All the biological system drugs
Nicotine Receptor Partial Agonist. Varenicline (as tartrate) 0.5 mg, 1 mg. Health basket inclusion: Champix will be given to the treatment of smoking cessation parallel to supportive means.
TABS: 55 x 0.5 mg, 56 x 1 mg; starter pack: 11 x 0.5 mg + 14, 28 x 1 mg.
Days 1 – 3: 0.5 mg ×1/d.
Days 4– 7: 0.5 mg ×2/d.
Day 8 – end of tmt.: 1 mg ×2/d.
Pts. should be treated with Varenicline for 12 wks. For pts. who have successf. stopped smok. at the end of 12 wks., an addit. course of 12 wks. tmt. with Varenicline is recomm. to further incr. the likelihood of long-term abstinence.
Pts. with ren. impair. No dosage adjust. is necessary for pts. with mild- moder. renal impair. For pts. with sev. renal impair. (estimated CrCl <30 mL/min), the recomm. start. dose of Varenicline is 0.5 mg ×1/d. The dose may then be titrated as needed to a max. dose of 0.5 mg×2/d. For pts. with end-stage renal dis. underg. hemodialysis, a max. dose of 0.5 mg mg×/d may be admin. if toler.
Aid to smoking cessat. for adults over 18
yrs.
C/I: Hypersens., known skin react. to varenicline
Alkaloid. Nicotine 2 mg, 4 mg. GUM (Fruit and mint): 48, 204 x 2 mg; 48
x 4 mg. 1 piece of gum on urge to
smoke. Usually 8-12 pieces req. dly.
Max: 25 pieces of 2 mg dly; 15 pieces of
4 mg dly.
Aid to smoking cessation.
Alkaloid. Nicotine 1 mg, 2 mg. Lozenges: 36 x 1 mg, 2 mg. 1-2 loz. every
1-2 hrs. Recommend: 8-12 loz dly. Max.
30 x 1 mg/15 x 2 mg dly.
For adults > 18 yrs. Aid to smoking
cessation. Also as part of program to
reduce smoking prior to stopping
completely. 1 mg: for smokers of < 20
cigarettes dly; 2 mg: for smokers of > 20
cigarettes dly.
C/I: Hypersens., non-smokers, <18 yrs,
phenylketonuria.
Drugs used in Alcohol Dependence. Nalmefene 18.06 mg (as hydrochloride dihydrate). F.C. TABS: 14. Administ. should be adjust.
individ, for each pt. accord. to its clin.
status, alcohol depend., level of alcohol
consump. Therap. must cont. under
const. superv. of specialist.
Max. Dose is 18.06 mg ×1/d, before or
after meal.
Reduc. of alcohol consump. in adult pts.
with alcohol depend. who have a high DRL,
without phys. withdrawal sympt. and who
do not require immed. detoxif.
Should only be used in conjunct.with
contin. psychosoc. support focused on tmt.
adherence and reduc. alcohol consump.
Should be init. only in pts. who cont. to have a high DRL two weeks after init.
assessment.
C/I: Hypersens. Pts. taking opioid agon. (e.g. opioid analg., opioids for substit. ther. with
opioid agon. (e.g. methadone) or part.
agon. (e.g. buprenorphine). Pts. with curr., recent opioid addic. Pts. with acute sympt. of opioid withdrawal. Pts. suspect. in recent use of opioids. Sev. hep.impair. Sev. ren. impair. (eGFR<30 ml/min per 1.73 m²).
Recent hist. of acute alcohol withdrawal
synd. (include. hallucin. seiz., delir.
tremens).
Opiod Dependency. Buprenorphine 8.64 mg, Naloxone HCl 2.44 mg. S.L. TAB. 7, 28.
The recommend. start. dose in adult.,
adolesc. over 15 yrs.: 1-2 tabs. of 2
mg/0.5 mg. An addit. 1-2 tabs. 2 mg/0.5
mg may be administ. on day one
depend. on the individ. pts. requirem.
Dose titrat. in steps of 2-8 mg is guided
by reassess. of the clinic. & psycholog.
status of the pt., and should not exceed
a max. single dly. dose of 24 mg.
Substit. tmt. for opioid drug dependence,
within a framework of med., social and
psycholog. tmt. in adult., adolesc. over 15
yrs. who have agreed to be treated for
addiction.
C/I: Hypersens., severe resp. insuffic.,
severe hepat. impair, acute alcoholism or
delirium tremens.
Partial Opioid Agonist/Antagonist. Buprenorphine (as HCl) 2 mg, 8 mg. TABS: 7 x 2 mg, 8 mg. See lit.
Substitut. tmt. opioid depend. within
framework of medical, social and
psycholog. tmt.
C/I: Hypersens., severe respir. insuffic.,
severe hepat. insuffic., acute alcoholism.,
delirium tremens, under 16 yrs., lact.
