All the Active Ingredient Drugs
Retinoid. Isotretinoin 5, 10, 20, 30, 40 mg. SOFT CAPS: 30, 60. See lit.
Severe recalcitrant nodular acne.
C/I: Pregn., lact., hepat. and renal
insuffic., hypervit. A, excess. elevated
blood lipid, hypersens. Not to be taken
with tetracycl.
Retinoid. Isotretinoin 5 mg, 10 mg, 20 mg, 40 mg. Soft gel caps 30 X 5/10/20/40 mg
Capsules to be taken with food 1 once or twice /d. Adults and adolescents>12:Start at a dose of 0.5 mg/kg dly. Adjust dose indiv. For most pts., from 0.5-1.0 mg/kg/d. Long-term remission and relapse rates are more closely rel. to total dose admin. than to either duration of tmt. or dly. dose. No substant. addit. benefit to be expected beyond a cumulative dose of 120-150 mg/kg. Duration of tmt. will depend on dly. dose. A tmt. course of 16-24 weeks is normally suffic. to achieve remission. In the majority of pts., complete clearing of acne is obtained with a sgle. course. In the event of a definite relapse at least 8 weeks after discontinuat., a further course may be considered using same dly. and cumulative dose.
For the tmt. of sev. cystic acne that does not respond to other tmt.
C/I: Hypersens.
Pregn. or breastf.
Women of childbearing potent. unless all of the condit. of the Pregn. Prevent. Progr.are met. Teratogenic
• hepatic insuffic.
• excess. elev. blood lipid values
• hypervitaminosis A
• concomitant treatment with tetracyclines
