Sodium Valproate

3 Drugs classified under this active ingredient

Anticonvulsant. Sodium Valproate 200 mg, 500 mg.
EC Tabs. 40X200 mg, 500 mg
SOL.50 mlX200 mg/ml
SYR. 110 mlX200 mg/5ml
Init: 10-15 mg/kg bw dly, incr. at 5 days or 1 week interv. by 5 mg/kg bw. Elderly:15 mg/kg dly. Adults:20 mg/kg dly. Child and inf.: 25 mg/kg daily. Assess after 2-3 weeks treat. See lit.
Generalized or partial epilepsy, secondary generalized
epilepsy and mixed forms of epilepsy
C/I: Pregnancy unless no suitable alternat.
Women of childbearing potent.
Hypersens. to valproate, valproate semisodium, valpromide or excipients
Accute hepatitis.
Chron. hepatitis.
Pts. or family hist. of sev. hepatitis, especial. drug-related.
Hepat. porphyria.
Pts. with known urea cycle dis.
Pts. with mitoch. dis. caused by mut. in the nuclear gene encoding mitoch. enzyme polymerase gamma (POLG), e.g. Alpers-Huttenlocher Syndr., childr. under 2 years suspect. of having a POLG related dis.
Combinat. with St John’s Wort

Anti-Epileptic, Anticonvulsant. Sodium Valproate 333 mg, Valproic Acid 145 mg.
P.R. TABS: 30. The Init. dly. dosage is usually 10-15 mg/kg, after which doses are incr. up to the optim. dose.
The mean dosage is 20-30 mg/kg/d. However, if seizures are not brought under control at this dosage it may be incr. and pts. must be closely monitor.
In child., usually 30 mg/kg/d.
In adults, usually 20 to 30 mg/kg/d.
In elderly pts., the dosage should be determ. based on the control of seizur. Tmt. and preven. of manic episodes in the context of bipolar disord.: The recomm. init. dose is 1000 mg/d. The dose should be incr. as fast as possible to the low. dose that brings about the desired clinic. effect. The recomm. mainten. dose for the tmt. of bipolar disord. is between 1000 mg & 2000 mg dly. In except. cases the dose may be incr. to a max. of 3000 mg dly. Dosage should be adjust. individ. See lit.
Epilepsy: Tmt. of general./partial epilep. second. epilep. and mixed forms of epilep.
Bipolar disord.: Tmt. and/or prevent. of acute manic episodes in the context of bipolar disord.
C/I: History of hypersens. to valproate, divalproate, valpromide. Acute hepatit. Chron. hepatit. Hep. porphyria. Person./famil. history of sev. hepatit., in particular drug-related.
Comb. use with mefloquine and St.-John`s-wort. Pts. known to have mitochond. disord. caused by mutations in the nuclear gene encod. mitochond. enzyme polymerase γ (POLG, e.g. Alpers-Huttenlocher Syndr.). Pts. with known urea cycle disord.

Anticonvulsant. Sodium Valproate 300 mg / 3 ml.
AMPS (sol. for 1 I.V. inject./ infus.): 5 x 3 ml.
See lit.
Gen. seiz. in form of absence, myoclonic/
tonic-clonic seiz., partial, sec. gen. seiz.
C/I: Hypersens., prev./present liver dis.
See lit.