All the Drug Class Drugs
Angiotensin II Antagonist, Other Combinations. Sacubitril 24, 49, 97 mg, Valsartan (as sodium salt complex) 26, 51, 103 mg. F.C. TABS: 28×50 mg, 56×100 mg, 56×200 mg. Init. dose: 1 tab (100 mg)×2/d, The dose should be doubled (in certain situation.) after 2-4 wks. to the target maint. dose of 1 tab. of 200 mg twice dly., as tolerated by the pt. See lit.
Tmt. of heart fail. (NYHA class II-IV) in pts. with syst. dysfunc. This formulation has been shown to reduce the rate of cardiovasc. death and heart fail. hospitalis. compared to ACE inhib. therapy.
C/I: Hypersens. Concom. use with ACE inhib. , ust not be admin. until 36 hrs. after discount. ACE inhib. ther. Known hist. of angioed.related to prev.ACE inhib. or ARB therapy. Hered. or idiopath. angioed. Concom. use with aliskiren-contain. med. products in pts. with diabetes mell. or in pts. with renal impair. (eGFR <60 ml/min/1.73 m2). Severe hep. impair., biliary cirrhosis and cholestasis. 2nd, 3rd trimes. of preg. Pts. with serum K+ level >5.4 mmol/l or with SBP <100 mmHg.
Angiotensin II Antagonist, Other Combinations. Sacubitril 24 mg, 49 mg, 97mg, Valsartan 26 mg, 51 mg, 103 mg. FC Tab.28 x50mg/ 56X100 mg/56X200 mg
Start. dosage is gen. 50 mg or 100 mg twice/d. Target dosage is gen. 200 mg twice/d. See lit.
Tmt. of heart fail. (NYHA class II-IV) in pts. with systol. dysfunct..
This med. prod. has been shown to red. the rate of CV death and HF hosp. compared to angiotensin converting enzyme (ACE) inhib. ther.
C/I: hypersens/Concomit. use with ACE inhib. Wait 36 hs. after taking last ACEI dose before starting tmt. with this med. prod.
/ Known hist. of angioedema rel. to ACE inhib. or an angiotensin receptor blocker (ARB) ther., hered. or unknown cause.
/ Concom. use with aliskiren-containing med. prod. in pts. with diabetes mellitus or with renal impaim.
/ Severe liver dis.
/Second and third trim. of pregn.