All the Active Ingredient Drugs
Folic Acid Analog. Methotrexate 25 mg/ml. VIAL (sol. for inj.): 25 mg/ ml X 2 ml, 4 ml,
8 ml, 20 ml, 40 ml. Dose must be ajust.
individ. for each pt. accord. to med.
cond. See lit.
Antineopl. Chemother.
Tmt. of gestational choriocarcinoma,
chorioadenoma destruens and
hydatidiform mole. Palliation of ALL. Tmt.
and proph. of menin. leukemia.
Greatest effect has been observed in
palliation of acute lymphoblast.(stemcell)
leukemias in child. In comb. with
other anticancer agents, may be used for
the induc. of remis.,but is most common.
used in the mainten. of induced remis.
May be used alone, or in comb. with other
antineoplastic drugs, in the manag. of
breast canc., epidermoid cancers of the
head and neck, lung cancer (partic.
squamous cell ,small cell types), bladder
cancer and osteogenic cancer. Tmt. of the
advan.stages (III and IV, Peter’s Staging
system) of lymphosarcoma, partic. in
child., and in advanced cases of mycosis
fungoides.
Psoriasis. Indic. only in the sympt. control
of sev. recalcitrant, disabling psoriasis
which is not adeq. responsive to other
forms of therapy, and only when the diag.
has been established, as by biopsy and/or
after dermat. consult. RA:Tmt. of selec.
adul.with sev. RA, only when the diag. has
been well established accord. to rheumat.
standards, with inadeq. response to other
forms of antirheum. ther., includ. full dose
NSAIDs and usually a trial of at least one
or more dis.-modif. antirheum. drugs.
C/I: Pregnancy, lact., pts. in poor state of
nutrition, sev. ren. impair. (crCL <20 ml/
min), sev. liver impair., bone marrow
hypoplasia, leucopenia,
thrombocytopenia, anemia, alcohol
abuse, hypersens. and lung toxic.due to
methotrexate, serious, acute or chronic
infect. such as tuberculosis and HIV,
ulcers of the oral cavity and known
active GI ulcer dis. Concur. vaccin. with
live vaccines.
Antimetabolite. Methotrexate 2.5 mg, 100 mg. TABS.: 50 x 2.5 mg. 1 tab 3 x per wk. 1hr
bef. food or 11/2-2 hrs. aft. See lit.
VIAL.: 5 ml, 10 ml, 50 ml ×100 mg/ml. I.M/I.V. Dosage must be ajust. individ. accord. indicat., gen. cond., blood counts.
Antineop. chemother.: tmt. of gestat.
choriocarcinoma, chorioadenoma
destruents and hydatidiform mole.
Palliation of acute lymphoc. leukemia.
Tmt. & prophylax. of meningeal
leukemia. Greatest effect has been
observed in palliation of acute lymphobl.
(stem cell) leukemias in child. In comb.
with other anticancer agents,
Induct. of remiss., but is most commonly
used in mainten. of induced remiss.
Abitrexate may be used alone or in comb.
with other antineopl. in the manag. of
breast cancer, epidermoid cancers of the
head &neck, lung cancer (particularly
squamous cell and small cell types),
bladder cancer and osteogeny. cancer.
Tmt. of the advanced stages (III and IV
Peter’s Staging Syst.) of lymphosarcoma,
particul. in child. , and in advanced cases
of mycosis fungoides.
Psoriasis: symptom. control of severe
recalcitrant, disabling psoriasis which is
not adequ. respons. to other forms of
ther., and only when the diagnosis has
been established, as by biopsy and/or
after dermatology. consultation.
RA: Tmt. of selected adults with severe
RA, only when the diagnosis has been
well established accord. to rheumatolog,
standards, with inadeq. response to other
forms of antirheumatic ther., includ. full
dose NSAIDs and usual. a trial of at least
one or more dis.-modif. antirheumatic
drugs.
C/I: Hypersens. Hep. insuffic. Alcohol
abuse. Renal insuffic. CrCl less than 20
ml/min. Pre-exist. blood dyscrasias, e.g.
bone marrow hypoplasia, leukopenia,
thrombocytopenia, or significant
anaemia. Serious, acute/ chron. infect.
such as tuberculosis , HIV. Ulcers of the
oral cavity and known active GI ulcer dis. Preg. Lact. Concur. vaccin. with live
vaccines.
Folic Acid Antagonist. Methotrexate 2.5 mg. TABS: 100 x 2.5 mg. See lit.
Neoplastic dis., psoriasis not respons. to
other forms ther.
Disease Modyfing Anti-Rheumatic. Methotrexate 50 mg/ml. PREFILL. PEN (sol. for inject.): 1, 4, 6, 12,
24 x 7.5 mg/0.15 ml, 10 mg/0.2 ml, 15
mg/0.3 ml, 20 mg/0.4 ml, 25 mg/0.5 ml.
S.C., I.M./I.V. See lit.
Rheumatoid arthrit. inadeq. respond. to
other forms of ther., psoriasis not
respons. to other ther. See lit.
Disease Modyfing Anti-Rheumatic. Methotrexate 50 mg/ml. PREFILL. SYR (sol. for inject.): 1, 4, 6, 12,
24 x 7.5 mg/0.15 ml, 10 mg/0.2 ml, 15
mg/0.3 ml, 20 mg/0.4 ml, 25 mg/0.5 ml.
S.C., I.M./I.V. See lit.
Rheumatoid arthrit. inadeq. respond. to
other forms of ther., psoriasis not
respons. to other ther. See lit.
