All the Therapeutic System Drugs
Antifungal. Anidulafungin 100mg. VIAL:1. A single 200 mg load. dose should be admin. on Day 1, follow. by 100 mg dly. thereafter. Durati.of tmt. should be based on the pt’s. clinic. response. In general, antifung. ther. should cont. for at least 14 d. after the last positi. culture.
Durat. of tmt. There are insuffic. data to support the 100 mg dose for longer than 35 d. of tmt.
For IV use only, must not be admin. as a bolus inj. See lit.
Tmt. of invas. candidiasis in adult Indications pts.
Hypersens. to other meds. products of the echinocandin class.
Imidazole Derivative Antifungal. Ketoconazole 200 mg. TABS.:60. Initiat. dose in adult.& adolesc. is 400-600 mg/d. taken orally in two or three divid. doses and this dose can be incr. rapidly to 800-1,200 mg/d in two or three divid. doses.
At tmt. initiat., 24-h urinary free cortisol should be controlled every few days/wks.
Adjust. of the posology
The dly. dose should be periodic. adjust. on an individ. basis with the aim to normalise urin. free cortisol and/or plasma cortisol levels.
A dose incr.of 200 mg/d. every 7- 28 d. may be consid. if urin. free cortisol and/or plasma cortisol levels are above the normal range, as long as the dose is tolerated by the pt.;
A mainten. dose from 400 mg/d. to a max. dose of 1,200 mg/d. taken orally in 2 to 3 divided doses may be requir. to restore normal cortisol levels. the maint. dose varied betwn. 600 mg/d. and 800 mg/d. See lit.
Indicated for the tmt. of endogenous Cushing’s syndr. in adult.& adolesc. above the age of 12 yrs.
Hypersens. to any imidazole antifung. medication produc.
Acute or chron. hep. dis. and/or if pre-tmt. liver enzymes levels are above 2 times the upper limit of normal.
Pts. with documented acquired QTc prolong.
Concom. ther. simvastatin, atorvastatin, lovastatin, eplerenone, methadone, disopyramide, quinidine, dronedarone, pimozide, sertindole, saquinavir (saquinavir/ritonavir 1000/100 mg bid), ranolazine, mizolastine, halofantrine, dabigatran, triazolam, oral midazolam, alprazolam.
Concom. ther. with ergot alkaloids (e.g. dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine).
Concomitant therapy with lurasidone, quetiapine, telithromycin clarithromycin, felodipine, nisoldipine, colchicine, irinotecan, everolimus, sirolimus.
Concom. ther. with vardenafil in men older than 75-yrs.
Concom. ther. with paritaprevir/ombitasvir (ritonavir).
Concom. ther, with fesoterodine and solifenacin in pts. with renal impair.
Concom. ther. with tolvaptan.