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    13 Drugs classified under this drug class

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    Controloc 20
    not in the basket chart
    Controloc 20

    PPI. Pantoprazole 20 mg.
    E.C. TABS: 30. Adult. & adolesc. 12 yrs. of
    age and above: Reflux dis. and assoc.
    symp. (e.g. heartburn, acid
    regurgitation, pain on swallowi.)-
    20mg×1/d. Symp. relief is gener.
    accompl. within 2-4 wks. If this is not
    suffic., symp. relief will normal. be
    achieved within a further 4 wks. When
    symp. relief has been achieved,
    reoccurring symp. can be control. using
    an on-demand regimen of 20mg×1/d,
    taking one tab. when requir.
    Long-term manag.& preven. of relapse
    in reflux esophag.: Mainten. dose- is 20
    mg×1/d is recomm., incr. to 40 mg ×1/d
    if a relapse occurs.After heal. of the
    relapse the dose can be reduced again
    to 20 mg.
    Adults: Preven. of gastroduod. ulc.
    induced by NSAIDs in pts. at risk with a
    need for contin. NSAID tmt.:
    Tmt. of reflux esophagitis & assoc. symp.
    (e.g. heartburn, acid regurgitation, pain
    on swallow.). For long-term manag. &
    prevent. of relapse in reflux esophagitis.
    Preven. of gastroduodenal ulc. induced
    by NSAIDs in pts. at risk with a need for
    continuous NSAIDs tmt.
    C/I: Hypersens., subst. benzimidazoles. Comb. ther. for the eradication of H. pylori in pts. with renal impair. or severe hep. impair.

    Controloc 40
    not in the basket chart
    Controloc 40

    PPI. Pantoprazole 40 mg.
    E.C. TABS: 14, 28. Tmt. mod-severe
    GERD: Adults/adolesc. 12 yrs and
    above: 1 tab x dly. Erad. H. pylori in
    comb. with 2 approp. antibiotics:
    Adults: Depend. On resist. pattern: a) 2
    x dly: 1 x 40 mg +1,000 mg amoxillin +
    500 mg clarithromycin; b) 2 x dly: 1 x
    40 mg + 500 mg metronidazole + 500
    mg clarithromycin; c) 2 x dly: 1 x 40 mg
    + 1,000 mg amoxicillin + 500 mg
    metronidazole. If comb. ther. not an
    option: Monother. as follows: Tmt.
    gastric/duod. ulc: 1 tab dly.
    Zollinger-Ellison syndr. + other
    hypersecret. conds: Long-term
    manage: Initial: 80 mg dly. Can titrate
    up/ down as reqd. Doses above 80 mg
    dly to be div. into 2 doses.
    Pts. with hep. impair.: dly. dose of 20
    mg exceed. in pts. with sev. hep.
    impair, must not be used in comb. tmt.
    For eradic. H. pylori in pts. with moder.
    – sev. hep. dysfunc. since curren. no
    data are availab. on the effic. & safety
    of Pantoprazole in comb. tmt. of these
    Short term tmt. of acute duod. ulcer,
    acute gastric ulcer, mod./sev. reflux
    esophagi., eradic. of H. pylori in comb.
    With clarithromycin and amoxycillin
    orclarithromycin and metronidazole or
    amoxicillin and metronidazole in cases of
    duoden. ulcer & gastric ulcer with the
    object. of reduc. of duod./gastr.ulc.
    caused by this microorganism, Zollinger
    Ellison Syndr.
    C/I: Hypersens., subst. benzimidazoles .
    Comb. ther. for the eradication of H.
    pylori in pts. with renal impair. or severe
    hep. impair..

    Controloc I.V.
    not in the basket chart
    Controloc I.V.

    PPI. Pantoprazole (as sodium) 40 mg/vial.
    VIAL: 1. Duodenal ulcer, gastric ulc., moderate and severe reflux oesophagitis: 40 mg (1 vial) ×1/d.
    Zollinger-Ellison-Syndr.: For the long-term manag. of Zollinger-Ellison-Syndr. pts. should start their tmt. with a dly. dose of 80 mg. Thereafter, the dose can be titrated up or down as needed using measurements of gastric acid secret. to guide. With doses above 80 mg dly., the dose should be divided and given twice dly. A temporary incr. of the dose above 160 mg  is possible but should not be applied longer than requir. for adequate. acid control.
    In case a rapid acid control is requir, a start. dose of 80 mg×2/d. is suffic. to manage a decrease of acid output into the target range (<10 mEq/h) within 1h in the majority of pts.
    Duodenal ulcer. Gastric ulcer. Moderate and severe reflux oesophagitis. Zollinger-Ellison-Syndrome.
    C/I: Hypersens. to the active subst., substitut. benzimidazoles and any of the excipients.

    not in the basket chart

    PPI. Dexlansoprazole 30 mg, 60 mg.
    CAPS.: 28. Tmt. of erosive reflux oesophagitis: One 60 mg cap. once dly. for up to 8 wks. Maint. of healed erosive reflux oesophagitis and maint. of relief of heartburn: One 30 mg cap. once dly. Sympt. non-erosive gastro-esoph. reflux disease (GERD): One 30 mg cap. once dly. for 4 wks. Control. studies did not extend beyond 6 mnths. in adults and 16 wks. in pts. 12-17 yrs. old.
    30mg: adult.& adolesc. aged 12 -17 yrs. for the follow.: Maint. of healed erosive reflux oesophagitis, maint. of relief of heartburn. Short-term tmt. of heartburn & acid regurgitate. assoc. with sympt. nonerosive gastro-esophageal reflux disease GERD. 60mg: adult.& adolesc. aged 12 -17 yrs: Tmt. of erosive reflux oesophagitis.
    C/I: Hypersens. Acute interstit. Nephrit. (AIN) has been reported with other PPIs, includ. lansoprazole of which dexlansoprazole is the R-enantiomer. Concom. use with rilpivirine-contain. products.

    partial basket chart

    PPI. Lansoprazole 15 mg, 30 mg.
    CAPS: 28. Duod. ulc: 30 mg 1 x dly for 4
    wks. Maint: To prevent relapse: 15 mg 1 x
    dly. Benign gastric. ulc: 30 mg 1 x dly for 8
    wks. GERD: 30 mg 1 x dly for 4 wks. If
    needed, 4 wks more. Maint: 15-30 mg.
    GERD: 30 mg (or 15 mg in some
    individuals) 1 x dly for 4 wks. If not
    alleviated, further investigations
    recommended. Maint: 15 mg 1 x dly. Erad.
    H. pylori: 30 mg 2 x dly with antibiotics as
    in med. lit. Zollinger Ellison synd./other
    hypersecretory cond: 2 x 30 mg 1 x dly.
    Adjust per individual as long as necess. Up
    to 180 mg dly have been used. If the req.
    dly dose is greater than 120 mg, div. into 2
    dly doses. NSAID-assoc. benign gastric
    ulc., duod. ulc., relief sympts. in cont.
    NSAID tmt: 15-30 mg 1 x dly for 4 wks. If
    necess. 4 wks more. Pts at risk or with
    refract. ulc., longer tmt. and/or poss.
    higher dose. Elderly: No adjust. reqd.
    Pediatric: No experience.
    Duod. ulc., benign gastric ulc., GERD,
    erad. H. pylori; Zollinger Ellison synd/
    other hypersecretory conds, NSAIDassoc.
    benign gastric ulc., duod. ulc.,
    relief sympts. in cont. NSAID tmt.
    C/I: Pregn..

    Losec 20 mg
    partial basket chart
    Losec 20 mg

    PPI. Omeprazole 20 mg.
    CAPS: 14, 30. Adults over 18 yrs: 1 cap 1 x
    dly bef. meal, in morn. for 14 days. May
    repeat 14 days course every 4 mths.
    Not to exceed recommended dly dose.
    Swallow. difficulties: Open capsule,
    add to orange juice or yogurt within
    30 mins. Capsule can also be sucked
    and contents swallowed.
    Acute duod. ulc., acute gastric ulc., H.
    pylori-assoc. peptic ulc. dis. in combinat.
    with antibiotics, tmt., long-term.
    manage. reflux esophagit., maint. tmt.
    for prevent. relapse severe reflux
    esophagit., tmt. severe reflux esophagit.
    in child > one year of age. Maint. tmt.
    prevent. relapse in pts. with poorly
    respons. peptic ulc. Zollinger Ellison syndrome, tmt./prevent. NSAID-assoc.
    duod./gastric ulc./erosions in high risk
    C/I: Known hypersens; child, adolesc.
    under 18 yrs. Pts. suffer. pain while
    swallow. food, vomit. with blood,
    bloody/black stools, combinat. with