All the Drug Class Drugs
Opioid Analgesic. Fentanyl 67, 133, 267, 400, 533, 800 mcg. SUB LING. TABS.:30× 67, 133, 267, 400, 533, 800 mcg. Should be admin. direct.
under the tongue at the deepest part. All pts. must start ther.with a single 133
mcg SG tab. If adequate analgesia is not obtained within 15-30 min. of admin.
of a single tablet, a supplem. (second) 133 mcg tab. may be admin. If tmt. of a
breakthrough pain episode requires more than one dosage unit, an incr. in dose
to the next higher available strength should be consid. Dose escalation should
cont. in a stepwise manner until adequate analgesia is achieved. The dose
strength for the supplement. (2 nd ) tab. should be increased from 133- 267 mcg at
dose of 533 mcg. This is illustrated in the schedule below. No more than two (2)
tabs. should be admin. for a single episode of breakthrough pain during this
titrat. phase. See lit.
Tmt. of breakthrough pain in adult. with cancer who are already receiv. maintenan.
opioid ther. for chron. cancer pain.
C/I: Hypersens. Pts. without mainten. opioid ther. as there is an incr. risk of respirat. depress. Simultan. use of MAO inhib., or within 2 wks. after the cessation of the use of MAO inhib.
Severe respirat. depress. or severe obstruct.lung condit. Tmt. of acute pain other than breakthrough pain.
Opioid Analgesic. Fentanyl 12.5, 25, 50, 75, 100 mcg/hr. TRANSDERMAL PATCHES: 5x12.5µg/hr. (2.1mg/patch), 5x25µg/hr. (4.2mg/patch), 5x50µg/hr. (8.4mg/patch), 5x75µg/hr. (12.6mg/patch), 5x100µg/hr. (16.8mg/patch).
Dosage must be ajust. individ. accord. pt. condit.
Managem. of chron. pain and intractab. pain requir.opioid analgesia. The drug should only be used in pts. who are already receiv. opioid ther., who have demonstrate. opioid tolerance.
C/I: Hypersens. Pts. who did not use an opioid analgesic in the past. Short period pain (e.g., after surgery). Pts. with not chron./ persist. pain. Mild/moder. pain relief. Pts. with sev. breath. problems. Pts. with severe impair. of the CNS funct.(e.g., brain damage). During tmt. with MAO inhib., or within a minim. of 2 wks. of discont. those drugs. Lact. Child. under 2 yrs. of age.
Opioid Analgesic. Tramadol HCl 100 mg. AMPOUL.:1.
Adult.: A single d. of 50 mg/100 mg 4-6 hourl. IV must be given slowly over 2-3 min. For sev. (postoperat.) pain, admin. an init. bolus of 100 mg during the 60 min. follow. the init. bolus, further doses of 50 mg may be given every 10- 20 min., up to a total dose of 250 mg includ. the initial bolus. Subseq. doses should be 50/ 100 mg admin. every 4-6 hrs. A total daily dose of 400 mg should not be exceed. Except in special clinic. circumstances. Child. aged 1- 14 yrs. receive 1-2 mg /kg bdy. wt. as a single dose. For dosage for other populat. see lit.
Moderate severe to severe pain.
C/I: Hypersens. Acute intox. with hypnot. Central. Act. analgesics, opioids, psychotropic drugs or alcohol. Pts. who are receiving MAO inhib. or within 2 wks. of their withdrawal, with other opioids analges.. Epilepsy, not adequat. control. by tmt.