Oflox

/ AbbVie

Adults only: One to two drops in the affected eye(s) three or four times daily. The length of treatment should not exceed 10 days without an ophthalmic review.

OFLOX is indicated for the topical treatment of external ocular infections caused by ofloxacin-sensitive organisms.

OFLOX is contra-indicated in individuals who have shown hypersensitivity to ofloxacin, any of its excipients, or any other quinolones.
OFLOX is not recommended for use in children or adolescents before epiphyseal closures.
OFLOX should not be used during pregnancy or in women at risk of pregnancy, nor during lactation.

See prescribing information for full details.

Common: Eye irritation, Ocular discomfort.
See prescribing information for full details.

It has been shown that the systemic administration of some quinolones inhibits the metabolic clearance of caffeine and theophylline. Drug interaction studies conducted with systemic ofloxacin have demonstrated that metabolic clearance of caffeine and theophylline are not significantly affected by ofloxacin.
Although there have been reports of an increased prevalence of CNS toxicity with systemic dosing of fluoroquinolones when used concomitantly with systemic nonsteroidal anti-inflammatory drugs (NSAIDs), this has not been reported with the concomitant systemic use of NSAIDs and ofloxacin.
Mineral antacids used simultaneously may effect systemic absorption. Concomitant use of systemic quinolones with some phenylproprionic acid derived non-steroidal anti-inflammatory drugs may lead to toxicity possibly because of renal effects.
A study of concurrent administration with a coumarin anticoagulant showed no
interaction.
OFLOX, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong the QT interval (e.g. Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics).

Pregnancy: There have been no adequate and well-controlled studies performed in pregnant women. Since systemic quinolones have been shown to cause arthropathy in immature animals, it is recommended that OFLOX should not be used in pregnant women.
Lactation: Because ofloxacin and other quinolones taken systemically are excreted in breast milk and there is potential for harm to nursing infants, OFLOX
should not be used during lactation.

No case of overdose has been reported.
In the event of a topical overdose, flush the eye with water.
In the event of an overdose, symptomatic treatment should be implemented. ECG monitoring should be undertaken, because of the possibility of QT interval prolongation.

Shelf Life: 2 years, unopened. Discard unused contents 28 days after opening the bottle.
Storage: Do not store above 25ºC.