All the Active Ingredient Drugs
Anti-Epileptic, Anticonvulsant. Sodium Valproate 333 mg, Valproic Acid 145 mg. P.R. TABS: 30. The Init. dly. dosage is usually 10-15 mg/kg, after which doses are incr. up to the optim. dose.
The mean dosage is 20-30 mg/kg/d. However, if seizures are not brought under control at this dosage it may be incr. and pts. must be closely monitor.
In child., usually 30 mg/kg/d.
In adults, usually 20 to 30 mg/kg/d.
In elderly pts., the dosage should be determ. based on the control of seizur. Tmt. and preven. of manic episodes in the context of bipolar disord.: The recomm. init. dose is 1000 mg/d. The dose should be incr. as fast as possible to the low. dose that brings about the desired clinic. effect. The recomm. mainten. dose for the tmt. of bipolar disord. is between 1000 mg & 2000 mg dly. In except. cases the dose may be incr. to a max. of 3000 mg dly. Dosage should be adjust. individ. See lit.
Epilepsy: Tmt. of general./partial epilep. second. epilep. and mixed forms of epilep.
Bipolar disord.: Tmt. and/or prevent. of acute manic episodes in the context of bipolar disord.
C/I:hypersens./ a personal or family hist. of liver dis. or manifest sev. hep.or pancreatic dysfunction / disord. of hep. function with a fatal outcome during valproic acid tmt in siblings / hepatic porphyria/ blood coag. disord./
mitoch. disord. caused by mutations in the nuclear gene encoding the mitoch. enzyme polymerase γ (POLG), e.g. Alpers-Huttenlocher Syndr., and in children < 2 years who are suspected of having a POLG-related disord. /known urea cycle disord./
in uncorrected syst. primary carnitine deficiency.
Treatment of epilepsy
in pregn. unless there is no suitable altern. tmt. / in women of childbearing pot., unless the conditions of the Pregnancy Prevention Program (PPP) are fulfilled
Treatment of bipolar disorder
in pregn./ in women of childbearing pot., unless conditions of the PPP are fulfilled.
