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  • Nuclease Reverse Transcriptase Inhibitor
    2 Drugs classified under this drug class


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    Epivir Oral Solution
    GSK
    RX
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    Epivir Oral Solution

    Nuclease Reverse Transcriptase Inhibitor. Lamivudine 10 mg/ml.
    ORAL SOL.: 240 ml x 10 mg/ml. Adult., adolesc., child. (wt. at least 25 kg): 300 mg dly. 150 mg (15 ml) ×2/d or 300 mg (30 ml) ×1/d.
    Child. (wt. <25 kg): Child. from 1 yr. of age: 0.5 mL/kg (5 mg/kg) ×2/d, or 1 mL/kg (10 mg/kg) once daily.
    Child. <3 mnths. of age- to 1 yr. of age: 0.5 mL/kg (5 mg/kg) ×2/d. If a twice dly. regimen is not feasible, a once dly. regimen (10 mg/kg/day) could be consid. It should be taken into account that data for the once dly. regimen are very limited in this populat.
    Child. <3 mnths. of age: The limited data available are insuffic. to propose specific dosage recomm. See lit.
    Antiretroviral combination tmt. of HIV
    infect.
    C/I: Hypersens.

    Epivir Tablets
    GSK
    RX
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    Epivir Tablets

    Nuclease Reverse Transcriptase Inhibitor. Lamivudine 150 mg, 300 mg.
    F.C. TABS: 60 x 150 mg, 30 x 300 mg.
    Adults, adolesc. & child. (weigh. at least 25 kg): 300 mg dly. This may be admin. as either 150 mg ×2/d or 300 mg ×1/d.
    The 300 mg tab. is only suitab.  for the once a day regimen.
    Child. (weigh. less than 25 kg): Dosing accord. to weight bands is recomm. for tabs.
    Child. wt. ≥ 20 kg to <25 kg: The recomm.  dose is 225 mg dly. This may be admin. as either 75 mg (1/2 tab. of a 150 mg tab.) taken in the morn. and 150 mg (one whole 150 mg tab.) taken in the eve., or 225 mg (one and a half 150 mg tabs.) taken once dly.
    Child. wt. 14 to < 20 kg: 150 mg dly.
    This may be admin. as 75 mg (one-half of a 150 mg tablet) taken twice dly., or 150 mg (one 150 mg tab.) taken once dly. See lit.
    Antiretroviral combination tmt. of HIV
    infect.
    C/I: Hypersens.

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