg/850 mg, taken ×2/d.
    Dose titration with pioglitazone (added to the optimal dose of metformin) should be consid. before the pt. is switched to this medication. See lit.
    Second line tmt. of type 2 diabet. mell. adult pts., particularly overweight pts., who are unable to achieve suffic. glycaem. control at their maxim. tolerated dose of oral metformin alone.
    After initiat. of the. with pioglitazone, pts. should be reviewed after 3-6 mnths. to assess adequacy of response to tmt. (e.g. reduct. in HbA1c). In pts. who fail to show an adequate response, pioglitazone should be discont. In light of potent. risks with prolong. ther., prescribers should confirm at subseq. routine reviews that the benefit of pioglitazone is maintain.
    C/I: Hypersens. Cardiac fail./ history of card. fail. (NYHA stages I- IV). Current bladder cancer or a hist. of bladder cancer. Uninvestigated macroscop. haematuria. Acute/chron. dis. which may cause tissue hypoxia such as cardiac or respirat. fail., recent MF, shock. Hepat. impair. Acute alcohol intoxicat., alcoholism. Any type of acute metabol. acidos. (e.g. lactic acidosis, diabet. ketoacidosis). Diabet. pre-coma. Severe renal fail. (GFR < 30 mL/min). Acute conditions: Dehydrat., Sev. infec., Shock, Intravasc. administ. of iodinated contrast agents., Breast-feed.

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