Digoxin-Zori

/ Teva

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Congestional heart failure, atrial flutter, paroxysmal atrial tachycardia.

Known hypersensitivity. Ventricular fibrillation.
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Many of the arrhythmias for which digoxin is indicated closely resemble those reflecting digoxin intoxication. Anorexia, nausea, vomiting and arrhythmias may accompany heart failure or may be indicative of digoxin intoxication. Electrical conversion of arrhythmias may require reduction of dosage of digoxin, to avoid induction of ventricular arrhythmias. However, the consequences of a rapid increase in ventricular response to atrial fibrillation should be considered if digoxin is withheld 1-2 days prior to cardioversion. Patients still experiencing effects from previous digitalis preparations, and in the presence of multiple ventricular extrasystoles or heart block. Patients with incomplete atrioventricular (AV) block, especially those subject to Stokes-Adams attacks, may develop advanced or complete heart block if digoxin is administered. Patients with acute myocardial infarction, severe pulmonary disease, rheumatic carditis, or advanced heart failure. If a therapeutic trial does not result in improvement, the drug should be discontinued. Patients with chronic constrictive pericarditis, patients with Wolff-Parkinson-White syndrome. The presence of acute glomerulonephritis accompanied by CHF requires extreme care in digitalization. Pregnancy and lactation, pediatrics, elderly, hypokalemia. Calcium i.v. should not be administered to patients receiving digoxin. Hypomagnesemia. The plasma half-life of digoxin is inversely related to thyroid status. Atrial arrhythmias associated with hypermetabolic states are particularly resistant to digoxin treatment. Patients with renal impairment.
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Anorexia, nausea, vomiting and diarrhea are the most common early symptoms of overdose. Uncontrolled heart failure may also produce such symptoms. Visual disturbances, headache, weakness, apathy, drowsiness, mental depression, confusion, disorientation, seizures, EEG abnormalities and delirium, muscular weakness, arrhythmias.
See prescribing information for full details.

See prescribing information for full details.