All the Active Ingredient Drugs
Opioid. Fentanyl (as Citrate) 100, 200, 300, 400, 600, 800 mcg. SUBLING. TABS: 10, 30 x 100 μg, 200 μg,
300 μg , 400 μg, 600 μg, 800 μg.
Initial: 100 μg. subling., not be
swallowed, chewed oe sucked. Titr.
upwards as necess. See lit.
Manag. of breakthr. pain in adult pts using
opioid ther. for chronic cancer pain.
Breakthr. pain is a transient exacerb. of
otherwise control. chronic background
C/I: Hypersens.; Opioid-naïve pts due to
the risk of life-threat. resp. depress.;
Sev. resp. depress. or sev. obstr. lung
cond.; acute or post-oper. pain, incl.
headache/migraine, dental pain, or use in
Opioid. Fentanyl (as citrate) 200, 400, 600, 800, 1200, 1600 mcg/dose. COMPRESSED TAB. ON HANDLE
(lozenge): 30. Initial: 200 μg. To supply
only 6 x 200 μg and to use all units bef. incr. to higher dose. See lit. Unit to be
sucked, not chewed over 15 mins.
Discont: Grad. downward titrat.
Manage. breakthrough cancer pain in pts
16 and older with maligns. who are
already receiv. and tolerant to opioid ther.
for persist. cancer pain.
C/I: Post-op. pain, opioid non-tol.,
hypersens./intol. to fentanyl, anaphylax.
Opioid. Fentanyl 12.5, 25, 50, 75, 100 mcg/hour. TRANSDERMAL 3-DAY MATRIX PATCHES:
5 x 12.5 μg/hr (2.063 mg/patch); 5 x 25 μg/hr (4.125 mg/patch); 5 x 50 μg/hr
(8.25 mg/patch); 5 x 75 μg/hr (12.375
mg/patch); 5 x 100 μg/hr (16.5 mg/
patch). Initial: Depend. on pts. current
cond., intensity of pain, opioid history.
Dose titrat: Initial dose may be incr.
aft. 3 days with patch replacement;
then titrate every 6 days. See lit.
Breakthrough pain may be treated
with supplement. short-act. analges.
Discont. when necess., gradually.
Manage. chron./intract. pain req. opioid
analges. See lit.
C/I: Opioid intoler., post-op. pain, acute
pain, mild-mod. pain. Concurrent with
Narcotic Anesthetic. Fentanyl 0.05 mg/ml. AMPS: 5,50 x 2 ml,10 ml. The
dosage should be individualized.
Vital signs should be routinely
monitored. See lit.
Surg. anesth. and analges. See lit.
Also epidural route for post-op.
pain, adjunct to regional or general
C/I: Hypersens., as with other opiate.
given epidural., should not be given to
pts. exhibiting: severe hemorrh.
or shock, septicemia, disturb. in blood
morphology. See lit.
Opioid Analgesic. Fentanyl 67, 133, 267, 400, 533, 800 mcg. SUB LING. TABS.:30× 67, 133, 267, 400, 533, 800 mcg. Should be admin. direct.
under the tongue at the deepest part. All pts. must start ther.with a single 133
mcg SG tab. If adequate analgesia is not obtained within 15-30 min. of admin.
of a single tablet, a supplem. (second) 133 mcg tab. may be admin. If tmt. of a
breakthrough pain episode requires more than one dosage unit, an incr. in dose
to the next higher available strength should be consid. Dose escalation should
cont. in a stepwise manner until adequate analgesia is achieved. The dose
strength for the supplement. (2 nd ) tab. should be increased from 133- 267 mcg at
dose of 533 mcg. This is illustrated in the schedule below. No more than two (2)
tabs. should be admin. for a single episode of breakthrough pain during this
titrat. phase. See lit.
Tmt. of breakthrough pain in adult. with cancer who are already receiv. maintenan.
opioid ther. for chron. cancer pain.
C/I: Hypersens. Pts. without mainten. opioid ther. as there is an incr. risk of respirat. depress. Simultan. use of MAO inhib., or within 2 wks. after the cessation of the use of MAO inhib.
Severe respirat. depress. or severe obstruct.lung condit. Tmt. of acute pain other than breakthrough pain.
Opioid Analgesic. Fentanyl 12.5, 25, 50, 75, 100 mcg/hr. TRANSDERMAL PATCHES: 5x12.5µg/hr. (2.1mg/patch), 5x25µg/hr. (4.2mg/patch), 5x50µg/hr. (8.4mg/patch), 5x75µg/hr. (12.6mg/patch), 5x100µg/hr. (16.8mg/patch).
Dosage must be ajust. individ. accord. pt. condit.
Managem. of chron. pain and intractab. pain requir.opioid analgesia. The drug should only be used in pts. who are already receiv. opioid ther., who have demonstrate. opioid tolerance.
C/I: Hypersens. Pts. who did not use an opioid analgesic in the past. Short period pain (e.g., after surgery). Pts. with not chron./ persist. pain. Mild/moder. pain relief. Pts. with sev. breath. problems. Pts. with severe impair. of the CNS funct.(e.g., brain damage). During tmt. with MAO inhib., or within a minim. of 2 wks. of discont. those drugs. Lact. Child. under 2 yrs. of age.