Alkylating Agent (platinum analog)

7 Drugs classified under this drug class

Alkylating Agent (platinum analog). Cisplatin 1 mg/ml.
VIALS: 1 x 100 ml, 50 ml. See lit.
Palliative in add. to other modalities
in
tmt. metastat. testic. and ovar. cancer,
advanced bladder cancer.

Alkylating Agent (platinum analog). Carboplatin 10 mg/ml.
VIALS (Conc. for sol. for infus.): 1 x 5 ml,
15 ml, 45 ml, 60 ml. Dosage must be
ajust. individ. accord. to pt. med. cond.
Advanced ovar. carcinoma in initial tmt.
and secondary tmt. Metastatic small cell
carcinoma of the lung.
C/I: Severe renal impair. (CrCL< 20 ml/
min), severe myelosuppress., Hypersens.
to platinum compounds or mannitol,
pts with bleeding tumours, lact.

Alkylating Agent (platinum analog). Carboplatin 10 mg/ml.
VIALS: 1 x 15 ml, 45 ml. In prev. untreat.
adults with normal ren. funct: 400 mg/
m2 as I.V. short-term infus. (15-60 min).
Can repeat cycle aft. 4 wks ther. free
interval. See li.
Alone or in comb. with other antineoplast.
agents in tmt. advanced ovar. carcinoma,
metastat. small cell lung cancer.
C/I: Hypersens., pregn., lact., severe
myelo-suppress., ren. impair., hear.
impair. See lit.

Alkylating Agent (platinum analog). Oxaliplatin 5 mg/ml.
SOLN (conc. for infus.): 10 ml, 20 ml, 40 ml. Adults only. Adjuv. setting: 85 mg/m2 I.V. every 2 wks for 12 cycles (6 mths). Metastat. colorect. cancer: 85 mg/m2 I.V. every 2 wks.
In comb. with fluorouracil and folic acid for adjuv. tmt. stage III (Duke’s C) colon cancer aft. complete resect. prim. tumor, metastat. colorect. cancer.

Alkylating Agent (platinum analog). Oxaliplatin 50, 100, 150 mg.
VIAL: 1 x 50 mg, 100 mg, 150 mg
(reconstitut. soln: 5 mg/ml oxaliplatin).
Adults only. Adjuv. setting: 85 mg/m2
I.V. Repeat every 2 wks. for 12 cycles (6
mths). Metastat. colorect. cancer: 85
mg/m2 I.V. Repeat every 2 wks. Adjust
dose accord. tolerability. Always
admin. bef. fluoropyramidines. See lit.
In comb. with 5-fluorouracil and folinic
acid for adjuv. tmt. stage III (Duke’s C)
colon cancer aft. complete resect. primary
tumor, tmt. metastat. colorect. cancer.
C/I: Hypersens., lact., myelosuppress.
prior to 1st course. See lit.

Alkylating Agent (platinum analog). Oxaliplatin 50, 100, 150 mg.
VIAL: 1 x 50 mg, 100 mg, 150 mg
(reconstitut. soln: 5 mg/ml oxaliplatin).
Adults only. Adjuv. setting: 85 mg/m²
I.V. Repeat every 2 wks. for 12 cycles (6
mths). Metastat. colorect. cancer: 85
mg/m2 I.V. Repeat every 2 wks. Adjust
dose accord. tolerability. Always
admin. bef. fluoropyramidines. See lit.
In comb. with 5-fluorouracil (5-FU) and
folinic acid for adjuv. tmt. stage III (Duke’s
C) colon cancer aft. complete resect.
primary tumor, tmt. metastat. colorect.
cancer.
C/I: Hypersens., lact., myelosuppress.
prior to 1st course, peripheral sens.
neuropath prior to 1st course, severe
impair. ren. funct.