All the biological system drugs
Fibrate. Bezafibrate 400 mg. SR Tab. 30 X 400 mg
One tablet, to be swallowed whole with suffic. fluid after a meal either in the
morning or at night.
Adjunct to diet and other non- pharmacological
tmt. (e.g. exercise, weight reduct.) for
the tmt. of sev. hypertriglyceridaemia
C/I: Hypersens. – Signif. hepatic dis. (other than fatty infiltr. of the liver assoc. with raised triglyceride values).
- Gall-bladder dis. with or without cholelithiasis.
- Pts. with nephrotic syndr. and sev. renal fail. (serum creatinine > 135μmol/l; creatinine clear.<60ml/min) and pts. undergoing dialysis.
- Combin. ther. (concom. use) of bezafibrate with HMG CoA reductase inhibit. (statins) in pts. with predisposing factors for myopathy.
- Known photoallergic or phototoxic reactions to fibrates.
Myosin inhibitor. mavacamten 2.5 mg, 5 mg, 10 mg, 15 mg. 14/28 X 2.5mg, 5mg, 10mg or 15mg
Recommend. starting dose is 5 mg orally once/d without regard to food; allowable subseq. doses with titration are 2.5 mg, 5 mg, 10 mg, or 15 mg orally once/d. The max. recommend. dose is 15 mg /d. See lit.
Tmt. of adults with symptomatic
NYHA class II-III obstructive hypertrophic cardiomyopathy (HCM)
to improve functional capacity and sympt.
C/I:Hypersens. /Moder. to strong CYP2C19 inhibit. or strong CYP3A4 inhibit.
/Moder. to strong CYP2C19 inducers or moder. to strong CYP3A4 inducers.
Bradykinin β-2 Receptor antagonist. Icatibant (as acetate) 30 mg / 3 ml. PREFILL. SYR. (sol. for inject.): 1 ×3 ml.
1 x 30 mg S.C. inj. in abd. area given
slowly. 1 inj. should suffic. In case of
recur. in adults can admin. 2nd inject aft. 6 hrs. or a 3rd
inj. aft. another 6 hrs. max. 3 inj. in 24 hrs. See lit.
Sympt. tmt. acute attacks hereditary
angioedema (HAE) in adults, adolesc. & child. aged 2 yrs and old. with
C1-esterase-inhib. defic.
C/I: Hypersens.
Bradykinin B2 Receptor Antagonist. Icatibant (as acetate) 30 mg / 3 ml. SYR. (Sol. for S.C. inj.).: 1. One S.C. inj. of Icatibant (3 ml/30 mg), as soon as signs of attack are detected (e.g. swelling of the skin, especially in the area of the face and neck, or increas. abdom. pain).
If the condition is not improved in 6 hrs., another 3 ml dose may be admin.
If there is still no improv., a 3rd dose may be admin. after another 6 hrs.
No more than 3 doses in 24 hrs. and no more than 8 inj. of icatibant in one month. Child.& adolesc. 2-17 yrs. of age: 1 ml up to a max. of 3 ml, inject. S.C. accord. to bdy. wt. (one syr. contains 3 ml), as soon as signs of angioedema attack develop (e.g. incr.swell. of the skin, especially in the area of the face and neck, or increas. abd. pain). See lit.
Symptomat. tmt .of acute attacks of hereditary angioedima (HAE) in adult., adolesc. & child. aged 2 yrs. and older, with C1-esterase-inhib. defic.
C/I: Hypersens.
