All the Drug Class Drugs
Antifibrinolytic. Tranexamic Acid 500 mg / 5ml. AMP. ( sol. for inj.): 5×5 ml.
Adult.: The recomm. standard dosage: 5-10 ml IV, at a rate of 1 ml/min., 2-3 times dly. General Fibrinolysis: 10 ml I.V., 3-4 times dly. Prostatectomy: 5-10 ml by slow I.V. inj., every 8 hrs. (The 1st dose being admin. during the operat.), for the first 3 days follow. surg. When required, oral tmt. with tranexamic acid may be follow. Dental Surg.: Factor VIII or IX concentrates and Tranexamic Acid 10 mg/kg bdy. wt. should be admin. IV immediate. before surg. When required, oral tmt. with tranexamic acid may be followed. Epistaxis: may be applied topical. to the nasal mucosa, either using a spray or by soaking a gauze strip in the sol. and then packing the nasal cavity. Child. : Dosage should be calculated accord. to bdy. wt., 10 mg/kg I.V.
General fibrinolysis. This may occur in prostatic and pancr. carcinoma follow. thoracic surg. and other major operat. proced., in obstetr. complic. such as abruptio placentae and post-partum
hemorrhage, in connect. with thrombolytic ther., and in init. and follow-up tmt. follow. prostatectomy and bladder surg. Prior to, and follow., dental surg. in hemophiliacs. Epistaxis.
C/I: Hypersens. Acute venous/ arter. thrombosis. Fibrinolytic condit. follow. consumpt. coagulopathy except in those with predominant activation of the fibrinolytic systemwith acute severe bleed. Severe renal impair. (risk of accumul.). History of convuls. Intrathecal, intraventr. inject., intracereb. application (risk of cerebr. edema and convuls.).