All the Active Ingredient Drugs
Antifungal. Voriconazole 50 mg, 200 mg, 40 mg/ml. F.C. TABS: 14, 28 x 50 mg, 200 mg.
VIALS: 1 x 200 mg/vial.
PWDR. FOR ORAL Sol. (orange flav.): 40 mg/ml. Adults (40 kg and above): Load. dose (first 24 hrs.): 400 mg every 12 hrs. Maint. (aft. first 24 hrs.): 200 mg 2 x dly.
Adults (less than 40 kg): Load. dose (first 24 hrs.): 200 mg every 12 hrs. Maint. (aft. first 24 hrs.): 100 mg 2 x dly.
Child aged 2 to < 12 yrs: No oral/I.V. load. dose recommend. Maint: I.V: 7 mg/kg 2 x dly; Ped. pts. unable to tol. 7 mg/kg 2 x dly may reduce to 4 mg/kg 2 x dly. Oral: 200 mg 2 x dly. See lit.
Tmt. of candidemia in non-neutropen. pts.
Tmt. of fluconazole resist. serious invas.
Candida infec. (includ. C. krusei).
Tmt. of serious fung. infec. caused by Scedosporium spp. & Fusarium spp. Should be admin. primary to immunocomprom. pts. with progress., possibly life-threaten. infec.
Prophyl. of invas. fungal infec. in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipient.
C/I: Hypersens./ Coadmin. with med. prod. that are highly dependent on CYP3A4 for metabolism, and for which elevated plasma concentr. are associated with serious and/or life-threatening reactions :• Terfenadine, Astemizole • Cisapride
• Pimozide, Lurasidone • Quinidine • Ivabradine
• Ergot alkaloids (e.g., ergotamine, dihydroergotamine) • Sirolimus
• Naloxegol • Tolvaptan • Finerenone • Venetoclax: contraindic. at initiation and during venetoclax dose titrat. phase.
Coadmin. with med. prod. that induce CYP3A4 and signif. reduce voriconazole plasma concentr.: rifabutin, rifampicin, carbamazepine, long-acting barbiturates e.g., phenobarbital and St John’s Wort. • Efavirenz: coadmin. of standard doses of voriconazole with efavirenz doses of 400 mg once/d or higher.• Ritonavir: coadmin. with high- dose ritonavir (400 mg and above twice/d). For info. on coadmin. with lower doses of ritonavir see lit.
Antifungal. Voriconazole 200 mg. FC Tabs 14/28/30X200 mg Dosage depend. on ptt. weight and type of infect. Refer to the license holder for further details
Invasive aspergillosis, Fluconazole-resist. serious invas. Candida infections (incl. C. krusei). Ser. fungal infect. caused by Scedosporium spp. and Fusarium spp.
To be admin. primarily to immunocomprom. pts with progress possibly life-threatening infect. Tmt of candidemia in non-neutropenic pts. Prophylaxis of invas. fungal infect. in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients.
C/I: Hypersens. Coadmin. with med. prod. that are highly dependent on CYP3A4 for metabolism, and for which elevated plasma concentr. are associated with serious and/or life-threatening reactions: terfenadine, astemizole, cisapride, pimozide, quinidine, ivabradine, rifabutin, rifampicin, carbamazepine, phenobarbital, ergot deriv., sirolimus, efavirenz (at dosage of 400 mg and more given once daily), ritonavir (at dosage of 400 mg and more each time , given twice daily), St. john's wort, naloxegol, tolvaptan, lurasidone, finerenone, venetoclax.
Antifungal. Voriconazole 200 mg. TABS:14 ,28. Pts. less than 40
kg-100mg ×2/day (every 12 hrs.
Pts. 40 kg and above – 200mg×2/day
(every 12 hrs.).
Tmt. of: invas. aspergillosis, Candidemia
in non-neutropenic pts., Fluconazole
resist. serious invas. Candida infec.
(include. C. krusei), serious fung. infec.
caused by Scedosporium spp. and
Fusarium spp. Voriconazole should be
adminis. prim. to immunocomprom. pts.
with progressive, possibly life-threaten.
infec.
C/I: Known hypersens. to vinorelbine or
any other constit. Concom. use with:
Terfenadine, Estemizole, Cisapride,
Pimozide, Quinidine, Rifabutin,
Rifampicin, Carbamazepine,
Phenobarbital, Mephobarbital, Ergot
derivate. (like Ergotamine,
Dihydroergotamine), Sirolimus,
Efavirenz, Ritonavir, St. John’s Wort.
Pts. with intoler. to galactose or unable
to digest lactose or galactose, since the
tabs. contain lactose. Child. under 2 yrs.
of age.
