Drugs Disributed by Inovamed Ltd
Aromatase Inhibitor. Anastrozole 1 mg. F.C. TAB: 30. Not recommend. in child.
Adults, includ. elderly: 1 tab 1 x dly.
Mild/mod. ren. impair: No dose
change. Mild hepat. impair: No dose
change.
Tmt. advanced breast cancer in
postmenopaus. women. Efficacy not
demonstrat. in estrogen recept. neg. pts
unless with prev. +ive. clin. response to
tamoxifen; adjuv. tmt. postmenopaus.
women with hormone recept. +ive early
invas. breast cancer; adjuv. tmt. early
breast cancer in hormone recept. +ive
postmenopaus. women who have
received 2-3 yrs adjuv. tamoxifen.
C/I: Pre-menopaus. women; pregn.,
lactat., severe renal impair. (creatin.
clearance < 20 ml/min.); mod.-severe
hepat. dis; known hypersens., co-admin
of estrogen-contain. ther./tamoxifen
ther.
Anti-Androgen. Bicalutamide 150 mg. F.C. TABS: 30 x 50 mg, 150 mg. Swallow
whole with liq. Adult males (incl.
elderly): 50/150 mg 1 x dly at same
time, morn/even. Ren. impair., mild
hepat. impair: No dos. adjust necess.
See lit.
Advanced prostate cancer in comb. with
LHRH analog ther. or surg. castrat.
C/I: Hypersens., co-admin with
terfenadine, astemizole, cisapride.
Anti-Androgen. Bicalutamide 50 mg. F.C. TABS: 30 x 50 mg, 150 mg. Swallow
whole with liq. Adult males (incl.
elderly): 50/150 mg 1 x dly at same
time, morn/even. Ren. impair., mild
hepat. impair: No dos. adjust necess.
See lit.
Advanced prostate cancer in comb. with
LHRH analog ther. or surg. castrat.
C/I: Hypersens., co-admin with
terfenadine, astemizole, cisapride.
β1 Blocker. Bisoprolol Fumarate 2.5, 5, 10 mg. F.C. TABS.: 7, 10, 14, 20, 28, 30, 56, 60, 90,
500. Depend. on the dis. and the pt. cond.,
2.5 mg -10 mg×1/d. Max. recom. dose 20 mg×1/d.
2.5 mg tabs: Stable, chron., moder.- severe
HF. 5 mg , 10 mg tabs: Hypertens, CHD
(ang. pect.).
C/I: 2nd, 3rd degree AV block. Sinus
bradyc. Sick sinus syndr. Severe periph.
arter. dis. Printzmetal’s angina,
uncompens. card. fail. (except
carvedilol), cardiog. shock, hypotens.,
right ventr.fail. second. to pulmon.
hyperten., significant cardiomeg.
Untreat. phaeochromocytoma, metab.
acidosis. Non-cardiosel. β-block.
(nadolol, oxprenolol, penbutolol,
pindolol, propranolol, timolol) are also
generally contraind.in pts. with obstruct.
airways dis. or a history of
bronchospasm.
Antimetabolite. Capecitabine 500 mg. F.C. TABS.: 30, 60, 120. Dosage must be ajust. individ. accord. to pt. medical cond.
Adjuvant Colon Cancer: of pts. follow. surgery of stage III (Dukes stage C) colon cancer. Tmt. of pts. with advanced or metast. colorect. cancer. 1st line tmt. of advanced gastric cancer in comb. with
chemother. In comb. with docetaxel is indic. for the tmt. of pts. with metast. breast cancer after fail.of prior anthracyclinecontain. chemother. Capecitabine is also indicated for the tmt. of advanced or metast. breast cancer after fail. of standard ther. includ. a taxane unless therapy with a taxane is clinical. contraind.
C/I: Hypersens., history of severe and unexpected reac. to fluoropyrimidine ther., Hypersens to fluorouracil. In pts. with known DPD defic. Preg., lact. Sev. leucopenia, neutropenia, or thrombocytopenia. Sev. hep.impair. Sev. renal impair. (CrCl< 30 ml/min). Tmt. with sorivudine or its chem. related analogues, such as brivudine. If contraind. exist to any of the med. products in the comb.regimen, that med. product should not be used.
Anthracycline. Epirubicin HCl 2 mg/ml. VIALS (sol. for inject.): 5 x 5 ml, 10 ml, 25
ml, 50 ml, 100 ml. I.V./intravesical:
Adjust accord. indicat., age, gen. cond., card/hepat. funct., concurr.
chemother., blood counts. See lit.
Tmt. wide spectrum neoplast. dis., incl.
breast carc., lung carc. high doses, ovarian
carc., gastric carc., soft tissue sarcoma.
Intravesical admin. found benefic. tmt. fic.
bladder carc., prophylax. recurr. aft.
transurethral resect. I.V. admin tmt.
advanced bladder carc.
C/I: By I.V. route: Known hypersens.
Severe bone marrow depress. follow.
prev. chemother./ radiother. Pts already
treated with anthracyclines such as
doxorubicin/ daunorubicin up to
relevant max. cumulative dose. Acute
infects., existing inflamm. of buccal/GI
mucosa. Progress. heart fail., arrhythm.,
conduct. disords. with serious
hemodynam. effects, acute inflamm.
myocard. conds., unstable ang. pect.,
acute MI/within 6 mths, cardiomyopath.
By intravesical route: Tmt. of invasive
tumors penetrating bladder wall.