Factor Xa Inhibitor

3 Drugs classified under this drug class

Factor Xa Inhibitor. Rivaroxaban 10 mg.
F.C. TABS: 30. Recommend. dose: 10 mg
orally 1 x dly, initial dose: 6-10 hrs aft. surg. Tmt. durat. acc. to type of surg.
See lit.
Prevent. VTE in adult pts. undergoing
elective hip/knee replace. surg.
C/I: Hypersens. to active substance or
any of the excips., clin. signif. active
bleed., hepat. dis. assoc. with
coagulopathy and clin. relevant bleed.
risk, pregnancy, lact.

Factor Xa Inhibitor. Rivaroxaban 15 mg.
F.C. TABS: 7, 14, 28, 42, 98, 100 x 15 mg. Dosage must be ajust individ. accord. to pt. med. cond.
Prevent. of stroke & system. embolism in
adult pts. with non-valvular AF with one
or more risk factor., such as CHF,
hypertens., age≥75 yrs., diab. mell., prior
stroke or TIA. Tmt. of DVT and PE, and
prevent. of recurrent DVT and PE in
adults. See.lit.
C/I: Hypersens. Active clinical. signific.
bleed. Lesion / cond., if considered to be
a signific. risk for major bleed. (e.g:
current/ recent GI ulcer., presence of
malign. neoplasms at high risk of bleed. ,
recent brain/ spinal inj., recent brain,
spinal or ophthal. surg., recent intracran.
haemorrhage, known/ suspect.
esophagi. varices, arterioven. malfor. ,
vasc. aneurysms/ major intraspinal or
intracereb. vasc. abnormalit. Concom.
tmt. with any other anticoagul. e.g.
unfraction. heparin, low molec. weight
heparins (enoxaparin, dalteparin, etc.),
heparin derivate.(fondaparinux, etc.),
oral anticoag. (warfarin, dabigatran
etexilate, apixaban, etc.) except under
specific circumst. of switch. anticoag.
ther. or when unfraction. heparin is
given at doses necessary to maint. an
open cent. venous/arter. catheter.
Hep. dis. assoc. with coagulopathy and
clinical. relevant bleed. risk include.
cirrhotic pts. with Child Pugh B and C.
Preg., lact.

Factor Xa Inhibitor. Rivaroxaban 20 mg.
F.C. TABS: 7, 14, 28, 98, 100 x 20 mg mg. Dosage must be ajust individ. accord. to pt. med. cond.
Prevent. of stroke & system. embolism in
adult pts. with non-valvular AF with one
or more risk factor., such as CHF,
hypertens., age≥75 yrs., diab. mell., prior
stroke or TIA. Tmt. of DVT and PE, and
prevent. of recurrent DVT and PE in
adults. See.lit.
C/I: Hypersens. Active clinical. signific.
bleed. Lesion / cond., if considered to be
a signific. risk for major bleed. (e.g:
current/ recent GI ulcer., presence of
malign. neoplasms at high risk of bleed. ,
recent brain/ spinal inj., recent brain,
spinal or ophthal. surg., recent intracran.
haemorrhage, known/ suspect.
esophagi. varices, arterioven. malfor. ,
vasc. aneurysms/ major intraspinal or
intracereb. vasc. abnormalit. Concom.
tmt. with any other anticoagul. e.g.
unfraction. heparin, low molec. weight
heparins (enoxaparin, dalteparin, etc.),
heparin derivate.(fondaparinux, etc.),
oral anticoag. (warfarin, dabigatran
etexilate, apixaban, etc.) except under
specific circumst. of switch. anticoag.
ther. or when unfraction. heparin is
given at doses necessary to maint. an
open cent. venous/arter. catheter.
Hep. dis. assoc. with coagulopathy and
clinical. relevant bleed. risk include.
cirrhotic pts. with Child Pugh B and C.
Preg., lact.