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    / Unipharm


    Active Ingredient

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Coated Tablets

    30 X 100 mg

    full basket chart 1445 14072

    Related information


    Dosage

    Hypertension: The usual starting dosage is generally 100 mg per day. The dosage may be increased to 200 mg per day as a single daily dose or in divided doses.
    Angina pectoris: 50-100 mg two or three times a day.
    Heart rhythem disturbances: 50 mg two or three times a day. The dosage may be increased to 300 mg per day, in divided doses.
    Heart attack: 50 mg every 6 hours. The recommended maintenance dose is 200 mg per day in divided doses.
    Prevention of migraines: 100-200 mg in divided doses (morning and evening).
    Children: This medicine is not intended for children.
    Liver or kidney function disorders: It may be neccessary to adjust the dosage.
    See prescribing information for full details.


    Indications

    Hypertension, angina pectoris, prophylaxis for myocardial reinfarction, reduce cardiovascular mortality in hemodynamic patients with acute myocardial infarction, prophylaxis of migraine syndromes, prophylaxis of paroxysmal tachycardia, prior to cardiac catheterisation.


    Contra-Indications

    2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, severe peripheral arterial disease, Printzmetal’s angina, uncompensated cardiac failure (except carvedilol), cardiogenic shock, hypotension, right ventricular failure secondary to pulmonary hypertension, significant cardiomegaly, untreated phaeochromocytoma, metabolic acidosis. Non-cardioselective β-blockers (nadolol, oxprenolol, penbutolol, pindolol, propranolol, timolol) are also generally contraindicated in patients with obstructive airways disease or a history of bronchospasm.


    Special Precautions

    Poor cardiac reserve should be controlled with digitalis and diuretics. History of bronchospasm (cardioselective β-blockers e.g. acebutolol, atenolol, betaxolol, bisoprolol, celiprolol, metoprolol, nebivolol usually have a lesser effect on airways resistance than the non-selective type but their use should also be avoided in patients with wheezing or obstructive airway disease unless there are compelling clinical reasons). Diabetes. Asthenic symptoms. Cerebrovascular insufficiency. Atopy. Renal or hepatic impairment, thyrotoxic crisis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy, lactation. Withdraw gradually.


    Side Effects

    Cold extremities, CNS and sleep disturbances (particularly with the more lipophilic drugs), bradycardia (less with carvedilol, pindolol), exertional tiredness, bronchospasm, heart failure, hypotension, GI upset, alopecia, thrombocytopenia. Withdraw gradually in unexplained dry eyes or skin rash.


    Drug interactions

    Verapamil, diltiazem, class I antiarrhythmics, amiodarone, cardiac depressant anesthetics, cardiac glycosides. Oral hypoglycemics, insulin, reserpine, ergot alkaloids. Cimetidien (with labetalol and propranolol only), indomethacin (possibly other NSAIDs), clonidine. Thyroxine, liver enzyme inducers (e.g. rifampicin, barbiturates), β-agonists, direct and indirect sympathomimetic amines, fluvoxamine, phenothiazines, propafenone.


    Manufacturer
    Trima Israel Pharmaceutical Products Maabarot Ltd. Israel
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