All the Active Ingredient Drugs
Glucosylceramide Synthase Inhibitor. Miglustat 100 mg. CAPS: 84. Gaucher dis. Adults: Initial:
100 mg 3 x dly. Tempor. dose reduct. to
100 mg once/ twice a d. may be neces.
in some pts. because of diarrhoea.
Can be taken with/ without food.
Ped. popul. : The efficacy of Miglustat
in child. & adolesc. aged 0-17 yrs. with
type 1 Gaucher dis. has not been
Niemann-Pick type C dis.: Adult. –
Ped. popul. (pts. 12 yrs. and above)
Dosing in pts. under the age of 12 yrs.
should be adjust. on the basis of bdy.
surface. ar- See lit.
Oral tmt. of mild- moder. type 1 Gaucher
dis. Miglustat may be used only in the
tmt. of pts. for whom enzyme replac. ther.
Miglustat is indic. for the tmt. of progres.
neurological manifest. in adult pts. and
paed. pts. with Niemann-Pick type C dis.