All the Active Ingredient Drugs
Domapine Agonist. Apomorphine HCl 10 mg/ml. AMPS (sol. for inject): 5 x 2 ml, 5 ml. For
S.C. only. Establish pt on domperidone
20 mg 3 x dly for at least 2 days prior
to initiat. ther. Initiat. should be under
specialist vis. Determinat. thresh.
dose: Inject 1 mg (0.1 ml) S.C. dur.
hypokinet. or “off” period. Observe pt
over 30 mins for motor response. If no
response, give 2nd dose 2 mg (0.2 ml)
S.C., observe for 30 mins. Dose can be
incr. with at least a 40 min-interval
until a satisfact. motor response.
Establish. tmt: A single S.C. inject. into
lower abd. or outer thigh at 1st signs
of “off” episode. Observe pt for the
next hr. Precautions on contin. tmt./
cont. infus: See lit.
PEN FOR INJECT: 5 x 3 ml. For S.C. only.
Pts. select. tmt. should be able to
recognize onset of ‘off’ sympts. and
capable of inject. themselves or have a
respons. caregiver to inject them when
req. As per above.
Tmt. disabl. motor flucts. (“on-off”
phenomena) in Parkinson’s dis. which
persist despite individ. titrat. tmt. with
levodopa (with a periph. decarboxylase
inhibit.) and/or other dopamine
agonists.
C/I: Respir. depress., dementia, psychot.
dis., hepat. insuffic. Pts who have an ‘on’
response to levodopa that is marred by
severe dyskines./dyston. Known
hypersens. to apomorphine or any
excip. Child, adolesc. under 18 yrs. of
age.
