All the Therapeutic System Drugs
Folic Acid Analog. Methotrexate 25 mg/ml. VIAL (sol. for inj.): 25 mg/ ml X 2 ml, 4 ml,
8 ml, 20 ml, 40 ml. Dose must be ajust.
individ. for each pt. accord. to med.
cond. See lit.
Antineopl. Chemother.
Tmt. of gestational choriocarcinoma,
chorioadenoma destruens and
hydatidiform mole. Palliation of ALL. Tmt.
and proph. of menin. leukemia.
Greatest effect has been observed in
palliation of acute lymphoblast.(stemcell)
leukemias in child. In comb. with
other anticancer agents, may be used for
the induc. of remis.,but is most common.
used in the mainten. of induced remis.
May be used alone, or in comb. with other
antineoplastic drugs, in the manag. of
breast canc., epidermoid cancers of the
head and neck, lung cancer (partic.
squamous cell ,small cell types), bladder
cancer and osteogenic cancer. Tmt. of the
advan.stages (III and IV, Peter’s Staging
system) of lymphosarcoma, partic. in
child., and in advanced cases of mycosis
fungoides.
Psoriasis. Indic. only in the sympt. control
of sev. recalcitrant, disabling psoriasis
which is not adeq. responsive to other
forms of therapy, and only when the diag.
has been established, as by biopsy and/or
after dermat. consult. RA:Tmt. of selec.
adul.with sev. RA, only when the diag. has
been well established accord. to rheumat.
standards, with inadeq. response to other
forms of antirheum. ther., includ. full dose
NSAIDs and usually a trial of at least one
or more dis.-modif. antirheum. drugs.
C/I: Pregnancy, lact., pts. in poor state of
nutrition, sev. ren. impair. (crCL <20 ml/
min), sev. liver impair., bone marrow
hypoplasia, leucopenia,
thrombocytopenia, anemia, alcohol
abuse, hypersens. and lung toxic.due to
methotrexate, serious, acute or chronic
infect. such as tuberculosis and HIV,
ulcers of the oral cavity and known
active GI ulcer dis. Concur. vaccin. with
live vaccines.
Interleukin-6 Receptor Inhibitor. Tocilizumab 20 mg/ml, 162 mg / 0.9 ml. VIALS: 1, 4 x 80 mg/4 ml; 200mg/10 ml;
400 mg/20 ml.
RA : 8mg/kg bdy wt. I.V. 1 x every 4
weeks.
Pts. bdy wt. > 100 kg, dose exceed. 800
mg/infus. not recommend. See lit. SJIA:
<30 kg bdywt: 12 mg/kg bdywt, every
2 wks; ≥30 kg bdywt: 8 mg/kg bdywt,
every 2 wks.
Reduce signs/sympts. in adult pts with
mod-severe active rheum. arthrit. when
inad. response to one/more DMARDS or
TNF antags., or in pts unable to use
DMARDs. Can be used alone/in comb. with
methotrexate/other DMARDs. Reduce rate
progress. joint damage as measured by
X-ray, improve physic. funct. when in
combinat. methotrexate. Tmt. active
system. juv. idiopath. arthrit. in pts. > 2 yrs.
C/I: Hypersens., active severe infects.
Interleukin-6 Receptor Inhibitor. Tocilizumab 162 mg / 0.9 ml. PRE- FILLED SYRINGE.: 4 x 162 mg/0.9 ml
Inj. S.C. 162 mg once a week.
In comb. with MTX, for the tmt. of moder.-
severe active RA in adult pt. who have
either responded inadequate. to, or who
were intoler. to, prev. therapy with one or
more DMARDs or TNF antagonists. In
these pts., Tocilizumab can be given as
monother. in case of intolerance to MTX or
where continued tmt. with MTX is
inappropriate.
C/I: Hypersens., active severe infects.
