All the Active Ingredient Drugs
Opioid. Buprenorphine 5, 10, 15, 20 mg. TRANSDERMAL 7-DAY MATRIX PATCHES:
Butrans 5: 2 x 5 mg/patch (5 μg/hr);
Butrans 10: 2 x 10 mg (10 μg/hr);
Butrans 15: 15 mg (15μg/hr);
Butrans 20: 2 x 20 mg (20 μg/hr).
Should be applied every 7 days.
Not for acute pain. Pts. aged 18 years and over:
initial: Butrans 5, depend. opioid hist.,
current gral.cond., medical status. Pts. should use usual recomm. doses of short-act.
suppl. analgesics as needed
until analgesic efficacy is attained.
Titrat.:
Dose may be titr. upwards as indic. after 3 d., when the max. effect of a given dose is establish. Subseq. dosage incr. may be based on the need for supplem. pain relief and the pt’s. analges. resp. to the patch.
To incr. the dose, a larger patch should repl. the current. one, or a comb. of patches should be appl. in differ. places to achieve desired dose. It is recomm. that no more than two patches are appl. at the same time, up to (and includ.) a max. total dose of 40mcg/h. A new patch should not be appl. to the same skin site for the subseq.3-4 wks. See lit.
Tmt. mod.-severe opioid respons. chron.
pain conds. not adequat. respond. to
non-opioid analges.
C/I:
Hypersens.
Opioid depend. pts. and for narcotic withdrawal tmt.
Condit. in which the respirat. centre and funct. are sever. impaired or may become so.
Pts. who are receiving MAO inhib. or have taken them within the last 2 wks.
Pts. suffer. from myasthenia gr.
Pts. suffer. from delirium tremens.
Opiod Dependency. Buprenorphine 8.64 mg, Naloxone HCl 2.44 mg. S.L. TAB. 7, 28.
The recommend. start. dose in adult.,
adolesc. over 15 yrs.: 1-2 tabs. of 2
mg/0.5 mg. An addit. 1-2 tabs. 2 mg/0.5
mg may be administ. on day one
depend. on the individ. pts. requirem.
Dose titrat. in steps of 2-8 mg is guided
by reassess. of the clinic. & psycholog.
status of the pt., and should not exceed
a max. single dly. dose of 24 mg.
Substit. tmt. for opioid drug dependence,
within a framework of med., social and
psycholog. tmt. in adult., adolesc. over 15
yrs. who have agreed to be treated for
addiction.
C/I: Hypersens., severe resp. insuffic.,
severe hepat. impair, acute alcoholism or
delirium tremens.
Partial Opioid Agonist/Antagonist. Buprenorphine (as HCl) 2 mg, 8 mg. TABS: 7 x 2 mg, 8 mg. See lit.
Substitut. tmt. opioid depend. within
framework of medical, social and
psycholog. tmt.
C/I: Hypersens., severe respir. insuffic.,
severe hepat. insuffic., acute alcoholism.,
delirium tremens, under 16 yrs., lact.
