All the Active Ingredient Drugs
Antimetabolite (purine analog). Cladribine 10 mg / 5 ml. VIALS: 1,5. HCL: S.C: 0.14 mg/kg bdy wt/
day (5.6 mg/m2/day) for 5 consec. days.
I.V. (Contin. infus.): Single course for 7
consec. days: 0.09 mg/kg/day (3.6 mg/
m2/day). CLL: S.C: 0.1 mg/kg bdy wt/
day for 5 consec. days (4.0 mg/ m2/
day). I.V: 2 hrs. on days 1-5 of 28 day
cycle at dose of 0.10 mg/kg/day (4.0
mg/m2 /day). Determine pt. response
every 2 cycles of tmt. In respond. pts.
(lymphocyt. reduct. of 50% or more)
repeat for 2 cycles. In non-respond.
pts. discont. aft. 2 cycles.
Hairy cell leuk. (HCL), chronic lymphocyt.
leuk.(CLL), second line tmt. low grade
Non-Hodgkins lymphoma (NHL).
Immunosuppressant. Cladribine 10 mg. Tab: 1/4/6X 10 mg: 3.5 mg/kg bw over 2 years, admin. as 1 tmt. course of 1.75 mg/kg per year. Tmt. course consists of 2 tmt. weeks, one at the beginn. of the first month and one at the beginn. of the sec. month of the respect. tmt. year. See prescr. info.
Tmt. of adlt. pts. with high. act. relaps. multiple sclerosis (MS) as by clinical or imaging features
C/I: Hypersens.
HIV.
Act. chron. infect. (tuberculosis or hepatitis).
Init. of this tmt. in immunocomprom. pts, incl. pts. on
immunosuppr. or myelosuppr. ther. (See prescr. info).
Act. malign.
Mod. or sev. renal impair. (creat. clear. <60 mL/min) (See prescr. info).
Pregn. and breast-feed.