All the Active Ingredient Drugs
Antimetabolite. Capecitabine 500 mg. F.C. TABS.: 30, 60, 120. Dosage must be ajust. individ. accord. to pt. medical cond.
Adjuvant Colon Cancer: of pts. follow. surgery of stage III (Dukes stage C) colon cancer. Tmt. of pts. with advanced or metast. colorect. cancer. 1st line tmt. of advanced gastric cancer in comb. with
chemother. In comb. with docetaxel is indic. for the tmt. of pts. with metast. breast cancer after fail.of prior anthracyclinecontain. chemother. Capecitabine is also indicated for the tmt. of advanced or metast. breast cancer after fail. of standard ther. includ. a taxane unless therapy with a taxane is clinical. contraind.
C/I: Hypersens., history of severe and unexpected reac. to fluoropyrimidine ther., Hypersens to fluorouracil. In pts. with known DPD defic. Preg., lact. Sev. leucopenia, neutropenia, or thrombocytopenia. Sev. hep.impair. Sev. renal impair. (CrCl< 30 ml/min). Tmt. with sorivudine or its chem. related analogues, such as brivudine. If contraind. exist to any of the med. products in the comb.regimen, that med. product should not be used.
Antimetabolite (pyrimidine analog). Capecitabine 500 mg. TABS.: 120. Dosage should be ajust. individ.
Standard dose: The dosage is determ. based on a measure. called body surf. area.
The standard dose for adult. is 1250 mg per m2 of bdy. surf. area, taken twice a day (morn. & eve.). See lit.
Adjuv. colon canc.: for the adjuv. tmt. of pts. follow. surg. of stage III (Dukes stage C) colon canc.
Colorect. canc.: for the tmt. of pts. with advance. or metastat. colorect. canc.
Advanc. gastr. canc.: for 1st line tmt. of advance. gastr. canc. in comb. with chemother.
Breast canc. comb. ther.: in comb. with docetaxel is indicated for the tmt. of pts. with metastat. breast canc. after fail. of prior anthracycline-contain. chemother..
Breast canc. monother.: indic. for the tmt. of advance. or metastat. breast canc. after fail. of standard ther. includ. a taxane unless ther. with a taxane is clinical. contraindic.
C/I: History of sev. and unexpect. react. to fluoropyrimidine ther.
Hypersens. to capecitabine or to any of the excipients, or fluorouracil.
In pts. with known dihydropyrimidine dehydrogenase (DPD) defic.
During pregn. / lact.
Pts. with severe leukopenia, neutropen., or thrombocytopen.
Pts. with sev. hep. impair.
Pts. with sev. renal impair. (CrCl <30 ml/min).
Tmt. with sorivudine or its chemic. related analog., such as brivudine If contraindic. exist to any of the med. products in the comb. regimen, that med. product should not be used.
Pyrimidine Analogues. Capecitabine 150 mg, 500 mg. TABS: Capecitabine 150×60,
500mg×120.
Dosage must be ajust. individ. accord.
to the pt. med. cond.
Adjuv. colon cancer foll. surg. of stage III
(Duke’s stage C) colon cancer. Metastatic breast cancer in comb. with docetaxel aft.
fail of prior anthracycline-cont.
chemotherapy, as monother. advanced or
metastat. breast cancer aft. fail. standard
ther. incl. a taxane, unless ther. with a
taxane is clinic. contraindicat. Advanced
or metastat. colorectal cancer. First line
tmt. advanced gastric cancer in comb.
with chemother.
C/I: Hist. of severe, unexpec. react. to
fluoropyrimidine ther.; Hypersens. to
capecitabine or to fluorouracil; Pts. with
known (DPD) defic.; Preg.; lact.; Pts. with
sev. leukopenia, neutropenia, or
thrombocytopenia; sev. hep. impair.; Pts.
with severe renal impair. (CrCl ≤ 30 ml/
min); Tmt. with sorivudine or its chemic.
related analog. , (e.g. brivudine); If
contraind. exist to any of the med.
products in the comb. regimen, that
med. product should not be used.
