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  • Thiazolidinediones
    2 Drugs classified under this drug class


    All the Drug Class Drugs

    Actos
    Abic
    RX
    partial basket chart
    Actos

    Thiazolidinediones. Pioglitazone 15, 30, 45 mg.
    TABS.: 15 mg, 30 mg, 45
    mg x 28.
    Once dly with or w/o food. Initial treat.:
    15 mg or 30 mg once dly; may be
    increased up to 45 mg once dly. May
    be used in combination with insulin.
    See lit. Elderly: No dose adjustment is
    necessary. Renal impair.ent: No dose
    adjustment is necessary in pts. with
    impaired renal func. (CLcr > 4 ml/min) Not to be used in dialysed pts. Hepatic
    impair.ent: should not be used in pts.
    With hepatic impair.ent Paediatric: Not
    to be used in children and adolescents
    under 18 yrs of age.
    As second or third line treatment of type 2
    diabetes mellitus: as monotherapy: in
    adult patients (particularly overweight
    patients) inadequately controlled by diet
    and exercise for whom metformin is
    inappropriate because of
    contraindications or intolerance as dual
    oral therapy in combination with
    metformin, in adult patients (particularly
    overweight patients) with insufficient
    glycaemic control despite maximal
    tolerated dose of monotherapy with
    metformin; with a sulphonylurea, only in
    adult patients who show intolerance to
    metformin or for whom metformin is
    contraindicated, with insufficient
    glycaemic control despite maximal
    tolerated dose of monotherapy with a
    sulphonylurea. As triple oral therapy in
    combination with: metformin and a
    sulphonylurea, in adult patients
    (particularly overweight patients) with
    insufficient glycaemic control despite dual
    oral therapy.Pioglitazone is also indicated
    for combination with insulin in type 2
    diabetes mellitus adult patients with
    insufficient glycaemic control on insulin
    for whom metformin is inappropriate
    because of contraindications or
    intolerance.After initiation of therapy with
    pioglitazone, patients should be reviewed
    after 3 to 6 months to assess adequacy of
    response to treatment (e.g. reduction in
    HbA1c). In patients who fail to show an
    adequate response, pioglitazone should
    be discontinued. In light of potential risks
    with prolonged therapy, prescribers should
    confirm at subsequent routine reviews
    that the benefit of pioglitazone is
    maintained.
    C/I: Hypersens. to product; cardiac
    failure or history of cardiac failure (NYHA
    stages I to IV); hepatic impair.ent;
    diabetic ketoacidosis; current bladder
    cancer or a history of bladder cancer;
    uninvestigated macroscopic haematuria.

    Competact Tablets
    Abic
    RX
    not in the basket chart
    Multiple ingredients
    Competact Tablets

    Biguanide, Thiazolidinediones. Pioglitazone (as HCl) 15 mg, Metformin Hydrochloride 850 mg.
    F.C. TABS. 56. 1 tab twice dly. Dose titrat. with pioglitazone should be consid. Not
    recommend. for pts. under 18 yrs. old.
    2nd line tmt. of type 2 diab. mell. adult
    pts., particul. overweight pts., who are
    unable to achieve suffic. glyc. control at
    their maxim. tolerated dose of oral
    metformin alone. After initiat. of ther. w/
    pioglitazone, review. pts after 3- 6 mnths
    to assess adeq. response to tmt. (e.g.
    reduct. in HbA1c). In pts. who fail adeq.
    response, pioglitazone should be discount.
    In light of potent. risks w/prolong. ther.,
    confirm at subseq. routine reviews that the
    benefit of pioglitazone is maintained.
    C/I: Hypersens. ,Card. fail., hist. of card. fail.
    (NYHA stages I to IV). Current/ hist blad.
    cancer, Uninvestigated macroscop.
    haematur., Acute or chron. dis. which may
    cause tissue hypox. (E.G. card. or resp. fail.,
    recent MI, shock), hep. impair., acute
    alcohol intox., alcoholism, diab.
    ketoacidosis or diabetic precoma, ren. fail.,
    ren. dysfunc. (CrCl <60 ml/min),Acute
    cond. with the potent. to alter ren. func.
    (such as: dehydr., severe infec., shock,
    intravasc. administ. of iod. contrast ag.),
    lact.

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