All the Drug Class Drugs
Anti-Epileptic, Anticonvulsant. Sodium Valproate 333 mg, Valproic Acid 145 mg. P.R. TABS: 30. The Init. dly. dosage is usually 10-15 mg/kg, after which doses are incr. up to the optim. dose.
The mean dosage is 20-30 mg/kg/d. However, if seizures are not brought under control at this dosage it may be incr. and pts. must be closely monitor.
In child., usually 30 mg/kg/d.
In adults, usually 20 to 30 mg/kg/d.
In elderly pts., the dosage should be determ. based on the control of seizur. Tmt. and preven. of manic episodes in the context of bipolar disord.: The recomm. init. dose is 1000 mg/d. The dose should be incr. as fast as possible to the low. dose that brings about the desired clinic. effect. The recomm. mainten. dose for the tmt. of bipolar disord. is between 1000 mg & 2000 mg dly. In except. cases the dose may be incr. to a max. of 3000 mg dly. Dosage should be adjust. individ. See lit.
Epilepsy: Tmt. of general./partial epilep. second. epilep. and mixed forms of epilep.
Bipolar disord.: Tmt. and/or prevent. of acute manic episodes in the context of bipolar disord.
C/I: History of hypersens. to valproate, divalproate, valpromide. Acute hepatit. Chron. hepatit. Hep. porphyria. Person./famil. history of sev. hepatit., in particular drug-related.
Comb. use with mefloquine and St.-John`s-wort. Pts. known to have mitochond. disord. caused by mutations in the nuclear gene encod. mitochond. enzyme polymerase γ (POLG, e.g. Alpers-Huttenlocher Syndr.). Pts. with known urea cycle disord.