All the biological system drugs
Antibiotics. Amphotericin B 5mg/ml. VIAL (Concent. for susp.for infus.):
10×20ml. IV infus. at 5 mg/kg at a rate of
2.5 mg/kg/hr. See lit.
Tmt. of sev. invas. candidiasis. As 2nd line
therapy for the tmt. of sev. syst. fungal
infec. in pts. who have not responded to
conventional amphotericin B or other
syst. antifung. agents, in those who have
renal impair. or other contra-indic. to
conventional amphotericin B, or in pts.
who have developed amphotericin B
As 2nd line tmt. for invas. aspergillosis,
cryptococcal meningitis and
disseminated cryptococcosis in HIV pts.,
fusariosis, coccidiomycosis, zygomycosis
Anti-Androgen. Abiraterone Acetate 250 mg. TABS.: 120.
Intended for male pts. only. 1,000 mg (4×250mg tabs.) once dly. in comb. with prednisone.
Indicated in comb. with prednisone for the tmt. of pts. with metastat. castration-resist. prostate cancer.
C/I: Hypersensitivity to active substance or any of its excipients. Use in female patients. Severe hepatic impairment.
Folic Acid Analog. Methotrexate 25 mg/ml. VIAL (sol. for inj.): 25 mg/ ml X 2 ml, 4 ml,
8 ml, 20 ml, 40 ml. Dose must be ajust.
individ. for each pt. accord. to med.
cond. See lit.
Tmt. of gestational choriocarcinoma,
chorioadenoma destruens and
hydatidiform mole. Palliation of ALL. Tmt.
and proph. of menin. leukemia.
Greatest effect has been observed in
palliation of acute lymphoblast.(stemcell)
leukemias in child. In comb. with
other anticancer agents, may be used for
the induc. of remis.,but is most common.
used in the mainten. of induced remis.
May be used alone, or in comb. with other
antineoplastic drugs, in the manag. of
breast canc., epidermoid cancers of the
head and neck, lung cancer (partic.
squamous cell ,small cell types), bladder
cancer and osteogenic cancer. Tmt. of the
advan.stages (III and IV, Peter’s Staging
system) of lymphosarcoma, partic. in
child., and in advanced cases of mycosis
Psoriasis. Indic. only in the sympt. control
of sev. recalcitrant, disabling psoriasis
which is not adeq. responsive to other
forms of therapy, and only when the diag.
has been established, as by biopsy and/or
after dermat. consult. RA:Tmt. of selec.
adul.with sev. RA, only when the diag. has
been well established accord. to rheumat.
standards, with inadeq. response to other
forms of antirheum. ther., includ. full dose
NSAIDs and usually a trial of at least one
or more dis.-modif. antirheum. drugs.
C/I: Pregnancy, lact., pts. in poor state of
nutrition, sev. ren. impair. (crCL <20 ml/
min), sev. liver impair., bone marrow
thrombocytopenia, anemia, alcohol
abuse, hypersens. and lung toxic.due to
methotrexate, serious, acute or chronic
infect. such as tuberculosis and HIV,
ulcers of the oral cavity and known
active GI ulcer dis. Concur. vaccin. with
Monoclonal Antibody. Brentuximab Vedotin 50 mg. VIAL (Pwdr. for conc. for solution for IV infus.): 1 x 50 mg. The recom. dose is 1.8 mg/kg administ. as an IV infus. over 30 min. every 3 wks. If the pt. weight >100 kg, the dose calcul. should use 100 kg. Tmt. should be cont. until dis. progress. or unaccep.tox. Pts. who achieve stab. dis. or better should receive a minim. of 8 cycles and up to a max. of 16 cycles (approx. 1 year). Pts. with CTCL should receive up to 16 cycles. Dose should be individ. ajust in pts. with new or worsen. periph. sens./motor neuropath., neutpropen. The recomm. start. dose in pts with sev. renal impair or hep. impair. is 1.2 mg/ kg admin. as IV infus. over 30 min. every 3 wks. See lit.
Tmt. of adult pts. with relapsed or refractory CD30+ Hodgkin lymphoma (HL). Follow. autologous stem cell transplant (ASCT) or follow. at least two prior therapies when ASCT or multi-agent chemother. is not a tmt. option. Tmt. of adult pts. with CD30+ HL at incr. risk of relapse or progress. follow. ASCT. Tmt. of adult pts. with relapsed or refract. system. anaplastic large cell lymphoma (sALCL). Tmt. of adult pts. with CD30+ cutaneous T-cell lymphoma (CTCL) after at least 1 prior syst. ther.
C/I: Hypersens., comb. use with Bleomycin.
Protein Kinase Inhibitor. Everolimus 2.5, 5, 10 mg. TABS: 30 x 2.5 mg, 5 mg, 10 mg. Tmt. to
be initiated by physician experienced
in the use of anticancer ther. Orally
once dly., at the same time ev. d. See
Tmt. pts. with advanced ren. cell
carcinoma aft. fail. of tmt. with sunitinib or
sorafenib. Tmt. pts. with SEGA assoc. with
tuberous sclerosis complex who req. ther.
but not candidates for curative surg.
resect. Effect. based on analys. of change
in SEGA vol. Clin. benefit in improvement
dis.-relat,. sympts/increase in overall
survival has not been demonstrat. Tmt.
progress. neuroendocrine tumors
pancreat. origin in pts. with unresect.,
locally advanced/metastat. dis. Safety/
effectivenss in tmt. carcinoid tumors have
not been established. Tmt. of horm.
receptor-pos., HER2/neu neg. advanc.
breast canc. in combi. with exemestane in
postmen. women w/o symp. visceral dis.
after recur. or progress. following nonsteroid.
aromat. inh.. Tmt. of adult pts.
with renal angiomyolipoma and tuberous
sclerosis comp., nor req. immediate surg.
Effectiv. of the drug in tmt. of renal
angiomyolipoma based on an analysis of
durable obj. respons. in pts. treat. for a
median of 8.3 mnths. Further follow-up of
pts. is req. to determine long-term
Tmt. of unresect., local. advanc. /metastat.,
well-different. (Grade 1/ Grade 2) nonfunct.
neuroendocrine tumour. of GI or
lung origin in adults with progress. dis.
C/I: Hypersens. to active substances,
other rapamycin derivs., excips.