Nucleoside Reverse Transcriptase Inhibitor

10 Drugs classified under this drug class

Nucleoside Reverse Transcriptase Inhibitor. Entecavir 0.5 mg, 1 mg.
TABS.:30: Compens. liver dis.: Nucleoside naive pts.: 0.5 mg×1/d, with/without food. Lamivudine-refractory pts.: 1 mg ×1/d, without food. Decompens. liver dis.: 1 mg ×1/d, without food. For pts. with lamivudine-refractory hepatitis B, see lit.
Tmt. of chronic HBV infec. in adults with: Compens. liver dis.  and evidence of active viral replic. persist. elevated serum ALT levels and histolog. evidence of active inflam. and/ or fibrosis. Decompens.  liver dis. For both compens. and decompens. liver dis. , this indic.  is based on clinical trial data in nucleoside naive pts. with HBeAg positive and HBeAg negative HBV infec.  With respect to pts. with lamivudine-refract. hepatitis B.
C/I: Hypersens., lact.

Nucleoside Reverse Transcriptase Inhibitor. Ribavirin 200 mg.
CAPS: 168. ≤75 kg: 1,000 mg dly; >75
kg: 1,200 mg dly in 2 div. doses.
In comb. with interferon Alfa-2b comb.
(intron A) inject. for chron. hepatit. C in
18 yrs or older with compensated liver
dis. previous. untreated with Alfa
interferon or foll. relapse aft. treat. with
Alfa interferon.

Nucleoside Reverse Transcriptase Inhibitor. Tenofovir Disoproxil 245 mg.
F.C. TABS: 30. 1 tab dly with food.
Tmt. of (1) HIV 1 infec. adults and ped. pts.
12 yrs. of age and older in comb. with
other antiretrov.med. prod. for the tmt. of
HIV;) chron. hep. B in adults with: compen.
liver dis., with evidence of act. viral
replicat., persist. elevated (ALT) levels and
histology. evidence of act. inflam. and/or
fibrosis, decompens. liver dis.
C/I: Hypersens. concom. use of other
drgs. contain tenofovir fumarate; comb.
with drgs. contain adefovir dipivoxil;
preg. ,lact.

Nucleoside Reverse Transcriptase Inhibitor. Abacavir (as sulfate) 300 mg, Lamivudine 150 mg, Zidovudine 300 mg.
F.C. TABS: 60. 1 tab 2 x dly with or
without food. Start tmt. with the 3
components separately for first 6-8
wks then transfer to fixed comb. Child.
under 18 yrs not recommend.
Tmt. of HIV infect. in adults.
C/I: Hypersens., espec. hypersensitivity
reactions, end-stage renal dis.;
neutrophil count < 0.75 x 10^9/l or
Hg. levels < 7.5g/dl or 4.65 mmol/l.

Nucleoside Reverse Transcriptase Inhibitor. Emtricitavine 200 mg, Tenofovir Disoproxil 245 mg.
F.C. TABS: 30. 1 tab dly with
food. Child: Under 18 yrs. not
recommend.
In comb. with other antiretrovirals to
treat HIV-1 infects.
C/I: Severe ren. impair., lact.

Nucleoside Reverse Transcriptase Inhibitor. Valaciclovir (HCl monohydrate) 500 mg.
F.C. TABS.:10, 42.
H. Zoster: 1000mg ×3/d for 7 d. H.
Simplex: 500mg, ×3/d for 5 d. In cases
of severe infec. tmt. can be extended
for up to 10 d. Preven. of recur. H.
Genitalis in immune-comp. pts.:
500mg×1/d Preven. of CMV infec. –
adult./child. from 12 yrs. of age: 2000
×4/d a day. Begin tmt. immediat. after
organ transplant. Tmt. of H. Labialis:
2000mg×2/d 12 hrs. apart, for one day.
Tmt. of H. Zoster in immune-compet.
adults that includes acute and post-herp.
neuralgia. Tmt. of the init. and recurrent H.
Genitalis due to H. Simplex infec.
Preven. (suppres.) of recur. H. Simplex
infec. (H. Genitalis). Prophyl. of CMV infect.
and dis., follow. organ transplant. Tmt. H.
labialis.
C/I: Hypersens. to Valaciclovir /Acyclovir.