All the Therapeutic System Drugs
Ocular Antineovascularisation Agent. Aflibercept 40 mg/ml. VIAL (Sol. for Intravitreal inj.): 40 mg/ml.
Wet AMD: Initiat. tmt. 1 inj. per month
for 3 consec. doses, follow.by 1 inj.
every 2 mths. After the 1st 12 mths. of
tmt. may exten. tmt. interv. based on
vis. and anatom. outcomes. Monitor.
Sched. should be determin. by physic.
Macu. Oedem. due to CRVO: Initiat.
tmt. 1 inj. per month, follow. by 1 inj.
monthly. Diabetic Macular Oedema:
Initiat. tmt. 1 inj. per month for 5
consec. doses, follow. by 1 inj. every 2
mths. After the 1st 12 mths. of tmt. may
exten. tmt. interv. based on vis. and
Tmt. of neovasc. (wet) AMD. Tmt. of visual
impair. due to macular edem. second. to
branch RVO or central RVO. Tmt. of visual
impair. due to DME in adult.
C/I: Hypersens.; Act. or suspect. ocular or
perioc. infec.; Act. severe intraoc. inflam.
Anti-VEFG, Monoclonal Antibody. Ranibizumab 10 mg/ml. VIAL: 1 x 0.23 ml.
PFS: 1 x 0.165 ml. Initial: 0.5 mg given as a single intravitreal inj. This correspond. to an inj. volume of 0.05 ml. The interval between two doses inj. into the same eye should not be shorter than 1 m. See lit.
Preterm infants: 0.2 mg given as an intravitreal inj. This correspond. to an inj. volume of 0.02 ml. In preterm infants tmt. of ROP is initiat. with a single inj. per eye and may be given bilaterally on the same day. In total, up to three inj. per eye may be admin. within 6 mnths. of tmt. init. if there are signs of dis. activity.
The tmt. of pts. with neovascular (wet) age-related macular degenerat. (AMD).
The tmt. of adult pts. with visual impair. due to diabet. macular edema (DME).
The tmt. of visual impair. due to macular edema second. to retinal vein occlus. (RVO).
The tmt. of visual impair. due to choroidal neovascularization (CNV) second. to pathologic myopia (PM).
Indicated in preterm infants for: Tmt. of retinopathy of prematurity (ROP) with zone I (stage 1+, 2+, 3 or 3+), zone II (stage 3+) or AP-ROP (aggressive posterior ROP) dis.
C/I: Hypersens., Active/suspect. oc./perioc. infects., Severe intraoc. inflamm.