All the Active Ingredient Drugs
Opiod Dependency. Buprenorphine 8.64 mg, Naloxone HCl 2.44 mg. S.L. TAB. 7, 28.
The recommend. start. dose in adult.,
adolesc. over 15 yrs.: 1-2 tabs. of 2
mg/0.5 mg. An addit. 1-2 tabs. 2 mg/0.5
mg may be administ. on day one
depend. on the individ. pts. requirem.
Dose titrat. in steps of 2-8 mg is guided
by reassess. of the clinic. & psycholog.
status of the pt., and should not exceed
a max. single dly. dose of 24 mg.
Substit. tmt. for opioid drug dependence,
within a framework of med., social and
psycholog. tmt. in adult., adolesc. over 15
yrs. who have agreed to be treated for
C/I: Hypersens., severe resp. insuffic.,
severe hepat. impair, acute alcoholism or
Opioid. Oxycodone HCl 5, 10, 20, 30, 40 mg, Naloxone HCl 2.5, 5, 10, 15, 20 mg. P.R. TABS: 20 x 5 (oxycodone HCl 5 mg/naloxone HCl 2.5 mg); 10 (10 mg oxycodone HCl, 5 mg naloxone HCl); 20 (20 mg oxycodone HCl, 10 mg naloxone HCl); 30 (oxycodone HCL 30 mg, naloxone HCL 15 mg) 40 (oxycodone HCl 40 mg, naloxone HCl 20 mg). The analg. efficacy is equiv. to oxycodone HCL prolong. -release formul. The dosage should be adjust. to the intens. of pain and the sensitive. of the individ. pt.
Indic. for the relief of moder. -severe pain. The oxycodone compon. is indicated for the relief of moder.- sev. pain in adult. who require contin. around the-clock opioid analgesia for several days or more.
The opioid antag. naloxone is added to counteract opioid-induc. constip. by blocking the action of oxycodone at opioid recept. local. in the gut.
C/I: Hypersens. Severe respire. depress. with hypox. and/or hypercapnia. Severe COPD. Cor pulmonale. Severe bronch. asthma. Non-opioid induc. paralytic ileus. Moder.-sev. hep. impair.