Antifungal

2 Drugs classified under this therapeutic system

Antifungal. Anidulafungin 100 mg.
Vial. Pwder. for conc. for sol. for inf.. 1 X 100 mg
Adlts: A sgle 200 mg loading dose to be admin. on Day 1, then 100 mg daily thereafter. Duration of tmt to be based on the patient’s response. In gral, antifungal ther. should continue for at least 14 days after the last positive culture but no longer than 35 d.
Paed. pop.: A sgle loading dose of 3.0 mg/kg (not to exceed 200 mg) to be admin. on Day 1 then a daily dose of 1.5 mg/kg (not to exceed 100 mg) thereafter. Duration of tmt to be based on the patient’s response. In gral, antifungal ther. should continue for at least 14 days after the last positive culture.
Tmt of invasive candidiasis in adlts and paed. pts aged 1 month to < 18 years
C/I: Hypersens., incl to echinocandin class.

Imidazole Derivative Antifungal. Ketoconazole 200 mg.
TABS.:60. Initiat. dose  in adult.& adolesc. is 400-600 mg/d. taken orally in two or three divid. doses and this dose can be incr. rapidly to 800-1,200 mg/d in two or three divid. doses.
At tmt. initiat., 24-h urinary free cortisol should be controlled every few days/wks.
Adjust. of the posology
The dly. dose should be periodic. adjust. on an individ. basis with the aim to normalise urin. free cortisol and/or plasma cortisol levels.
A dose incr.of 200 mg/d. every 7- 28 d. may be consid. if urin. free cortisol and/or plasma cortisol levels are above the normal range, as long as the dose is tolerated by the pt.;
A mainten. dose from 400 mg/d.  to a max. dose of 1,200 mg/d. taken orally in 2 to 3 divided doses may be requir. to restore normal cortisol levels. the maint.  dose varied betwn. 600 mg/d. and 800 mg/d. See lit.
Indicated for the tmt. of endogenous Cushing’s syndr. in adult.& adolesc. above the age of 12 yrs.
C/I: Hypersens.
Hypersens. to any imidazole antifung. medication produc.
Acute or chron. hep. dis. and/or if pre-tmt. liver enzymes levels are above 2 times the upper limit of normal.
Preg.
Lact.
Pts. with  documented acquired QTc prolong.
Concom. ther. simvastatin, atorvastatin, lovastatin, eplerenone, methadone, disopyramide, quinidine, dronedarone, pimozide, sertindole, saquinavir (saquinavir/ritonavir 1000/100 mg bid), ranolazine, mizolastine, halofantrine, dabigatran, triazolam, oral midazolam, alprazolam.
Concom. ther. with ergot alkaloids (e.g. dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine).
Concomitant therapy with lurasidone, quetiapine, telithromycin  clarithromycin, felodipine, nisoldipine, colchicine,  irinotecan, everolimus, sirolimus.
Concom. ther. with vardenafil in men older than 75-yrs.
Concom. ther. with paritaprevir/ombitasvir (ritonavir).
Concom. ther, with fesoterodine and solifenacin in pts. with renal impair.
Concom. ther. with tolvaptan.