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  • Phosphodiesterase-5 Enzyme Inhibitor
    7 Drugs classified under this drug class


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    Cialis
    Eli Lilly
    RX
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    Cialis

    Phosphodiesterase-5 Enzyme Inhibitor. Tadalafil 2.5, 5, 10, 20 mg.
    F.C. TABS: 4 x 10 mg; 4, 8 x 20
    mg. On-demand: 10 mg or 20 mg,
    depend. response, 30 mins. - 12 hrs
    bef. Sexual activity. Effic. may persist
    for up to 36 hrs. Max: 1 dose dly, but
    dly use not recommend. Child: Under
    18 yrs: Not recommend.
    F.C. TABS: 28 x 2.5 mg, 5 mg. Onceaday:
    For men who anticipate freq. use
    (min. 2 x wkly): 2.5 mg/5 mg 1 x dly,
    depend. on individ. tolerabil. Reassess period. See lit.
    Treatment of erectile dysfunction
    (ED) in adult men. Also indicated for the
    treatment of the signs and symptoms of
    benign prostatic hyperplasia (BPH), also
    indicated for the treatment of ED and the
    signs and symptoms of BPH (ED/BPH).
    CIALIS is not indicated for use by women.
    C/I: Co-adminis. nitrates. Card.dis. I,Uns.
    ang. uncont. Arrhythmias,
    hypotens. Uncontr. Hypertens. Use by
    women, see lit.

    Levitra
    Bayer
    RX
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    Levitra

    Phosphodiesterase-5 Enzyme Inhibitor. Vardenafil (as HCl) 5 mg, 10 mg, 20 mg.
    TABS: 2, 4 x 5 mg, 10 mg; 8 x 20 mg.
    Recommend. start. dose: 10 mg 25-60 mins. bef. intercourse. May incr. to 20 mg or decr. to 5 mg. Max: 20 mg/day.
    Max: 1 x dly. Over 65 yrs: Initial: 5 mg.
    Tmt. of erectile dysfunct. In order for the drug to be effective, sexual stimul. is required. Not indicated for use by women.
    C/I: Hypersens. Co-admin. with nitrates, nitric oxide donors (e.g. as amyl nitrite). Pts. who have loss of vision in one eye because of non-arteritic anter. ischem. optic neuropathy (NAION), regardless of whether this episode was in connect. or not with prev. phosphodiesterase 5 (PDE5) inhib.
    Meds. products for the tmt. of erectile dysfunct. should general. not be used in men for whom sex. activ. is inadvis. (e.g. pts. with sev. cardiovasc. disord. such as unstab. angina or sev. card. fail. [NYHA III or IV]).
    Severe hep. impair. (Child-Pugh C), end stage ren. dis. requir. dialys., hypotens. (BP 90/50 mmHg), Recent hist. of stroke or MI (within the last 6 mnths.), unstab. ang. and known hered. retin. degenerate. disord. such as retinit. pigmentosa.
    Concom. use with the potent CYP3A4 inhib. ketoconazole & itraconazole (oral form) is contraind. in men older than 75 yrs.
    Concom. use with HIV protease inhib. such as ritonavir & indinavir. Co-admin. of PDE5 inhib., with guanylate cyclase stimulat., (e.g. riociguat).

    Levitra 10 mg Orodispersible Tablets
    Bayer
    RX
    partial basket chart
    Levitra 10 mg Orodispersible Tablets

    Phosphodiesterase-5 Enzyme Inhibitor. Vardenafil 10 mg.
    ORODISPERSIBLE TABS: 4. Recommend. dose: 1 orodisp. tab. 25-60 mins. bef. intercourse. Max: 1 x dly (with/out food).
    Tmt. of erectile dysfunct. In order for the drug to be effective, sexual stimul. is required. Not indicated for use by women.
    C/I: Hypersens. Co-admin. with nitrates, nitric oxide donors (e.g. as amyl nitrite). Pts. who have loss of vision in one eye because of non-arteritic anter. ischem. optic neuropathy (NAION), regardless of whether this episode was in connect. or not with prev. phosphodiesterase 5 (PDE5) inhib.
    Meds. products for the tmt. of erectile dysfunct. should general. not be used in men for whom sex. activ. is inadvis. (e.g. pts. with sev. cardiovasc. disord. such as unstab. angina or sev. card. fail. [NYHA III or IV]).
    Severe hep. impair. (Child-Pugh C), end stage ren. dis. requir. dialys., hypotens. (BP 90/50 mmHg), Recent hist. of stroke or MI (within the last 6 mnths.), unstab. ang. and known hered. retin. degenerate. disord. such as retinit. pigmentosa.
    Concom. use with the potent CYP3A4 inhib. ketoconazole & itraconazole (oral form) is contraind. in men older than 75 yrs.
    Concom. use with HIV protease inhib. such as ritonavir & indinavir.
    Co-admin. of PDE5 inhib., with guanylate cyclase stimulat., (e.g. riociguat).

    Sildenafil Teva
    Abic
    RX
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    Sildenafil Teva

    Phosphodiesterase-5 Enzyme Inhibitor. Sildenafil 25, 50, 100 mg.
    F.C. TABS.: 4, 8 x 50 mg, 100 mg.
    To be taken once dly. 50 mg as needed
    approx. 1 h bef. sexual act.; may be
    incr. to 100 mg or decreas. to 25 mg.
    Max.:100 mg. May be taken before or
    after meal.
    Impair. renal funct.: mild-mod.: no
    dosage adjust. req.; Sev. renal impair.:
    25 mg should be consid. Impair. hepatic
    funct.: A dose of 25 mg should be
    consid.
    Elderly: Dosage adjust. is required.
    Tmt. of erectile dysfunct.
    C/I: Known hypersens. to product; pts.
    concur. using nitric oxide donors (such
    as amyl nitrite), organic nitrates, or
    organic nitrites in any form either
    regularly or intermittently; under 18
    years; sev. cardiovascular or sev. liver
    disease; recent history of MI ,stroke, or
    pts. who suffer from hypotension; pts.
    who have loss of vision in one eye
    because of non-arteritic anterior
    ischemic optic neuropathy (NAION);
    hereditary degener. retinal dis. such as
    retinitis pigmentosa; not intended to be
    used in women.

    Tadalis Teva
    Teva
    RX
    partial basket chart
    Tadalis Teva

    Phosphodiesterase-5 Enzyme Inhibitor. Tadalafil 20 mg.
    TABS.: 20mg × 1,4,8.
    1  tab., at least 30 min.  prior to sexual contact. Not more than 1 tab./ d. May  be taken at any time during the day. The effect may last up to 36 hrs. Not for daily use.
    Tmt. of erectile  dysfunct.  in adult men.
    C/I: Hypersens.. Concom. use with nitrates. Pts. with  MI within the last 90 d, unstab. ang. pect., hypertens. or uncontrol. arrhyth., hypotens. (below 90/50) or follow. a stroke that occur. in the past 6 mnths. Present/ prev.   vision loss as a result of a med.  condit.  called NAION. Concom. use with guanylate cyclase stimulator group (e.g., riociguat, for the tmt. of pulmon. hypertens.), since it can cause symptomat.  hypotens.

    Tarim
    Unipharm
    RX
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    Tarim

    Phosphodiesterase-5 Enzyme Inhibitor. Sildenafil (as citrate) 50, 100 mg.
    F.C. TABS: 4, 8 x 50 mg, 100 mg.
    50 mg 1 hr. bef. sex. intercourse. May
    incr. to 100 mg or decr. to 25 mg. Max:
    100 mg/day. Over 65 yrs: Initial: 25 mg.
    Erectile dysfunct.

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