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Adults: 2 drops into the ear 3-4 times daily.
Children: 1-2 drops into the ear 3-4 times daily.
Inflammatory conditions, superficial bacterial infections of exterior auditory canal.
Known hypersensitivity. In fungal infections, tuberculosis of the skin, vaccinia, varicella, and herpes simplex. Should not be applied in the external auditory canal of patients with perforated eardrum.
Ototoxicity and nephrotoxicity have been reported with the topical use of neomycin. May be increased if the patient is being concurrently treated with an aminoglycoside antibiotic. Pregnancy and lactation. When using neomycin-containing preparations to control secondary infection in chronic dermatoses, such as chronic otitis externa or stasis dermatitis, it should be borne in mind that the skin is more liable to become sensitive to other substances, including neomycin. If extensive areas are treated or if the occlusive technique is used, the possibility exists of increased systemic absorption. Prolonged use may result in an overgrowth of non-susceptible fungi.
Stinging and burning may occur if the preparation gains access to the middle ear. Signs of a sensitivity reaction to neomycin may also appear, usually in the form of a low-grade reddening with swelling, dry scaling or itching, or simply as a failure to heal. During long-term use of neomycin-containing preparations, periodic examination for such signs is recommended. Allergic cross-reactions.
Phenytoin, barbiturates, carbamazepine, aminoglutethimide, rifampicin. Thiazide and loop diuretics, cardiac glycosides, acetazolamide. Oral hypoglycemics, insulin, antihypertensives, anabolic steroids, ophthalmic idoxuridine. NSAIDs, aspirin, other salicylates, coumarin anticoagulants, vaccines, estrogens.