All the Active Ingredient Drugs
Biguanide, DPP-4 Inhibitor. Vildagliptin 50 mg, Metformin Hydrochloride 500, 850, 1000 mg. F.C. TABS: 60 x Vildagliptin 50 mg/
Metformin 500 mg; 60 x
Vildagliptin 50 mg/Metformin 850 mg;
Vildagliptin 50 mg/Metformin 1,000 mg.
Based on the pt. current dose of
Metformin, tmt. may be init. at either
50 mg /500 mg or 50 mg/850 mg or 50
mg/1000 mg tab. strength BID, one
tab. in the morning and evening. Pts
already receiving metformin +
vildagliptin from separate tabs: switch
to the equivalent combined tab. Daily
doses >100 mg of vildagliptin are not
recommend. See lit.
Tmt. type 2 diabetes mellitus in adult pts.
insuffic. controlled with max. tolerat.
dose Metformin alone or already treat.
with vildaliptin and Metformin as
separate tabs. In comb. with a
sulfonylurea as an adjunct to diet and
exercise in adult pts. inadeq. controlled
with metformin and a sulfonylurea. In
triple comb. ther. with insulin as an
adjunct to diet and exercise to improve
glycaemic control in adult pts.when
insulin at a stable dose and Metformin
alone do not provide adeq. glycaemic
control.
C/I: Hypersens., Diab. ketoacid., diabet.
pre-coma. Ren. fail. ,ren,dysfunc, (CrCl<
60 ml/min) dehydr., sev. infec., shock.
Intravasc. admin. of iod. contrast ag. Acute/ chron. dis. which may cause
tissue hypox., (e.g: Card. fail.). Resp. fail.,
recent MI, Hep. impair. Acute alcohol
intox., alcoholism. Lact.
DPP-4 Inhibitor. Vildagliptin 50 mg. TABS: 7, 14, 28, 56.
Dosage must be indivi. ajust. for each pt.
Monotherpy: 50 mg x1 dly in the
morning or 50 mg x 2 dly (morn.,even.).
In combin. with other antidiabetics:
see lit. Max 100 mg dly, with/out food.
As adjunct to diet, exercise in type 2
diabetes mellitus: As monother. if diet,
exercise insuffic., or in combinat. with
metformin or sulfonylurea if tmt. with
these offers insuffic. control blood
glucose. As triple ther. in combinat. with
a sulphonylurea and metformin when
diet, exercise plus dual therapy do not
provide adequate glycaemic control.
Comb. use with insulin (with/ without
metformin) when diet, exercise plus a
stable dose of insulin do not provide
adequate glycaemic control. As an
adjunct to diet and exercise in pts. with
type 2 diabetes mellitus.In comb. with a
thiazolidinedione, in pts. with insuffic.
glycaemic control and for whom the use
of a thiazolidinedione is appropriate.
C/I: Hypesens.
Biguanide, DPP-4 Inhibitor. Vildagliptin 50 mg, Metformin Hydrochloride 850 mg, 1000 mg. FC tab 28/30/56/60
Dose to be adjusted indiv. Max daily dose: 100 mg vildagliptin. See lit.
Tmt.of type 2 diabetes mellitus:- for adult pts. who are unable to achieve sufficient glycaemic ctrol. at their max. toler. dose of oral metformin alone or who are already treated with vildagliptin and metformin as separate tablets.- in combin. with a sulphonylurea (i.e. triple combin. ther.) as an adjunct to diet and exercise in adult pts. inadequat. controlled with metformin and a sulphonylurea.- indic. in triple combin. ther. with insulin as an adjunct to diet and exercise to improve glycaemic ctrol. in adult pts. when insulin at a stable dose and metformin alone do not provide adeq. glycaemic ctrol.
C/I: Hypersens./Any type of acute metabolic acidosis /Diabetic pre-coma/
Sev. renal fail. (GFR < 30 ml/min) /
Acute condit. with the potential to alter renal function:
dehydration, sev. infect., shock, IV admin. of iodinated contrast agents./
Acute or chron. dis. which may cause tissue hypoxia, such as:
cardiac or respiratory fail., recent myocardial infarct., shock/
Hepatic impairm./Acute alcohol intox., alcoholism/ Breast-feeding.
