Pfizer Pharmaceuticals Israel Ltd

Bacterial and Viral Vaccines. RSV F antigen, A+B subgroups 60+60 mcg/ 0.5 ml.
Powder and solv. for sol. for IM inject. (60+60 mcg/vial) 1/5/10 doses
A sgle. dose of 0.5 ml to be admin to pregn. women between weeks 24-36  and to persons aged >60. See lit.
• Pass. protect.against lower respir. tract dis. caused by respir. syncytial virus (RSV) in infants from birth through 6 mo. of age following maternal immunisat. during pregn. • Active immunisat. of 60 years of age and older for the prevent. of lower respir. tract disease caused by RSV.
C/I: Hypersens.

Aldosterone Antagonist. Spironolactone 25 mg.
TABS: 20 x 25 mg. 50-100 mg dly.
Congest. card. fail. with oedema
For manag. of edema an init. dly. dose
of 100 mg of spironolactone admin. in
either single or divided doses is
recom., but may range from 25 mg-
200 mg dly. Mainten. dose should be
individ. determin.
Pts. who tolerate 25 mg once dly. may
have their dose incr. to 50 mg×1/d. as
clinic. indic. Pts. who do not tolerate
25mg ×1/d may have their dose
reduced to 25 mg every other d.
Admin. with food.
Congest. heart fail; Cirrhot. ascites.
C/I: Acute renal insuffic. , signific. renal
compromise, anuria; Addison’s dis.;
Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
eplerenone or other K+ spar. diuret.;
Ped. pts. with moder.- sev. renal impair.;
Concom. use with other K+conserve.
diuret., K+supplem. should not be given
routin. with Aldactone as hyperkalaem.
may be induced.

Aromatase Inhibitor. Exemestane 25 mg.
TABS: 30. 1 tab (25 mg) dly. aft. meals.
See lit.
Advanced breast cancer (ABC) in women
with natural/induced post-menopaus.
status (progress. foll. anti-estrogen ther.
alone) and in post-menopaus. women
(progress. foll. multiple hormonal
therapies). Adjuv. tmt post-menopaus.
women with estrogen receptor pos. invas.
early breast cancer foll. 2-3 yrs of initial
adjuv. ther.
C/I: Hypersens., premenopaus., pregn.,
lact.

Macrolide. Azithromycin 250 mg.
CAPS: 6 x 250mg.
Adult.:
Tmt. of STD caused by Chlamydia trachomatis: 1000 mg as a single oral dose. For all other indications in which the oral formul. is admin., the total dosage of 1500 mg should be given as 500 mg dly. for 3 d. As an alternative, the same total dose can be given over 5 d. with 500 mg given on 1^st day, then 250 mg dly. on 2^nd to 5^th d.
Child.:
Child. ≥ 45kg , adult., includ. elderly pts.: The total dose of azithromycin is 1500mg which should be given over three days (500mg once daily).
In uncomplic. genit. infec. due to Chlamydia trachomatis, the dose is 1000mg as a single oral dose.
In general, the total dose in child. is 30 mg/kg. Tmt. for ped. streptococcal pharyngit. should be dosed at a different regim.
The total dose of 30 mg/kg should be given as a single dly. dose of 10 mg/kg dly. for 3 d, or given over 5 d with a single dly. dose of 10 mg/kg on 1^st d., then 5 mg/kg on 2^nd -5^th d.
As an alternative to the above dosing, tmt. for child. with acute otit. med. can be given as a single dose of 30 mg/kg.
For ped. streptococcal pharyngit., azithromycin given as a single dose of 10 mg/kg or 20 mg/kg for 3 d. has been shown to be effective; however, a daily dose of 500 mg must not be exceed.
For child. weighing less than 15 kg, azithromycin susp. should be measured as closely as possib. For child. weighing 15 kg or more, azithromycin susp. See lit.
Infec. caused by suscept. organis. in lower respire. tract include. bronchitis and pneum., skin&soft tissue infec., otitis med., upper respire. tract infec. includ. sinusitis & pharyngitis, tonsilitis, also in the tmt. of uncomplic. genit. infec. due to chlamydia trachomatis.
C/I: Hypersens. to azithromycin, erythromycin, any macrolide or ketolide drug. Pts. with a history of cholestatic jaundice/hep. dysfunc. assoc. with prior use of azithromycin.

Macrolide. Azithromycin 200 mg / 5 ml.
SUSP.: 15, 22.5ml × 200mg/5ml.
Adult.:
Tmt. of STD caused by Chlamydia trachomatis: 1000 mg as a single oral dose. For all other indications in which the oral formul. is admin., the total dosage of 1500 mg should be given as 500 mg dly. for 3 d. As an alternative, the same total dose can be given over 5 d. with 500 mg given on 1^st day, then 250 mg dly. on 2^nd to 5^th d.
Child.:
Child. ≥ 45kg , adult., includ. elderly pts.: The total dose of azithromycin is 1500mg which should be given over three days (500mg once daily).
In uncomplic. genit. infec. due to Chlamydia trachomatis, the dose is 1000mg as a single oral dose.
In general, the total dose in child. is 30 mg/kg. Tmt. for ped. streptococcal pharyngit. should be dosed at a different regim.
The total dose of 30 mg/kg should be given as a single dly. dose of 10 mg/kg dly. for 3 d, or given over 5 d with a single dly. dose of 10 mg/kg on 1^st d., then 5 mg/kg on 2^nd -5^th d.
As an alternative to the above dosing, tmt. for child. with acute otit. med. can be given as a single dose of 30 mg/kg.
For ped. streptococcal pharyngit., azithromycin given as a single dose of 10 mg/kg or 20 mg/kg for 3 d. has been shown to be effective; however, a daily dose of 500 mg must not be exceed.
For child. weighing less than 15 kg, azithromycin susp. should be measured as closely as possib. For child. weighing 15 kg or more, azithromycin susp. See lit.
Infec. caused by suscept. organis. in lower respire. tract include. bronchitis and pneum., skin&soft tissue infec., otitis med., upper respire. tract infec. includ. sinusitis & pharyngitis, tonsilitis, also in the tmt. of uncomplic. genit. infec. due to chlamydia trachomatis.
C/I: Hypersens. to azithromycin, erythromycin, any macrolide or ketolide drug. Pts. with a history of cholestatic jaundice/hep. dysfunc. assoc. with prior use of azithromycin.

Blood Coagulant. Coagulation factor IX recombinant - Rfix 250, 500, 1000, 2000 IU.
VIAL (lyophilized pwdr. for injec.): 1×
250 IU, 500 IU, 1000 IU, 2000 IU.
IV use only after reconst., dosage must
be adjust. individ. for each pt. See lit.
Control/prevent. of hemorrh. epis. in pts
with hemoph. B (cong. factor IX defic./
Christmas dis.), incl. control/prevent. of
bleed. in surg. settings, in prev. treat. pts /
prev. untreat. pts. Not indicat. for the tmt
of other factor defic. (e.g. factors II,VII,
and X), nor for the tmt of hemoph. A, pts
with inh. to factor VIII, nor for the revers.
of coumarin-ind. anticoagul., nor for the
tmt of bleed. due to low levels of liverdepend. coagul. factors.
C/I: Pts with manifest. life-threat.,
immed. hypersensitivity react., incl.
anaphylaxis, to the product/compon.,
incl. hamster protein.