All the Therapeutic System Drugs
Adsorbant, Antiflatulent. Charcoal 140 mg, Simethicone 45 mg. CAPS: 48 (24 blue; 24 pink). 1 blue cap
(gastro-sol.) and 1 pink (gastro-resist.) X
3 dly. Bef. Meals.
Anti-flatulent, for symptomatic
treatment of stomach ache resulting
from accumulation of gas, relief of
sensation of fullness, meteorism,
bloating and flatulence.
C/I: Known hypersens.
PPI. Pantoprazole 20 mg. E.C. TABS: 30. Adult. & adolesc. 12 yrs. of
age and above: Reflux dis. and assoc.
symp. (e.g. heartburn, acid
regurgitation, pain on swallowi.)-
20mg×1/d. Symp. relief is gener.
accompl. within 2-4 wks. If this is not
suffic., symp. relief will normal. be
achieved within a further 4 wks. When
symp. relief has been achieved,
reoccurring symp. can be control. using
an on-demand regimen of 20mg×1/d,
taking one tab. when requir.
Long-term manag.& preven. of relapse
in reflux esophag.: Mainten. dose- is 20
mg×1/d is recomm., incr. to 40 mg ×1/d
if a relapse occurs.After heal. of the
relapse the dose can be reduced again
to 20 mg.
Adults: Preven. of gastroduod. ulc.
induced by NSAIDs in pts. at risk with a
need for contin. NSAID tmt.:
Tmt. of reflux esophagitis & assoc. symp.
(e.g. heartburn, acid regurgitation, pain
on swallow.). For long-term manag. &
prevent. of relapse in reflux esophagitis.
Preven. of gastroduodenal ulc. induced
by NSAIDs in pts. at risk with a need for
continuous NSAIDs tmt.
C/I: Hypersens., subst. benzimidazoles. Comb. ther. for the eradication of H. pylori in pts. with renal impair. or severe hep. impair.
PPI. Pantoprazole 40 mg. E.C. TABS: 14, 28. Tmt. mod-severe
GERD: Adults/adolesc. 12 yrs and
above: 1 tab x dly. Erad. H. pylori in
comb. with 2 approp. antibiotics:
Adults: Depend. On resist. pattern: a) 2
x dly: 1 x 40 mg +1,000 mg amoxillin +
500 mg clarithromycin; b) 2 x dly: 1 x
40 mg + 500 mg metronidazole + 500
mg clarithromycin; c) 2 x dly: 1 x 40 mg
+ 1,000 mg amoxicillin + 500 mg
metronidazole. If comb. ther. not an
option: Monother. as follows: Tmt.
gastric/duod. ulc: 1 tab dly.
Zollinger-Ellison syndr. + other
hypersecret. conds: Long-term
manage: Initial: 80 mg dly. Can titrate
up/ down as reqd. Doses above 80 mg
dly to be div. into 2 doses.
Pts. with hep. impair.: dly. dose of 20
mg exceed. in pts. with sev. hep.
impair, must not be used in comb. tmt.
For eradic. H. pylori in pts. with moder.
– sev. hep. dysfunc. since curren. no
data are availab. on the effic. & safety
of Pantoprazole in comb. tmt. of these
Short term tmt. of acute duod. ulcer,
acute gastric ulcer, mod./sev. reflux
esophagi., eradic. of H. pylori in comb.
With clarithromycin and amoxycillin
orclarithromycin and metronidazole or
amoxicillin and metronidazole in cases of
duoden. ulcer & gastric ulcer with the
object. of reduc. of duod./gastr.ulc.
caused by this microorganism, Zollinger
C/I: Hypersens., subst. benzimidazoles .
Comb. ther. for the eradication of H.
pylori in pts. with renal impair. or severe
PPI. Pantoprazole (as sodium) 40 mg/vial. VIAL: 1. I.V. only (if oral not
appropriate), over 2-15 mins. Duod.
ulc., gastric ulc., mod/severe GERD: 1
vial (40 mg) dly.
Long-term Zollinger-Ellison Syndr. and
other path. hypersecret. conds: Initial:
80 mg dly. Can be titrat. as reqd. Doses
above 80 mg: 1 vial 2 x dly. Above 160
mg not to be given longer than reqd.
for adequate acid control. Rapid acid
control: Initial: 2 x 80 mg within 1 hr.
Trans. to oral form as soon as clin.