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    2 Drugs classified under this drug class


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    Entresto
    Novartis
    RX
    partial basket chart
    Multiple ingredients
    Entresto

    Angiotensin II Antagonist, Other Combinations. Sacubitril 24, 49, 97 mg, Valsartan (as sodium salt complex) 26, 51, 103 mg.
    F.C. TABS: 28×50 mg, 56×100 mg, 56×200 mg. Init. dose: 1 tab (100 mg)×2/d, The dose should be doubled (in certain situation.) after 2-4 wks. to the target maint. dose of 1 tab. of 200 mg twice dly., as tolerated by the pt. See lit.
    Tmt. of heart fail. (NYHA class II-IV) in pts. with syst. dysfunc. This formulation has been shown to reduce the rate of cardiovasc. death and heart fail. hospitalis. compared to ACE inhib. therapy.
    C/I: Hypersens. Concom. use with ACE inhib. , ust not be admin. until 36 hrs. after discount. ACE inhib. ther. Known hist. of angioed.related to prev.ACE inhib. or ARB therapy. Hered. or idiopath. angioed. Concom. use with aliskiren-contain. med. products in pts. with diabetes mell. or in pts. with renal impair. (eGFR <60 ml/min/1.73 m2). Severe hep. impair., biliary cirrhosis and cholestasis. 2nd, 3rd trimes. of preg. Pts. with serum K+ level >5.4 mmol/l or with SBP <100 mmHg.

    Sector
    Unipharm
    RX
    partial basket chart
    Multiple ingredients
    Sector

    Angiotensin II Antagonist, Other Combinations. Sacubitril 24 mg, 49 mg, 97mg, Valsartan 26 mg, 51 mg, 103 mg.
    FC Tab.28 x50mg/ 56X100 mg/56X200 mg
    Start. dosage is gen. 50 mg or 100 mg twice/d. Target dosage is gen. 200 mg twice/d. See lit.
    Tmt. of heart fail. (NYHA class II-IV) in pts. with systol. dysfunct..
    This med. prod. has been shown to red. the rate of CV death and HF hosp. compared to angiotensin converting enzyme (ACE) inhib. ther.

    C/I:
      hypersens/Concomit. use with ACE inhib. Wait 36 hs. after taking last ACEI dose before starting tmt. with this med. prod.
    / Known hist. of angioedema rel. to ACE inhib. or an angiotensin receptor blocker (ARB) ther., hered. or unknown cause.
    / Concom. use with aliskiren-containing med. prod. in pts. with diabetes mellitus or with renal impaim.
    / Severe liver dis.
    /Second and third trim. of pregn.

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