All the Drug Class Drugs
PPI. Pantoprazole 20 mg. E.C. TABS: 30. Adult. & adolesc. 12 yrs. of
age and above: Reflux dis. and assoc.
symp. (e.g. heartburn, acid
regurgitation, pain on swallowi.)-
20mg×1/d. Symp. relief is gener.
accompl. within 2-4 wks. If this is not
suffic., symp. relief will normal. be
achieved within a further 4 wks. When
symp. relief has been achieved,
reoccurring symp. can be control. using
an on-demand regimen of 20mg×1/d,
taking one tab. when requir.
Long-term manag.& preven. of relapse
in reflux esophag.: Mainten. dose- is 20
mg×1/d is recomm., incr. to 40 mg ×1/d
if a relapse occurs.After heal. of the
relapse the dose can be reduced again
to 20 mg.
Adults: Preven. of gastroduod. ulc.
induced by NSAIDs in pts. at risk with a
need for contin. NSAID tmt.:
Tmt. of reflux esophagitis & assoc. symp.
(e.g. heartburn, acid regurgitation, pain
on swallow.). For long-term manag. &
prevent. of relapse in reflux esophagitis.
Preven. of gastroduodenal ulc. induced
by NSAIDs in pts. at risk with a need for
continuous NSAIDs tmt.
C/I: Hypersens., subst. benzimidazoles. Comb. ther. for the eradication of H.
pylori in pts. with renal impair. or severe
PPI. Pantoprazole 40 mg. E.C. TABS: 14, 28. Tmt. mod-severe
GERD: Adults/adolesc. 12 yrs and
above: 1 tab x dly. Erad. H. pylori in
comb. with 2 approp. antibiotics:
Adults: Depend. On resist. pattern: a) 2
x dly: 1 x 40 mg +1,000 mg amoxillin +
500 mg clarithromycin; b) 2 x dly: 1 x
40 mg + 500 mg metronidazole + 500
mg clarithromycin; c) 2 x dly: 1 x 40 mg
+ 1,000 mg amoxicillin + 500 mg
metronidazole. If comb. ther. not an
option: Monother. as follows: Tmt.
gastric/duod. ulc: 1 tab dly.
Zollinger-Ellison syndr. + other
hypersecret. conds: Long-term
manage: Initial: 80 mg dly. Can titrate
up/ down as reqd. Doses above 80 mg
dly to be div. into 2 doses.
Pts. with hep. impair.: dly. dose of 20
mg exceed. in pts. with sev. hep.
impair, must not be used in comb. tmt.
For eradic. H. pylori in pts. with moder.
– sev. hep. dysfunc. since curren. no
data are availab. on the effic. & safety
of Pantoprazole in comb. tmt. of these
Short term tmt. of acute duod. ulcer,
acute gastric ulcer, mod./sev. reflux
esophagi., eradic. of H. pylori in comb.
With clarithromycin and amoxycillin
orclarithromycin and metronidazole or
amoxicillin and metronidazole in cases of
duoden. ulcer & gastric ulcer with the
object. of reduc. of duod./gastr.ulc.
caused by this microorganism, Zollinger
C/I: Hypersens., subst. benzimidazoles .
Comb. ther. for the eradication of H.
pylori in pts. with renal impair. or severe
PPI. Pantoprazole (as sodium) 40 mg/vial. VIAL: 1. I.V. only (if oral not
appropriate), over 2-15 mins. Duod.
ulc., gastric ulc., mod/severe GERD: 1
vial (40 mg) dly.
Long-term Zollinger-Ellison Syndr. and
other path. hypersecret. conds: Initial:
80 mg dly. Can be titrat. as reqd. Doses
above 80 mg: 1 vial 2 x dly. Above 160
mg not to be given longer than reqd.
for adequate acid control. Rapid acid
control: Initial: 2 x 80 mg within 1 hr.
Trans. to oral form as soon as clin.
PPI. Dexlansoprazole 30 mg, 60 mg. CAPS.: 28. Tmt. of erosive reflux oesophagitis: One 60 mg cap. once dly. for up to 8 wks. Maint. of healed erosive reflux oesophagitis and maint. of relief of heartburn: One 30 mg cap. once dly. Sympt. non-erosive gastro-esoph. reflux disease (GERD): One 30 mg cap. once dly. for 4 wks. Control. studies did not extend beyond 6 mnths. in adults and 16 wks. in pts. 12-17 yrs. old.
30mg: adult.& adolesc. aged 12 -17 yrs. for the follow.: Maint. of healed erosive reflux oesophagitis, maint. of relief of heartburn. Short-term tmt. of heartburn & acid regurgitate. assoc. with sympt. nonerosive gastro-esophageal reflux disease GERD. 60mg: adult.& adolesc. aged 12 -17 yrs: Tmt. of erosive reflux oesophagitis.
C/I: Hypersens. Acute interstit. Nephrit. (AIN) has been reported with other PPIs, includ. lansoprazole of which dexlansoprazole is the R-enantiomer. Concom. use with rilpivirine-contain. products.
PPI. Lansoprazole 15 mg, 30 mg. CAPS: 30 x 15 mg, 30 mg. Duod. ulc: 30
mg 1 x dly for 4 wks. Prevent. relapse:
15 mg 1 x dly. Benign gastric ulc: 30 mg
1 x dly for 8 wks. GERD: 30 mg 1 x dly for
4 wks. If not fully healed, cont. for 4 wks
at same dose. Long-term main: 15/30
mg 1 x dly. All in morn. bef. food. Erad.
H. pylori: 30 mg 2 x dly (morn. and
even.) plus 2 of follow. antibiots:
clarithromycin 250 mg 2 x dly,
amoxicillin 1 g 2 x dly, or metrinodazole
400 mg 2 x dly for 7 days. Tmt., proph.
NSAID-assoc. benign gastric ulc., duod.
ulc., relief sympts in pts req. cont. NSAID
tmt: 15/30 mg 1 x dly.
Tmt. duod. ulc., benign gastric. ulc., GERD,
acid related disords upper GI tract. Heal.,
long term tmt. and maint. ther. for pts.
with GERD or duod. ulc. Prev. relapse in pts
with GERD or duod. ulc. Erad. H. Pylori
from upper GI tracts in pts with duod. ulc.,
gastrit., benign ulc. (in comb. with approp.
antibiotics). Short term tmt. (up to 4 wks)
heartburn and/or upper epigast. pain
assoc. with acid-related dyspeps. Longterm
manag. path. hypersecret. conds,
incl. Zollinger Ellison syndr. Tmt., proph. of
NSAID assoc. benign gastric ulc., duod.
ulc., relief sympts. in pts. req. cont. NSAID
C/I: Hypersens., pregn.
PPI. Lansoprazole 15 mg, 30 mg. CAPS: 28. Duod. ulc: 30 mg 1 x dly for 4
wks. Maint: To prevent relapse: 15 mg 1 x
dly. Benign gastric. ulc: 30 mg 1 x dly for 8
wks. GERD: 30 mg 1 x dly for 4 wks. If
needed, 4 wks more. Maint: 15-30 mg.
GERD: 30 mg (or 15 mg in some
individuals) 1 x dly for 4 wks. If not
alleviated, further investigations
recommended. Maint: 15 mg 1 x dly. Erad.
H. pylori: 30 mg 2 x dly with antibiotics as
in med. lit. Zollinger Ellison synd./other
hypersecretory cond: 2 x 30 mg 1 x dly.
Adjust per individual as long as necess. Up
to 180 mg dly have been used. If the req.
dly dose is greater than 120 mg, div. into 2
dly doses. NSAID-assoc. benign gastric
ulc., duod. ulc., relief sympts. in cont.
NSAID tmt: 15-30 mg 1 x dly for 4 wks. If
necess. 4 wks more. Pts at risk or with
refract. ulc., longer tmt. and/or poss.
higher dose. Elderly: No adjust. reqd.
Pediatric: No experience.
Duod. ulc., benign gastric ulc., GERD,
erad. H. pylori; Zollinger Ellison synd/
other hypersecretory conds, NSAIDassoc.
benign gastric ulc., duod. ulc.,
relief sympts. in cont. NSAID tmt.