All the Active Ingredient Drugs
Opioid. Buprenorphine 5, 10, 15, 20 mg. TRANSDERMAL 7-DAY MATRIX PATCHES:
Butrans 5: 2 x 5 mg/patch (5 μg/hr);
Butrans 10: 2 x 10 mg (10 μg/hr);
Bytrans 15: 15 mg (15μg/hr);
Butrans 20: 2 x 20 mg (20 μg/hr).
Should be applied every 7 days.
Not for acute pain. Patients aged 18 years and over: Initial: BuTrans 5,
depend. opioid history, current gen.
cond., medical status. Pts. should use
usual recommend. doses of short-act.
supplement. analgesics as needed
until analgesic effecacy is attained.
Titrat.: The dose may be titr. upwards as indic. after 3 d., when the max. effect of a
given dose is establish. Subsequent dosage increases may then be titrated based on the need for supplem. pain relief and the pt’s. analges. response to the patch.
To incr. the dose, a larger patch should replace the patch that is current. being
worn, or a comb. of patches should be appl. in differ. places to achieve the
desired dose. It is recom. that no more than two patches are appl. at the same
time, up to (and includ.) a max. total dose of 40mcg/h. A new patch should not
be appl. to the same skin site for the subseq.3-4 wks. See lit.
Tmt. mod.-severe opioid respons. chron.
pain conds. not adequat. respond. to
Hypersens. Opioid depend. pts. and for narcotic withdrawal tmt. Condit. in which the respirat. centre and funct. are sever. impaired or may become so. Pts. who are receiving MAO inhib. or have taken them within the last 2 wks. Pts.suffer. from myasthenia g. Pts.suffer. from delirium tremens.
Opiod Dependency. Buprenorphine 8.64 mg, Naloxone HCl 2.44 mg. S.L. TAB. 7, 28.
The recommend. start. dose in adult.,
adolesc. over 15 yrs.: 1-2 tabs. of 2
mg/0.5 mg. An addit. 1-2 tabs. 2 mg/0.5
mg may be administ. on day one
depend. on the individ. pts. requirem.
Dose titrat. in steps of 2-8 mg is guided
by reassess. of the clinic. & psycholog.
status of the pt., and should not exceed
a max. single dly. dose of 24 mg.
Substit. tmt. for opioid drug dependence,
within a framework of med., social and
psycholog. tmt. in adult., adolesc. over 15
yrs. who have agreed to be treated for
C/I: Hypersens., severe resp. insuffic.,
severe hepat. impair, acute alcoholism or
Partial Opioid Agonist/Antagonist. Buprenorphine (as HCl) 2 mg, 8 mg. TABS: 7 x 2 mg, 8 mg. See lit.
Substitut. tmt. opioid depend. within
framework of medical, social and
C/I: Hypersens., severe respir. insuffic.,
severe hepat. insuffic., acute alcoholism.,
delirium tremens, under 16 yrs., lact.