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  • Methotrexate
    5 Drugs classified under this active ingredient


    All the Active Ingredient Drugs

    Abitrexate
    Salomon, Levin & Elstein Ltd
    RX
    partial basket chart
    Abitrexate

    Folic Acid Analog. Methotrexate 25 mg/ml.
    VIAL (sol. for inj.): 25 mg/ ml X 2 ml, 4 ml,
    8 ml, 20 ml, 40 ml. Dose must be ajust.
    individ. for each pt. accord. to med.
    cond. See lit.
    Antineopl. Chemother.
    Tmt. of gestational choriocarcinoma,
    chorioadenoma destruens and
    hydatidiform mole. Palliation of ALL. Tmt.
    and proph. of menin. leukemia.
    Greatest effect has been observed in
    palliation of acute lymphoblast.(stemcell)
    leukemias in child. In comb. with
    other anticancer agents, may be used for
    the induc. of remis.,but is most common.
    used in the mainten. of induced remis.
    May be used alone, or in comb. with other
    antineoplastic drugs, in the manag. of
    breast canc., epidermoid cancers of the
    head and neck, lung cancer (partic.
    squamous cell ,small cell types), bladder
    cancer and osteogenic cancer. Tmt. of the
    advan.stages (III and IV, Peter’s Staging
    system) of lymphosarcoma, partic. in
    child., and in advanced cases of mycosis
    fungoides.
    Psoriasis. Indic. only in the sympt. control
    of sev. recalcitrant, disabling psoriasis
    which is not adeq. responsive to other
    forms of therapy, and only when the diag.
    has been established, as by biopsy and/or
    after dermat. consult. RA:Tmt. of selec.
    adul.with sev. RA, only when the diag. has
    been well established accord. to rheumat.
    standards, with inadeq. response to other
    forms of antirheum. ther., includ. full dose
    NSAIDs and usually a trial of at least one
    or more dis.-modif. antirheum. drugs.
    C/I: Pregnancy, lact., pts. in poor state of
    nutrition, sev. ren. impair. (crCL <20 ml/
    min), sev. liver impair., bone marrow
    hypoplasia, leucopenia,
    thrombocytopenia, anemia, alcohol
    abuse, hypersens. and lung toxic.due to
    methotrexate, serious, acute or chronic
    infect. such as tuberculosis and HIV,
    ulcers of the oral cavity and known
    active GI ulcer dis. Concur. vaccin. with
    live vaccines.

    Methotrexat “Ebewe”
    Pharmalogic
    RX
    partial basket chart
    Methotrexat “Ebewe”

    Antimetabolite. Methotrexate 2.5, 20, 100 mg.
    TABS.: 50 x 2.5 mg. 1 tab 3 x per wk. 1hr
    bef. food or 11/2-2 hrs. aft. See lit.
    VIAL.: 5 ml, 10 ml, 50 ml ×100 mg/ml. I.M/I.V. Dosage must be ajust. individ. accord. indicat., gen. cond., blood counts.
    PRE-FILL. SYR.: 1× 7.5mg/0.375ml,
    10mg/0.5ml, 12.5mg/0.625ml
    15mg/0.75ml, 17.5mg/0.875ml,
    20mg/1ml, 22.5mg/1.125ml and
    25mg/1.25ml. I.M./I.V./S.C.
    Dosage must be ajust. individ. accord.
    indicat., gen. cond., blood counts.
    Antineop. chemother.: tmt. of gestat.
    choriocarcinoma, chorioadenoma
    destruents and hydatidiform mole.
    Palliation of acute lymphoc. leukemia.
    Tmt. & prophylax. of meningeal
    leukemia. Greatest effect has been
    observed in palliation of acute lymphobl.
    (stem cell) leukemias in child. In comb.
    with other anticancer agents,
    Induct. of remiss., but is most commonly
    used in mainten. of induced remiss.
    Abitrexate may be used alone or in comb.
    with other antineopl. in the manag. of
    breast cancer, epidermoid cancers of the
    head &neck, lung cancer (particularly
    squamous cell and small cell types),
    bladder cancer and osteogeny. cancer.
    Tmt. of the advanced stages (III and IV
    Peter’s Staging Syst.) of lymphosarcoma,
    particul. in child. , and in advanced cases
    of mycosis fungoides.
    Psoriasis: symptom. control of severe
    recalcitrant, disabling psoriasis which is
    not adequ. respons. to other forms of
    ther., and only when the diagnosis has
    been established, as by biopsy and/or
    after dermatology. consultation.
    RA: Tmt. of selected adults with severe
    RA, only when the diagnosis has been
    well established accord. to rheumatolog,
    standards, with inadeq. response to other
    forms of antirheumatic ther., includ. full
    dose NSAIDs and usual. a trial of at least
    one or more dis.-modif. antirheumatic
    drugs.
    C/I: Hypersens. Hep. insuffic. Alcohol
    abuse. Renal insuffic. CrCl less than 20
    ml/min. Pre-exist. blood dyscrasias, e.g.
    bone marrow hypoplasia, leukopenia,
    thrombocytopenia, or significant
    anaemia. Serious, acute/ chron. infect.
    such as tuberculosis , HIV. Ulcers of the
    oral cavity and known active GI ulcer dis. Preg. Lact. Concur. vaccin. with live
    vaccines.

    Methotrexate
    Pfizer
    RX
    full basket chart
    Methotrexate

    Folic Acid Antagonist. Methotrexate 2.5 mg.
    TABS: 100 x 2.5 mg. See lit.
    Neoplastic dis., psoriasis not respons. to
    other forms ther.

    Metoject 50 mg/ml
    Tzamal
    RX
    not in the basket chart
    Metoject 50 mg/ml

    Disease Modyfing Anti-Rheumatic. Methotrexate 50 mg/ml.
    PREFILL. PEN (sol. for inject.): 1, 4, 6, 12,
    24 x 7.5 mg/0.15 ml, 10 mg/0.2 ml, 15
    mg/0.3 ml, 20 mg/0.4 ml, 25 mg/0.5 ml.
    S.C., I.M./I.V. See lit.
    Rheumatoid arthrit. inadeq. respond. to
    other forms of ther., psoriasis not
    respons. to other ther. See lit.

    Metoject 50 mg/ml S.C
    Tzamal
    RX
    not in the basket chart
    Metoject 50 mg/ml S.C

    Disease Modyfing Anti-Rheumatic. Methotrexate 50 mg/ml.
    PREFILL. SYR (sol. for inject.): 1, 4, 6, 12,
    24 x 7.5 mg/0.15 ml, 10 mg/0.2 ml, 15
    mg/0.3 ml, 20 mg/0.4 ml, 25 mg/0.5 ml.
    S.C., I.M./I.V. See lit.
    Rheumatoid arthrit. inadeq. respond. to
    other forms of ther., psoriasis not
    respons. to other ther. See lit.

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