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  • Decarboxylase Inhibitor
    4 Drugs classified under this drug class

    All the Drug Class Drugs

    partial basket chart
    Multiple ingredients

    Decarboxylase Inhibitor, Dopamine Precursor. Carbidopa 25 mg, Levodopa 250 mg.
    TABS: 30. Pts. not receiving levodopa:
    Initial dose: 1/2 tab. 3 x dly. incr. by 1/2
    tab. every day or other day until
    optimal response. Opt. resp: 3-6 tabs.
    dly. Max. dose: Not to exceed 8 tabs.
    dly. Pts. receiving levodopa: Adjust
    dosage to provide 25% of previous
    levodopa dosage. Initial dose: 1 tab.
    3-4 x dly.
    Parkinson’s dis.

    partial basket chart
    Multiple ingredients

    Decarboxylase Inhibitor, Dopamine Precursor. Carbidopa (as monohydrate) 5 mg/ml, Levodopa 20 mg/ml.
    INTEST. GEL (cassettes): 7 x 100 ml.
    Total dly dose div. into 3 individ.
    doses: Morn. bolus dose, cont. maint.
    dose & extra bolus doses. Aft. initial
    dose set. fine adjusts. of all 3 settings
    to be carried out over a few wks. If
    medically. justified, admin. dur. night.
    Tmt. advanced levodopa respons.
    Parkinson’s dis. with severe motor flucts.
    and severe hyper-dyskines. when avail.
    combinats. Parkinson products not given
    satisfact. results. +tive test clin. response to
    duodopa admin. via temp. nasoduoden.
    tube reqd. bef. perm. tube insert.
    C/I: Hypersens. to levodopa, carbidopa,
    any excips. Narrow angle glauc., severe
    hepat./ren. insuffic., severe heart fail,
    severe card. arrhythm. Acute stroke,
    non-select MAOIs, select MOA type A
    inhibits. not to be given concom. & to be
    withdrawn at least 2 wks bef. initiat. ther.
    Condit. in which adrenergics are
    contraind., e.g.
    pheochromocyt., hyperthyroid.,
    Cushing’s synd.
    Pts. with suspic. undiagnos. skin lesions
    or a hist. of melanoma.

    Sinemet CR
    partial basket chart
    Multiple ingredients
    Sinemet CR

    Decarboxylase Inhibitor, Dopamine Precursor. Carbidopa 50 mg, Levodopa 200 mg.
    TABS: 30, 60, 100. Pts. not receiving levedopa: Initial: 1 tab 2 x dly at intervals of more than 6 hrs. Pts. receiving levodopa: See lit.
    Idopath. Parkinsons dis., post-encephalit.,
    symptomat. Parkinsons.
    C/I: MAO inhibit. (except low dose
    select. MAO-B inhibit.) not to be admin.
    concom., hypersens.,narrow angle
    glaucoma, skin lesions, history of

    not in the basket chart
    Multiple ingredients

    COMT Inhibitor, Decarboxylase Inhibitor, Dopamine Precursor. Levodopa 50, 75, 100, 125, 150, 200 mg, Carbidopa 12.5, 18.75, 25, 31.25, 37.5, 50 mg, Entacapone 200 mg.
    F.C. TABS: 30. See lit.
    Tmt. Parkinson’s dis., end-of-dose motor
    flucts. not stabiliz. on levodopa/dopa
    decarboxylase (DCC) inhibit. tmt.
    C/I: Hypersens., severe hepat. impair,
    narrow-angle glauc., pheochromocyt.,
    concom. use with MAO-A and MAO-B
    inhibits., prev. history NMS and/or nontraum.
    rhabdomyolys., lact.