Casodex 150 mg

/ Astra Zeneca

Adult males including the elderly: one tablet (50 mg) once a day.
Treatment with Casodex should be started at least 3 days before commencing treatment with an LHRH analogue, or at the same time as surgical castration.
Children: Casodex is contraindicated in children.
Renal impairment: no dosage adjustment is necessary for patients with renal impairment.
Hepatic impairment: no dosage adjustment is necessary for patients with mild hepatic impairment. Increased accumulation may occur in patients with moderate to severe hepatic impairment.

Treatment of advanced prostate cancer in combination with LHRH analogue therapy or surgical castration.

Hypersensitivity, women and children, co-administration of terfenadine, astemizole or cisapride.

See prescribing information for full details.

See prescribing information for full details.

Cimetidine, ketoconazole, oral anticoagulants.

Casodex is contra-indicated in females and must not be given to pregnant women or nursing mothers.

There is no human experience of overdosage. There is no specific antidote; treatment should be symptomatic. Dialysis may not be helpful, since Casodex is highly protein bound and is not recovered unchanged in the urine. General supportive care, including frequent monitoring of vital signs, is indicated.