All the Drug Class Drugs
Anticonvulsant. Sodium Valproate 200 mg, 500 mg. E.C. TABS: 40 x 200 mg, 500 mg.
SOLN: 50 ml x 200 mg/ml.
SYR: 110 ml x 200 mg/5 ml. Initial:
10-15 mg/kg bdy. wt. dly. incr. at 5
days or 1 wk. intervals by 5 mg/kg bdy.
wt. dly. Elderly: 15 mg/kg dly. Adults:
20 mg/kg dly. Child. and Inf: 25 mg/kg
dly. To be assessed aft. 2-3 wks. ther.
All forms of epilepsy (grand, petit, mixed
or partial), porphyria.
Anti-Epileptic, Anticonvulsant. Sodium Valproate 333 mg, Valproic Acid 145 mg. P.R. TABS: 30. The Init. dly. dosage is usually 10-15 mg/kg, after which doses are incr. up to the optim. dose.
The mean dosage is 20-30 mg/kg/d. However, if seizures are not brought under control at this dosage it may be incr. and pts. must be closely monitor.
In child., usually 30 mg/kg/d.
In adults, usually 20 to 30 mg/kg/d.
In elderly pts., the dosage should be determ. based on the control of seizur. Tmt. and preven. of manic episodes in the context of bipolar disord.: The recomm. init. dose is 1000 mg/d. The dose should be incr. as fast as possible to the low. dose that brings about the desired clinic. effect. The recomm. mainten. dose for the tmt. of bipolar disord. is between 1000 mg & 2000 mg dly. In except. cases the dose may be incr. to a max. of 3000 mg dly. Dosage should be adjust. individ. See lit.
Epilepsy: Tmt. of general./partial epilep. second. epilep. and mixed forms of epilep.
Bipolar disord.: Tmt. and/or prevent. of acute manic episodes in the context of bipolar disord.
C/I: History of hypersens. to valproate, divalproate, valpromide. Acute hepatit. Chron. hepatit. Hep. porphyria. Person./famil. history of sev. hepatit., in particular drug-related.
Comb. use with mefloquine and St.-John`s-wort. Pts. known to have mitochond. disord. caused by mutations in the nuclear gene encod. mitochond. enzyme polymerase γ (POLG, e.g. Alpers-Huttenlocher Syndr.). Pts. with known urea cycle disord.
Anticonvulsant. Levetiracetam 250, 500, 1000 mg. F.C. TABS: 60 x 250 mg, 500 mg, 1,000
child & adolesc. 12-17 yrs, wt. 50 kg or
more: Initial: 500 mg 2 x dly on 1st day
of tmt. Depend. on clin. response/
tolerabil. can incr. dly dose up to 1,500
mg 2 x dly. Dose changes can be made
in 500 mg increments/decrements 2 x
dly every 2-4 wks. Child 4-17 yrs wt.
less than 50 kg: Initial 10 mg/kg body
wt 2 x dly. Depend. on clin./tolerabil,.
incr. up to 30 mg/kg bdy wt. 2 x dly
every 2 wks. Dose changes not to
exceed increments/decrements of 10
mg/kg bdy wt. 2 x dly every 2 wks. Use
lowest effect. dose. Inf./child under 4
yrs: Not recommend. Elderly: Adjust if
renal funct. compromised. Renal
impair: Adjust individ. accord. to ren.
funct. Severe hepat. impair: Creatinine
clear. may underest. ren. insuffic; 50%
reduct. dly maint. dose is recommend.
at creatinine clear. of <70 ml/min.
Adjunct. ther. tmt partial onset seiz. with/
without second. generaliz. pts with