• Home
  • A-B index
  • Pharmacological Index
  • Drug Classes
  • Active Ingredients
  • Companies
  • News
  • Pfizer Pharmaceuticals Israel Ltd


    Drugs Disributed by Pfizer Pharmaceuticals Israel Ltd

    Aldactone
    Pfizer
    RX
    full basket chart
    Aldactone

    Aldosterone Antagonist. Spironolactone 25 mg.
    TABS: 20 x 25 mg. 50-100 mg dly.
    Congest. card. fail. with oedema
    For manag. of edema an init. dly. dose
    of 100 mg of spironolactone admin. in
    either single or divided doses is
    recom., but may range from 25 mg-
    200 mg dly. Mainten. dose should be
    individ. determin.
    Pts. who tolerate 25 mg once dly. may
    have their dose incr. to 50 mg×1/d. as
    clinic. indic. Pts. who do not tolerate
    25mg ×1/d may have their dose
    reduced to 25 mg every other d.
    Admin. with food.
    Congest. heart fail; Cirrhot. ascites.
    C/I: Acute renal insuffic. , signific. renal
    compromise, anuria; Addison’s dis.;
    Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
    eplerenone or other K+ spar. diuret.;
    Ped. pts. with moder.- sev. renal impair.;
    Concom. use with other K+conserve.
    diuret., K+supplem. should not be given
    routin. with Aldactone as hyperkalaem.
    may be induced.

    Aromasin
    Pfizer
    RX
    partial basket chart
    Aromasin

    Aromatase Inhibitor. Exemestane 25 mg.
    TABS: 30. 1 tab (25 mg) dly. aft. meals.
    See lit.
    Advanced breast cancer (ABC) in women
    with natural/induced post-menopaus.
    status (progress. foll. anti-estrogen ther.
    alone) and in post-menopaus. women
    (progress. foll. multiple hormonal
    therapies). Adjuv. tmt post-menopaus.
    women with estrogen receptor pos. invas.
    early breast cancer foll. 2-3 yrs of initial
    adjuv. ther.
    C/I: Hypersens., premenopaus., pregn.,
    lact.

    Azenil Capsules
    Pfizer
    RX
    partial basket chart
    Azenil Capsules

    Macrolide. Azithromycin 250 mg.
    CAPS: 6 x 250mg.
    Adult.:
    Tmt. of STD caused by Chlamydia trachomatis: 1000 mg as a single oral dose. For all other indications in which the oral formul. is admin., the total dosage of 1500 mg should be given as 500 mg dly. for 3 d. As an alternative, the same total dose can be given over 5 d. with 500 mg given on 1st day, then 250 mg dly. on 2nd to 5th d.
    Child.:
    Child. ≥ 45kg , adult., includ. elderly pts.: The total dose of azithromycin is 1500mg which should be given over three days (500mg once daily).
    In uncomplic. genit. infec. due to Chlamydia trachomatis, the dose is 1000mg as a single oral dose.
    In general, the total dose in child. is 30 mg/kg. Tmt. for ped. streptococcal pharyngit. should be dosed at a different regim.
    The total dose of 30 mg/kg should be given as a single dly. dose of 10 mg/kg dly. for 3 d, or given over 5 d with a single dly. dose of 10 mg/kg on 1st d., then 5 mg/kg on 2nd -5th d.
    As an alternative to the above dosing, tmt. for child. with acute otit. med. can be given as a single dose of 30 mg/kg.
    For ped. streptococcal pharyngit., azithromycin given as a single dose of 10 mg/kg or 20 mg/kg for 3 d. has been shown to be effective; however, a daily dose of 500 mg must not be exceed.
    For child. weighing less than 15 kg, azithromycin susp. should be measured as closely as possib. For child. weighing 15 kg or more, azithromycin susp. See lit.
    Infec. caused by suscept. organis. in lower respire. tract include. bronchitis and pneum., skin&soft tissue infec., otitis med., upper respire. tract infec. includ. sinusitis & pharyngitis, tonsilitis, also in the tmt. of uncomplic. genit. infec. due to chlamydia trachomatis.
    C/I: Hypersens. to azithromycin, erythromycin, any macrolide or ketolide drug. Pts. with a history of cholestatic jaundice/hep. dysfunc. assoc. with prior use of azithromycin.

    Azenil Suspension
    Pfizer
    RX
    partial basket chart
    Azenil Suspension

    Macrolide. Azithromycin 200 mg / 5 ml.
    SUSP.: 15, 22.5ml × 200mg/5ml.
    Adult.:
    Tmt. of STD caused by Chlamydia trachomatis: 1000 mg as a single oral dose. For all other indications in which the oral formul. is admin., the total dosage of 1500 mg should be given as 500 mg dly. for 3 d. As an alternative, the same total dose can be given over 5 d. with 500 mg given on 1st day, then 250 mg dly. on 2nd to 5th d.
    Child.:
    Child. ≥ 45kg , adult., includ. elderly pts.: The total dose of azithromycin is 1500mg which should be given over three days (500mg once daily).
    In uncomplic. genit. infec. due to Chlamydia trachomatis, the dose is 1000mg as a single oral dose.
    In general, the total dose in child. is 30 mg/kg. Tmt. for ped. streptococcal pharyngit. should be dosed at a different regim.
    The total dose of 30 mg/kg should be given as a single dly. dose of 10 mg/kg dly. for 3 d, or given over 5 d with a single dly. dose of 10 mg/kg on 1st d., then 5 mg/kg on 2nd -5th d.
    As an alternative to the above dosing, tmt. for child. with acute otit. med. can be given as a single dose of 30 mg/kg.
    For ped. streptococcal pharyngit., azithromycin given as a single dose of 10 mg/kg or 20 mg/kg for 3 d. has been shown to be effective; however, a daily dose of 500 mg must not be exceed.
    For child. weighing less than 15 kg, azithromycin susp. should be measured as closely as possib. For child. weighing 15 kg or more, azithromycin susp. See lit.
    Infec. caused by suscept. organis. in lower respire. tract include. bronchitis and pneum., skin&soft tissue infec., otitis med., upper respire. tract infec. includ. sinusitis & pharyngitis, tonsilitis, also in the tmt. of uncomplic. genit. infec. due to chlamydia trachomatis.
    C/I: Hypersens. to azithromycin, erythromycin, any macrolide or ketolide drug. Pts. with a history of cholestatic jaundice/hep. dysfunc. assoc. with prior use of azithromycin.

    Benefix
    Pfizer
    RX
    partial basket chart
    Benefix

    Blood Coagulant. Coagulation factor IX recombinant - Rfix 250, 500, 1000, 2000 IU.
    VIAL (lyophilized pwdr. for injec.): 1×
    250 IU, 500 IU, 1000 IU, 2000 IU.
    IV use only after reconst., dosage must
    be adjust. individ. for each pt. See lit.
    Control/prevent. of hemorrh. epis. in pts
    with hemoph. B (cong. factor IX defic./
    Christmas dis.), incl. control/prevent. of
    bleed. in surg. settings, in prev. treat. pts /
    prev. untreat. pts. Not indicat. for the tmt
    of other factor defic. (e.g. factors II,VII,
    and X), nor for the tmt of hemoph. A, pts
    with inh. to factor VIII, nor for the revers.
    of coumarin-ind. anticoagul., nor for the
    tmt of bleed. due to low levels of liverdepend. coagul. factors.
    C/I: Pts with manifest. life-threat.,
    immed. hypersensitivity react., incl.
    anaphylaxis, to the product/compon.,
    incl. hamster protein.

    Besponsa
    Pfizer
    RX
    partial basket chart
    Besponsa

    Monoclonal Antibody. Inotuzumab Ozogamicin 1 mg/vial.
    VIAL(pwdr. for concentrat. for sol. for infus.): 1. The drug should be admin. in 3- to 4-wk. cycles.
    For pts. proceed. to haematopoietic stem cell transplant (HSCT), the recommend. duration of tmt. is 2 cycles. A 3rd cycle may be consid. for those pts. who do not achieve a complete remis. (CR) or complete remiss. with incomp. haematolog. recovery (CRi) and min. residual dis. (MRD) negative. after 2 cycles. For pts. not proceed. to HSCT, addit. cycles of tmt, up to a max. of 6 cycles, may be admin. Pts. who do not achieve a CR/CRi within 3 cycles should discont. tmt.
    For the 1st t cycle, the recomm. total dose: Inotuzumab ozogamicin for all pts. is 1.8 mg/m² per cycle, given as 3 divid. doses on Days 1 (0.8 mg/m²), 8 (0.5 mg/m²), and 15 (0.5 mg/m²). Cycle 1 is 3 wks. in durat., but may be extend. to 4 wks. if the pt. achieves a CR or CRi, and/or to allow recovery from toxicity.
    For subseq. cycles, the recomm. total dose: Inotuzumab ozogamicin is 1.5 mg/m² per cycle given as 3 divided doses on Days 1 (0.5 mg/m²), 8 (0.5 mg/m²), and 15 (0.5 mg/m²) for pts. who achieve a CR/CRi or 1.8 mg/m² per cycle given as 3 divided doses on Days 1 (0.8 mg/m²), 8 (0.5 mg/m²), and 15 (0.5 mg/m²) for pts. who do not achieve a CR/CRi. Subseq. cycles are 4 wks. in durat.
    Dose modific. may be required based on individ. safety and tolerab. Manag. of some ADR's. See lit.
    Indic. as monother. for the tmt. of adult. with relapsed or refract. CD22-posit. B cell precurs. acute lymphoblast. leuk. (ALL). Adult pts. with Philadelphia chromosome posit. (Ph+) relapsed or refract. B cell precursor ALL should have failed tmt. with at least 1 tyrosine kinase inhib.(TKI).
    C/I: Hypersens. Pts. who have experienc. prior confirm. severe or ongoing venoocclusive hep. dis. /sinusoidal obstruct. syndr. (VOD/SOS). Pts. with serious ongoing hep. dis.e.g., cirrhosis, nodular regenerative hyperplasia, active hepatitis).

    CLOSE