All the biological system drugs
Opioid. Methadone HCl 40 mg/100 ml. LIQ: 100 ml. Dose must be adjust. individ. for each pt.
Gastro-intest. spasms, renal, biliary colic,
neuralg., gyne. pains, withdrawal tmt. of
morph. and pethidine addict., relief
C/I: Hypersens. Respir. depres. obstruct.
airw. dis.(espec.in the presence of
cyanos., exces. bronch. secret.), dur.
acute asth. Attack Pts. depend.on nonopioid
Concur. administ. with MAOIs (include.
moclobemide) or within 2 wks. of
discontin. of them. Head inj., raised
intracran. Pres Pts. with risk of paralyt.
ileus. Pts. with ulcer. colitis. Pts. with
sev. hep.impair. Acute alcoholism Use dur. labor. pts. with bil. ,renal tract
spasm. Use in Child.
Nicotine Receptor Partial Agonist. Varenicline (as tartrate) 0.5 mg, 1 mg. TABS: 55 x 0.5 mg, 56 x 1 mg; starter
pack: 11 x 0.5 mg + 14, 28 x 1 mg.
One wk. bef. preset date to start: Days
1-3: 0.5 mg 1 x dly. Days 4-7: 0.5 mg 2 x
dly. Days 8-end of tmt: 1 mg 2 x dly.
Taken aft. meal, swallow with full glass
of water. Tmt. should last 3-6 mths. See
Aid to smoking cessat. adults over 18
C/I: Not to pts. under 18 yrs, hypersens.
Alkaloid. Nicotine 1 mg, 2 mg. Lozenges: 36 x 1 mg, 2 mg. 1-2 loz. every
1-2 hrs. Recommend: 8-12 loz dly. Max.
30 x 1 mg/15 x 2 mg dly.
For adults > 18 yrs. Aid to smoking
cessation. Also as part of program to
reduce smoking prior to stopping
completely. 1 mg: for smokers of < 20
cigarettes dly; 2 mg: for smokers of > 20
C/I: Hypersens., non-smokers, <18 yrs,
Drugs used in Alcohol Dependence. Nalmefene 18.06 mg (as hydrochloride dihydrate). F.C.TABS:14. Administ. should be adjust.
individ, for each pt. accord. to its clin.
status, alcohol depend., level of alcohol
consump. Therap. must cont. under
const. superv. of specialist.
Max. Dose Is 18.06 mg ×1/d, before or
Reduc. of alcohol consump. in adult pts.
with alcohol depend. who have a high DRL,
without phys. withdrawal sympt. and who
do not require immed. detoxif.
Should only be used in conjunct.with
contin. psychosoc. support focused on tmt.
adherence and reduc. alcohol consump.
Should be init. only in pts. who cont. to have a high DRL two weeks after init.
C/I: Hypersens. Pts. taking opioid agon. (e.g. opioid analg., opioids for substit. ther. with
opioid agon. (e.g. methadone) or part.
agon. (e.g. buprenorphine) Pts. with curr. , recent opioid addic. Pts. with acute sympt. of opioid withdrawal. Pts. suspect. in recent use of opioids . Sev. hep.impair. Sev. ren. impair.(eGFR<30 ml/min per 1.73 m2).
Recent hist. of acute alcohol withdrawal
Opiod Dependency. Buprenorphine 8.64 mg, Naloxone HCl 2.44 mg. S.L. TAB. 7, 28.
The recommend. start. dose in adult.,
adolesc. over 15 yrs.: 1-2 tabs. of 2
mg/0.5 mg. An addit. 1-2 tabs. 2 mg/0.5
mg may be administ. on day one
depend. on the individ. pts. requirem.
Dose titrat. in steps of 2-8 mg is guided
by reassess. of the clinic. & psycholog.
status of the pt., and should not exceed
a max. single dly. dose of 24 mg.
Substit. tmt. for opioid drug dependence,
within a framework of med., social and
psycholog. tmt. in adult., adolesc. over 15
yrs. who have agreed to be treated for
C/I: Hypersens., severe resp. insuffic.,
severe hepat. impair, acute alcoholism or