All the Drug Class Drugs
Domapine Agonist. Apomorphine HCl 10 mg/ml. AMPS (sol. for inject): 5 x 2 ml, 5 ml. For
S.C. only. Establish pt on domperidone
20 mg 3 x dly for at least 2 days prior
to initiat. ther. Initiat. should be under
specialist vis. Determinat. thresh.
dose: Inject 1 mg (0.1 ml) S.C. dur.
hypokinet. or “off” period. Observe pt
over 30 mins for motor response. If no
response, give 2nd dose 2 mg (0.2 ml)
S.C., observe for 30 mins. Dose can be
incr. with at least a 40 min-interval
until a satisfact. motor response.
Establish. tmt: A single S.C. inject. into
lower abd. or outer thigh at 1st signs
of “off” episode. Observe pt for the
next hr. Precautions on contin. tmt./
cont. infus: See lit.
PEN FOR INJECT: 5 x 3 ml. For S.C. only.
Pts. select. tmt. should be able to
recognize onset of ‘off’ sympts. and
capable of inject. themselves or have a
respons. caregiver to inject them when
req. As per above.
Tmt. disabl. motor flucts. (“on-off”
phenomena) in Parkinson’s dis. which
persist despite individ. titrat. tmt. with
levodopa (with a periph. decarboxylase
inhibit.) and/or other dopamine
agonists.
C/I: Respir. depress., dementia, psychot.
dis., hepat. insuffic. Pts who have an ‘on’
response to levodopa that is marred by
severe dyskines./dyston. Known
hypersens. to apomorphine or any
excip. Child, adolesc. under 18 yrs. of
age.
Domapine Agonist. Cabergoline 0.5 mg. TABS: 2, 8. Take with meals. Dose: See
lit.
Tmt. dysfuncts., assoc. with
hyperprolactinem., incl. amenorrh.,
oligomenorrh., anovulat., galactorrh. In
pts. with prolactin-secret. pituitary
adenomas (micro/macro) idiopath.
hyperprolactinem., empty sella syndr.
with assoc. hyperprolactinem.
C/I: Hypersens., any ergot alkaloid,
uncontrolled hypertens.
Domapine Agonist. Cabergoline 0.5 mg. TABS: 8. 1 tab. wkly. in 1 or 2 doses. If necess. incr. grad. by 1 tab wkly at
mthly intervals. Maint: 1 mg wkly. with
ranges from 0.25 mg-2 mg. Up to 4.5
mg wkly. have been used.
TABS: 2. Inhibit. lact: Admin. during 1st
day (24 hrs.) post-partum: 1 mg (2 x 0.5
mg tabs) as single dose.
Suppress. estab. lact: 0.25 mg (1/2 0.5 mg tab) every 12 hrs. for 2 days (1 mg total dose).
Tmt. of hyperprolactinemic disord.
Tmt. of dysfunct. assoc. with hyperprolactinem., include. amenorrhea, oligomenorrhea, anovulat. and galactorrhea.
Indic. in pts. with prolactin-secret. pituitary adenoma. (micro-and macroprolactinomas), idiopathic hyperprolactinem., or empty sella syndr.with assoc. hyperprolactinemia. Inhibit. and suppress. of lact.
C/I: Hypersens. to cabergoline or ergot alkaloid.
Hist. of pulmon., pericard. and retroperitoneal fibrotic disord.
Pts. with hep. insuffic. and with toxaemia of preg.
Co-admin. with anti-psychotics or admin. to women with a history of puerperal psychosis.
Admin. for long-term tmt. See lit.
Domapine Agonist. Quinagolide HCl 0.025, 0.05 mg. TABS: 3 + 3 x 25 μg, 50 μg (starter pack). 25 μg/day for first 3 days, foll. by 50 μg/day for 3 days. From day 7: 75 μg/day. See lit.
2nd line tmt. hyperprolactinem.
(idiotpath./due to prolactin secret. micro/
macroadenoma) and clin. maninfests.
(galactorrh., oligomenrrh., infertil.,
reduced libido).
Domapine Agonist. Quinagolide HCl 0.075, 0.15 mg. TABS: 3 + 3 x 25 μg, 50 μg (starter pack);
30 x 75 μg, 150 μg. 25 μg/day for first 3
days, foll. by 50 μg/day for 3 days. From
day 7: 75 μg/day. See lit.
2nd line tmt. hyperprolactinem.
(idiotpath./due to prolactin secret. micro/
macroadenoma) and clin. manifests.
(galactorrh., oligomenrrh., infertil.,
reduced libido).
Domapine Agonist. Pramipexole Dihydrochloride Monohydrate 0.25, 1 mg. TABS: 30, 50, 90, 100 x 0.25 mg, 1 mg.
With/out food in 3 equal divid. doses.
Not recommend. below 18 yrs.
Parkinson’s dis: 0.375 mg dly, incr.
every 5-7 days. Max: 4.5 mg dly.
Discont: Taper at rate of 0.75 mg dly
until dly dose of 0.75 mg, then reduce
by 0.375 mg dly. Restless legs syndr:
0.125 mg 1 x dly, 2-3 hrs. bef. bedt. May
incr. every 4-7 days to max. 0.75 mg
dly. Ren. impair: See lit. Hepat. impair:
No dos. adjust. See lit.
Tmt. signs/sympts. idiopath. Parkinson’s
dis. May be used as monother./comb.
with levodopa; sympt. tmt. mod-severe
idiopath. Restless legs syndrome (0.25 mg).
C/I: Hypersens., lact. comb. with
antipsychot. drugs.
