Muscle Relaxants

All the Therapeutic System Drugs

Skeletal Muscle Relaxant. Baclofen 0.5 mg/ml , 2 mg/ml.
Amp. 1/5 X 0.5 mg per ml or 2 mg per ml for intrathecal inj.: Dose: see lit.
Pts. with sev. chron. spastic. resul. from trauma, MS or other spinal cord disord., who are unrespons. to oral baclofen or other oral antispastic agents and/or pts. who exper. unaccept. side effects at effect. oral doses.
In adult pt.s with sev. chron. spastic. of cerebr. origin, result. from CP, brain trauma or CVA; however, clinic. exper. is limited.
Pediatr. pop: in pts. aged 4 to <18 years with sev. chron. spastic. of cerebr. or spinal origin (assoc. with injury, MS, or other spinal cord dis.) who are unrespons. to oral antispast. (incl. oral baclofen) and/or who exper. unaccept. side effects at effect. oral doses.
C/I: hypersens.
Any route of admin. other than intrathecal.

Baclosal

Skeletal Muscle Relaxant. Baclofen 10 mg, 25 mg.
TABS: 50 x 10 mg, 25 mg. Initial: 5 mg 3
x dly., incr. at 3 day intervals up to
40-80 mg dly. in div. doses accord. to
individ. req.
Muscle spasticity of varying origin.
C/I: Hypersens.
Present/history of gastric ulc.

Botox

Bacterial Toxin. Botilium Toxin 50, 100, 200 U.
PWDR. FOR INJECT: 50, 100, 200 U/vial. Spasm. torticollis: 25-300 units accord. to
individ. req. Intervals of at least 10-12
wks. strabismus: 1.25-5 units accord. to
pt. req. Blepharospasm: 1.25-5 units.
Axillary hyperhidros: Max. 50 U to each
axilla. See lit.
Spasmod. torticollis (cervic. diston.).,
strabis. and blepharospasm
assoc. with
dyston., benign essential blepharospasm,
nerve VII disords. in pts. over 12 yrs.,
dynamic equinus foot deform. due to
spastic. in ped. cerebral palsy, focal upper
limb spasticity associat. with stroke. Temp.
improve. appearance mod. to severe
glabellar lines assoc. with corrugator and/
or procerus muscle activity in adult pts. 65
yrs. or less. Manage. prim. axillary
hyperhidros. in pts. not respond. other
medical symptomat. tmt.

Dysport

Botilium Toxin 300 U/vial, 500 U/vial.
VIALS (pwdr. for inject.): 1. Ped. cerebral
palsy: Initial: 20 units/kg bdy wt. (10
units/kg if only 1 calf is affected) to be inject. into calf muscle. Max. dose:
1,000 units/pt.; Spasmodic torticollis:
Initial: 500 units as a divided dose into
the 2 or 3 most active neck muscles.
Doses above 1,000 units not
recommend; Blepharospasm and
hemifacial spasm: Initial: 120 units/eye.
May be reduced on subsequent admin.
Not to be repeated more than every 8
wks. Adult arm spasm aft. stroke: 1,000
U. Axillary hyperhydros: Initial: 100 U/
axilla. Subseq. injects: 10 sites ea site
receiv. 10 units intraderm. If desired
effect not obtain: 200 U/axilla. Max.
effect aft. 2 wks. Provides protect. for
48 wks. See lit. Child: Safety and effect.
not been demonstrat. Mod-severe
glabellar lines: 50 U (0.25 ml) I.M. div.
into 5 inject. sites. See lit. May repeat
approx. every 16 wks. Interval betw.
inject: Not less than 3 mths. Child: Not
recommend. See lit.
Dynam. ft. deform. due to spasticity in
ambulant ped. C.P. 2 yrs and over,
spasmod. torticollis in adults,
blepharospasm and hemifacial spasm in
adults, adult arm spasticity post stroke.
Axillary hyperhydros., tmt. mod-severe
glabellar lines.
C/I: Pregn.

Muscol

Analgesic, Skeletal Muscle Relaxant. Orphenadrine (citrate) 30 mg, Paracetamol 500 mg.
TABS: 20. 2 tabs. 3 x dly.
Child over 5: 1/2 the dose.
Mild to mod. pain in acute musculoskelet.
disords.