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  • GnRH Antagonist
    3 Drugs classified under this drug class


    All the Drug Class Drugs

    Firmagon
    Ferring Pharmaceuticals
    RX
    partial basket chart
    Firmagon

    GnRH Antagonist. Degarelix (as Acetate) 80 mg, 120 mg.
    VIALS (pwdr. for sol. for inject.): 1 x 80
    mg + 1 vial solv; 2 x 120 mg + 2 vials
    solv. S.C. inject. into abdom. reg. over
    18 yrs. See lit. Initial: 240 mg as 2 S.C.
    injects (120 mg ea.), then 80 mg S.C. 1
    x month.
    Adult male pts. with advanced hormonedepend. prostate cancer.
    C/I: Hypersens.

    Orgalutran
    MSD
    RX
    partial basket chart
    Orgalutran

    GnRH Antagonist. Ganirelix 0.25 mg / 0.5 ml.
    PRE-FILLED SYRINGE: 1, 5. To be
    prescribed only by a specialist in tmt. of
    infertil. Admin. S.C. in upper leg. Start at
    day 2 or 3 of menses, 0.25 mg S.C. 1 x dly
    on day 6 of FSH admin. See lit.
    Prevent. prem. luteiniz. hormone (LH)
    surges in women undergoing controlled
    ovarian hyperstim. (COH) for assisted
    reproduct. techniques (ART).
    C/I: Hypersens., to compon., to
    gonadotrophin-release. hormone
    (GnRH) or any other GnRH analgoue,
    mod- severe impaired ren. or hepat.
    funct., pregn., lact.

    ORILISSA
    AbbVie
    RX
    not in the basket chart
    ORILISSA

    GnRH Antagonist. Elagolix (as sodium) 150 mg, 200 mg.
    F.C. TABS: 28×150mg, 56×200mg. Init. tmt. with 150 mg×1/d, max. tmt. duration-24 mnths.
    Consider initiat. tmt. with 200 mg×2/d max. tmt. duration- 6 mnths., with coexist. cond.- dyspareunia.
    Init. tmt. with Elagolix 150 mg×1/d. Use of 200 mg×2/d is not recommended, max. tmt. duration- 6 mnths., with coexist. cond.- moder. hep. impair. (Child-Pugh Class B).
    Hep. Impair.: No dosage adjust. of Elagolix is require. in women with mild hep. impair. (Child-Pugh A). Elagolix 150 mg×1/d is recomm. for women with moder. hep. impair. (Child-Pugh B) with the duration of tmt. limited to 6 mnths. Use of Elagolix 200 mg×2/d is not recommend. for women with moder. hep. impair. See lit.
    Management of moder.–seve. pain assoc. with endometriosis.
    C/I: With Hypersens. Preg. Women with known osteoporosis. Women with sev. hep. impair (Child-Pugh C). Concomitant use of strong organic anion transporting polypeptide (OATP) 1B1 inhibitors (e.g., cyclosporine and gemfibrozil).

    IL-ELAG-200027-Sep. 2020

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