Vector

/ Unipharm

Hypertension: 80 mg, once a day. May increase to 160 mg, once a day.
Heart failure: Initial dosage is 40 mg, twice a day up to 160 mg twice a day.
See prescribing information for full details.

Hypertension, heart failure (NYHA class II-IV) in patients intolerant to angiotensin converting enzyme inhibitors. To improve survival following myocardial infarction in clinically stable patients with signs, symptoms or radiological evidence of left ventricular failure/dysfunction.

Hypersensitivity to components, pregnancy, lactation, severe hepatic impairment, biliary obstruction, cirrhosis.

Sodium and/or volume-depleted patients. Sodium and/or volume depletion should be corrected before starting treatment. In mild to moderately hepatically impaired patients, a lower dose is recommended, and 80 mg should not be exceeded. In patients with heart failure, concomitant use with an ACE inhibitor and a beta blocker is not recommended. In patients with bilateral or unilateral renal artery stenosis, monitoring is recommended as a safety measure. Caution when driving or operating machinery.
See prescribing information for full details.

In general, mild and transient in nature. Fatigue, syncope, diarrhea, liver function abnormalities, thrombocytopenia, arthralgia, myalgia, headache, dizziness, mild and transient taste disturbance, renal dysfunction and isolated cases of renal impairment, cough, epistaxis.
See prescribing information for full details.

Glibenclamide, potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium.