Androgen Biosynthesis Inhibitor

4 Drugs classified under this drug class

Androgen Biosynthesis Inhibitor. Abiraterone Acetate 250 mg , 500 mg.
TABS.: 250 mg x 120 , 500 mg x 60.
Intended  for male pts. only. 1,000 mg (4×250mg tabs. or 2x500mg tabs.) once dly.
 1. in combin. with prednisone for metast. castrat.-resist. prostate cancer.
2. For newly diag. high risk metast. hne. sensit. prostate cancer (mHSPC) in adlt. men in combinat. with androgen depriv. ther.(ADT) and in combin. with prednisone.
C/I:  Hypersens./ by pregn. females or who may be potent. pregn../sev. hepat. impairm./ in combin. with Ra-223 if given with prednisone.

Androgen Biosynthesis Inhibitor. Abiraterone Acetate 250 mg.
Tab 120 X 250 mg
1000 mg/d (4 tab.), once/d in comb. with oral prednisone 5 mg (twice/d for metast. CRPC and once/d for High risk mHSPC)
In comb. with prednisone for tmt. of metast. castr.-resist. prostate cancer (CRPC)
newly diagn. high risk metast. hormone-sensit. prostate
cancer (mHSPC) in adlt men in comb. with androgen depriv. ther.(ADT).  
C/I: Hypersens./Women/Sev. liver damage/In comb. with Ra-223

(ADP-ribose) polymerase (PARP) inhibitor, Androgen Biosynthesis Inhibitor. niraparib 50 mg, 100 mg, Abiraterone Acetate 500 mg.
niraparib 100 or 50 mg (as tosylate monohydrate) and 500 mg abiraterone acetate equiv. to 446 mg of abiraterone
FC Tabs. 56 X (100 mg and 500 mg)  and 56 x X (50 mg and 500 mg )
Recomm. starting dose is 200 mg/1000 mg (two 100 mg niraparib/500 mg abiraterone acetate tab.), as a sgle dly dose at approx. the same time every day. The 50 mg/500 mg tab. is available for dose reduction. Treat until dis. progress. or unaccept. tox.
 With prednisone or prednisolone for adults with metast. castration-resistant prostate cancer (mCRPC) and BRCA 1/2 mutations (germline and/or somatic) in whom chemother. is not clinically indicated.
C/I:  Hypersens. Women who are or may become pregnant.
Sev. hepatic impairm. (Child-Pugh Class C ).
This drug plus prednisone or prednisolone is contraindic. in combin. with Ra-223.

Androgen Biosynthesis Inhibitor. Abiraterone Acetate 250 mg.
TABS: 120 x 250 mg. Recomm. dose
1000 mg (4 x 250 mg tab.) once dly in
comb. with prednisone. See lit.
CYP 17 inhibitor, in comb. with prednisone
for tmt. of pts. with metastatic castrationresist.
prostate cancer.
C/I: Hypersens.; Pregn.; Sev. hep. impair.
(Child-Pugh Class C).