Alkylating Agent (platinum analog)

5 Drugs classified under this drug class

Alkylating Agent (platinum analog). Cisplatin 1 mg/ml.
VIALS: 1 x 100 ml, 50 ml. See lit.
Palliative in add. to other modalities
in
tmt. metastat. testic. and ovar. cancer,
advanced bladder cancer.

Alkylating Agent (platinum analog). Carboplatin 10 mg/ml.
VIALS (Conc. for sol. for infus.): 1 x 5 ml,
15 ml, 45 ml, 60 ml. Dosage must be
ajust. individ. accord. to pt. med. cond.
Advanced ovar. carcinoma in initial tmt.
and secondary tmt. Metastatic small cell
carcinoma of the lung.
C/I: Severe renal impair. (CrCL< 20 ml/
min), severe myelosuppress., Hypersens.
to platinum compounds or mannitol,
pts with bleeding tumours, lact.

Alkylating Agent (platinum analog). Oxaliplatin 5 mg/ml.
SOLN (conc. for infus.): 10 ml, 20 ml, 40 ml. Adults only. Adjuv. setting: 85 mg/m2 I.V. every 2 wks for 12 cycles (6 mths). Metastat. colorect. cancer: 85 mg/m2 I.V. every 2 wks.
In comb. with fluorouracil and folic acid for adjuv. tmt. stage III (Duke’s C) colon cancer aft. complete resect. prim. tumor, metastat. colorect. cancer.

Alkylating Agent (platinum analog). Oxaliplatin 50, 100, 150 mg.
VIAL: 1 x 50 mg, 100 mg, 150 mg
(reconstitut. soln: 5 mg/ml oxaliplatin).
Adults only. Adjuv. setting: 85 mg/m²
I.V. Repeat every 2 wks. for 12 cycles (6
mths). Metastat. colorect. cancer: 85
mg/m2 I.V. Repeat every 2 wks. Adjust
dose accord. tolerability. Always
admin. bef. fluoropyramidines. See lit.
In comb. with 5-fluorouracil (5-FU) and
folinic acid for adjuv. tmt. stage III (Duke’s
C) colon cancer aft. complete resect.
primary tumor, tmt. metastat. colorect.
cancer.
C/I: Hypersens., lact., myelosuppress.
prior to 1st course, peripheral sens.
neuropath prior to 1st course, severe
impair. ren. funct.

Alkylating Agent (platinum analog). Oxaliplatin 5 mg/ml.
VIALS (conc. for sol. for infus.): 1 x 10 ml,
20 ml, 40 ml. For I.V. infus., adults only. See lit.
Adjuv. setting: Metastat. colorect.
cancer: 85 mg/m2 repeat. every 2 wks
for 12 cycles (6 mths). Admin. as a 2-6
hr I.V. infus. in 5% glucose sol. (see lit.).
Mainly used in comb. with cont. infus.
5-FU based regimens. Ren. impair:
Mild-mod: Init. normal recommend.
dose. Severe: No data. Hepat. impair:
No specific dose adjusts. test
performed during clin. develop.
Elderly: No specific dose adjusts.
Should always be admin. bef.
fluoropyramidines.
In comb. with 5-fluorouracil (5-FU) and
folinic acid (FA) for adjuv. tmt. stage III
(Duke’s C) colon cancer aft. complete
resect. prim. tumor; tmt. metastat.
colorect. cancer.
C/I: Hypersens., lact., periph. sens.
neuropathy with funct. impair. prior to
1st course; myelosuppress. prior to start.
1st course, severe impair. ren. funct.
(creatinine clear. < 30 ml/min).