All the Drug Class Drugs
GnRH Antagonist. Cetrorelix (as acetate) 0.25 mg/vial. Powder and solv. for SC. inj. 0.25 mg/ vial . Once daily, first dose to be admin. under med. supervision.
Preven. of premat. ovul. in pts. undergoing a contr. ovarian stimul. for IVF.
C/I: Hypersens. to the act. subst. or any struct. analogues of GnRH, extrins. pept. hnes., mannitol.
• pregn. and lact.
• sev. renal impair
GnRH Antagonist. Degarelix (as Acetate) 80 mg, 120 mg. VIALS (pwdr. for sol. for inject.): 1 x 80
mg + 1 vial solv; 2 x 120 mg + 2 vials
solv. S.C. inject. into abdom. reg. over
18 yrs. See lit. Initial: 240 mg as 2 S.C.
injects (120 mg ea.), then 80 mg S.C. 1
x month.
Adult male pts. with advanced hormonedepend. prostate cancer.
C/I: Hypersens.
GnRH Antagonist. Ganirelix 0.25 mg / 0.5 ml. PRE-FILLED SYRINGE: 1, 5. To be
prescribed only by a specialist in tmt. of
infertil. Admin. S.C. in upper leg. Start at
day 2 or 3 of menses, 0.25 mg S.C. 1 x dly
on day 6 of FSH admin. See lit.
Prevent. prem. luteiniz. hormone (LH)
surges in women undergoing controlled
ovarian hyperstim. (COH) for assisted
reproduct. techniques (ART).
C/I: Hypersens., to compon., to
gonadotrophin-release. hormone
(GnRH) or any other GnRH analgoue,
mod- severe impaired ren. or hepat.
funct., pregn., lact.
GnRH Antagonist. Elagolix (as sodium) 150 mg, 200 mg. F.C. TABS: 28×150mg, 56×200mg. Init. tmt. with 150 mg×1/d, max. tmt. duration-24 mnths.
Consider initiat. tmt. with 200 mg×2/d max. tmt. duration- 6 mnths., with coexist. cond.- dyspareunia.
Init. tmt. with Elagolix 150 mg×1/d. Use of 200 mg×2/d is not recommended, max. tmt. duration- 6 mnths., with coexist. cond.- moder. hep. impair. (Child-Pugh Class B).
Hep. Impair.: No dosage adjust. of Elagolix is require. in women with mild hep. impair. (Child-Pugh A). Elagolix 150 mg×1/d is recomm. for women with moder. hep. impair. (Child-Pugh B) with the duration of tmt. limited to 6 mnths. Use of Elagolix 200 mg×2/d is not recommend. for women with moder. hep. impair. See lit.
Management of moder.–seve. pain assoc. with endometriosis.
C/I: With Hypersens. Preg. Women with known osteoporosis. Women with sev. hep. impair (Child-Pugh C). Concomitant use of strong organic anion transporting polypeptide (OATP) 1B1 inhibitors (e.g., cyclosporine and gemfibrozil).
IL-ELAG-200027-Sep. 2020
